North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 111 clinical trials
A Study to Evaluate the Safety and Efficacy of PF-06650833 PF-06700841 and PF 06826647 in Adults With Hidradenitis Suppurativa

This is a study with 3 kinase inhibitors (PF 06650833, PF 06700841 and PF 06826647) in participants with moderate to severe HS. The study will have a maximum duration of approximately 26 weeks. This includes an up to 6-week Screening Period, a 16 week Dosing Period and a 4 week …

Westmead Hospital
 (7.7 away) Contact site
  • 25 Nov, 2020
  • +72 other locations
Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis

The objective of this trial is to assess the efficacy and safety of CNM-Au8 as a remyelinating treatment for vision-impairing MS lesions in participants who have chronic vision impairment as a result of Relapsing Remitting Multiple Sclerosis. The primary endpoint is the improvement in low contrast vision as measured by …

disease or disorder
relapsing multiple sclerosis
diabetic retinopathy
Royal North Shore Hospital
 (4.8 away) Contact site
  • 11 Nov, 2020
  • +8 other locations
Therapeutic Nanocatalysis to Slow Disease Progression of Amyotrophic Lateral Sclerosis (ALS)

The objective of this trial is to assess the efficacy, safety, and PK/PD effects of CNM-Au8 as a disease-modifying agent for the treatment of ALS by utilizing electrophysiological measures to detect preservation of motor neuron function. The primary endpoint is the mean change in the average difference between active treatment …

primary lateral sclerosis
University of Sydney Brain and Mind Centre
 (7.3 away) Contact site
  • 11 Nov, 2020
  • +1 other locations
Study Evaluating Cemiplimab Alone and Combined With RP1 in Treating Advanced Squamous Skin Cancer

To estimate the clinical benefit of cemiplimab monotherapy versus cemiplimab in combination with RP1 for patients with locally advanced or metastatic CSCC, as assessed by overall response rate (ORR) according to central review.

skin cancer
Chris O'Brien Lifehouse
 (7.3 away) Contact site
  • 26 Oct, 2020
  • +14 other locations
Treatment Continuation Study for Patients With ALS/MND Who Completed Study CMD-2019-001

Provides up to six months treatment with CuATSM for subjects who have successfully completed study CMD-2019-001

Macquarie University
 (0.8 away) Contact site
  • 22 Mar, 2020
  • 1 location
Efficacy Safety and Tolerability of NP-120 on Idiopathic Pulmonary Fibrosis and Its Associated Cough

NP-120 (Ifenprodil) has been shown to mediate anti-inflammatory responses and reduce pulmonary fibrosis in a murine model of Idiopathic Pulmonary Fibrosis (IPF). In addition, NP-120 significantly reduced both cough frequency and onset in a guinea pig tussive model. The purpose of this proof-of-concept trial is to determine the efficacy of …

pulmonary function test
carbon monoxide
Concord Repatriation General Hospital
 (4.4 away) Contact site
  • 15 Jul, 2020
  • +4 other locations
Exercise as Concussion Therapy Trial- 2

This study is a Phase 2, open-label study of a therapeutic intervention (graded exercise)compared to a reference therapy (passive stretching) in patients who have sustained mTBI. Subjects will be randomly assigned with a ratio of 1:1 to complete either graded exercise or passive stretching using a parallel-group design. The effects …

Royal Prince Alfred Hospital
 (7.3 away) Contact site
  • 15 Oct, 2020
  • +2 other locations
Immunotherapy Adjuvant Trial in Patients With Stage I-III Merkel Cell Carcinoma

The I-MAT trial is a phase II randomised and placebo-controlled trial for patients with stage I-III Merkel cell carcinoma (MCC) to explore efficacy and tolerability of avelumab as adjuvant immunotherapy.

renal function
positron emission tomography
Melanoma Institute Australia
 (5.0 away) Contact site
  • 26 Nov, 2020
  • +12 other locations
Intralesional Sclerosant for in Transit and Cutaneous Melanoma Metastases

There is currently an urgent need for low cost and well tolerated intralesional agents for the management of in transit and cutaneous melanoma metastases that are unsuitable for, or resistant to, other therapies. This pilot study will determine whether intralesional injections of the sclerosant polidocanol into intransit and cutaneous melanoma …

Royal Prince Alfred Hospital
 (7.3 away) Contact site
  • 27 May, 2020
  • 1 location
A Phase II Study to Determine Pembrolizumab as Frontline Treatment of Patients With Hodgkin Lymphoma

The purpose of this study is to test how safe and effective the research study drug, pembrolizumab is as a treatment for patients with Hodgkin lymphoma who have not previously been treated for this disease and are unsuitable for standard treatment (adriamycin, bleomycin, vinblastine, dacarbazine ABVD).

Concord Hospital
 (3.5 away) Contact site
  • 24 Sep, 2020
  • +5 other locations