North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 127 clinical trials
A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma

In this study, patients with BCC will be given neoadjuvant treatment with a drug called sonidegib. Sonidegib is a daily tablet usually given for BCC that cannot be removed by surgery or that has spread through the body. The study aims to see if sonidegib given for 12 weeks will …

carcinoma
imiquimod
scarring
adjuvant therapy
sonidegib
Melanoma Institute Australia
 (5.9 away) Contact site
  • 5 views
  • 07 Mar, 2021
  • 1 location
Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis

The objective of this trial is to assess the efficacy and safety of CNM-Au8 as a remyelinating treatment for vision-impairing MS lesions in participants who have chronic vision impairment as a result of Relapsing-Remitting Multiple Sclerosis. The primary endpoint is to assess the efficacy and safety of CNM-Au8 as a …

relapsing multiple sclerosis
deficit
diabetic retinopathy
disease or disorder
Royal North Shore Hospital
 (4.8 away) Contact site
  • 32 views
  • 09 May, 2021
  • +16 other locations
A Study to Evaluate the Safety and Efficacy of PF-06650833 PF-06700841 and PF 06826647 in Adults With Hidradenitis Suppurativa

This is a study with 3 kinase inhibitors (PF 06650833, PF 06700841 and PF 06826647) in participants with moderate to severe HS. The study will have a maximum duration of approximately 26 weeks. This includes an up to 6-week Screening Period, a 16 week Dosing Period and a 4 week …

hidradenitis
Holdsworth House Medical Practice
 (7.3 away) Contact site
  • 717 views
  • 25 Jul, 2021
  • +87 other locations
Therapeutic Nanocatalysis to Slow Disease Progression of Amyotrophic Lateral Sclerosis (ALS)

The objective of this trial is to assess the efficacy, safety, and PK/PD effects of CNM-Au8 as a disease-modifying agent for the treatment of ALS by utilizing electrophysiological measures to detect preservation of motor neuron function. The primary endpoint is the mean change in the average difference between active treatment …

primary lateral sclerosis
riluzole
University of Sydney Brain and Mind Centre
 (7.3 away) Contact site
  • 17 views
  • 30 Jul, 2021
  • +1 other locations
A Study to Evaluate the Effectiveness and Safety of IONIS-FB-LRx an Antisense Inhibitor of Complement Factor B in Adult Participants With Primary IgA Nephropathy

The purpose of this study is to evaluate the effectiveness and safety of IONIS-FB-LRx, an antisense inhibitor of complement factor B messenger ribonucleic acid (CFB mRNA), and to evaluate the effect of IONIS-FB-LRx on plasma factor B (FB) levels and serum AH50, CH50 activity in participants with primary immunoglobulin A …

IONIS Investigative Site
 (4.8 away) Contact site
  • 14 views
  • 23 Jun, 2021
  • +5 other locations
Efficacy Safety and Tolerability of NP-120 on Idiopathic Pulmonary Fibrosis and Its Associated Cough

NP-120 (Ifenprodil) has been shown to mediate anti-inflammatory responses and reduce pulmonary fibrosis in a murine model of Idiopathic Pulmonary Fibrosis (IPF). In addition, NP-120 significantly reduced both cough frequency and onset in a guinea pig tussive model. The purpose of this proof-of-concept trial is to determine the efficacy of …

nintedanib
diffusion capacity of the lung for carbon monoxide
forced vital capacity
carbon monoxide
pulmonary function test
Concord Repatriation General Hospital
 (4.4 away) Contact site
  • 25 views
  • 22 Apr, 2021
  • +5 other locations
Intralesional Sclerosant for in Transit and Cutaneous Melanoma Metastases

There is currently an urgent need for low cost and well tolerated intralesional agents for the management of in transit and cutaneous melanoma metastases that are unsuitable for, or resistant to, other therapies. This pilot study will determine whether intralesional injections of the sclerosant polidocanol into intransit and cutaneous melanoma …

melanoma skin
metastasis
malignant melanoma of skin
Royal Prince Alfred Hospital
 (7.3 away) Contact site
  • 0 views
  • 23 Jun, 2021
  • 1 location
A Study of KER-050 to Treat Anemia Due to Very Low Low or Intermediate Risk Myelodysplastic Syndromes

The purpose of this study is to evaluate the effects of KER-050 on anemia in patients with very low, low or intermediate risk MDS.

anemia
bone marrow procedure
blood transfusion
Keros Investigative Site
 (7.7 away) Contact site
  • 32 views
  • 26 Jan, 2021
  • +11 other locations
Tricaprilin Phase 2 Pilot Study in Migraine

This is a randomised, double-blind, placebo-controlled, parallel-group, multi-centre study of tricaprilin as AC-SD-03 compared with placebo for the reduction of migraine in participants with frequent migraine.

headache
Holdsworth House
 (7.3 away) Contact site
  • 0 views
  • 16 Jun, 2021
  • +10 other locations
A Phase II Study of Neoadjuvant Pembrolizumab & Lenvatinib for Resectable Stage III Melanoma

In many cancers, early stage diagnosis and early treatment offers the best chance of a prolonged recurrence free- and overall survival. In stage III/IV resectable melanoma, an opportunity exists to improve outcomes with the addition of neoadjuvant and adjuvant systemic therapy as an adjunct to surgery. Neoadjuvant clinical trials for …

Melanoma Institute Australia
 (5.0 away) Contact site
  • 0 views
  • 20 Jun, 2021
  • 1 location