North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 45 clinical trials
Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)

The purpose of this study is to assess the efficacy and safety of the combination of pembrolizumab (MK-3475) and enzalutamide in the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) who have not received chemotherapy for mCRPC, are abiraterone-nave, or are intolerant to or progressed on abiraterone acetate. There …

diphosphonates
enzalutamide
androgen suppression
bisphosphonate
cancer
Macquarie University ( Site 0151)
 (1.3 away) Contact site
  • 487 views
  • 02 Dec, 2020
  • +220 other locations
Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate

The purpose of this study is to determine the effectiveness of darolutamide as part of adjuvant androgen deprivation therapy (ADT) with a luteinising hormone releasing hormone analogue (LHRHA) in men having radiation therapy for localised prostate cancer at very high risk of recurrence.

external beam radiotherapy
adenocarcinoma
immunological adjuvant
gonadotropin
androgen suppression
Northern Cancer Institute
 (5.0 away) Contact site
  • 62 views
  • 07 Oct, 2020
  • +30 other locations
INTense ExeRcise for surviVAL Among Men With Metastatic Prostate Cancer (INTERVAL - GAP4)

To determine if supervised high intensity aerobic and resistance training increases overall survival compared to self-directed exercise in patients with metastatic prostate cancer.

bone metastases
enzalutamide
ct scan
serum testosterone
metastasis
Chris O'Brien Lifehouse
 (7.3 away) Contact site
  • 1838 views
  • 02 Sep, 2020
  • +27 other locations
A Study of Adding Apalutamide to Radiotherapy and LHRH Agonist in High-Risk Patients With Prostate-Specific Membrane Antigen-Positron Emission Tomography (PSMA-PET) Positive Hormone-Sensitive Prostate Cancer Participants

The main purpose of this study is to determine if the addition of apalutamide to radiotherapy (RT) plus luteinizing hormone-releasing hormone agonist (LHRHa) delays metastatic progression as assessed by prostate specific membrane antigen-positron emission tomography (PSMA-PET) or death compared with RT plus LHRHa alone.

Macquarie University Hospital
 (1.3 away) Contact site
  • 0 views
  • 30 Nov, 2020
  • +63 other locations
Radiation Hypofractionation Via Extended Versus Accelerated Therapy (HEAT) For Prostate Cancer

Accelerated Hypofractionation Radiotherapy for prostate cancer of 36.25 Gy delivered in 5 fractions will not be inferior to the standard treatment of 70.2 Gy given in 26 fractions with respect to two-year failure defined as a positive biopsy two years post treatment completion or earlier evidence of biochemical or clinical …

adenocarcinoma
prostate specific antigen
androgen suppression
hypofractionated radiation therapy
prostatectomy
Northern Sydney Local Health District - Royal North Shore Hospital
 (4.8 away) Contact site
  • 26 views
  • 28 Jun, 2020
  • +3 other locations
Safety and Feasibility of the Mercury Expander System

To demonstrate the safety and feasibility of the Mercury Expander system and procedure to treat patients with lower urinary tract symptoms (LUTS) secondary to urinary outflow obstruction from benign prostatic hyperplasia.

rectal ultrasound
transrectal ultrasound
cystoscopy
lower urinary tract symptoms
benign prostatic hypertrophy
Australian Clinical Trials Pty Ltd
 (5.1 away) Contact site
  • 20 views
  • 23 Feb, 2020
  • +2 other locations
A Trial of 177Lu-PSMA617 Theranostic Versus Cabazitaxel in Progressive Metastatic Castration Resistant Prostate Cancer

This open label, randomised, stratified, 2-arm, multicentre, phase 2 trial aims to determine the activity and safety of Lu-PSMA vs cabazitaxel in men with progressive metastatic castration resistant prostate cancer

gonadotropin
neutrophil count
gnrh
cancer
metastasis
Royal North Shore Hospital
 (5.0 away) Contact site
  • 443 views
  • 08 Nov, 2020
  • +3 other locations
A Gene Transfer Study for Hemophilia A

This clinical research study is being conducted by Spark Therapeutics, Inc. to determine the safety and efficacy of the factor VIII gene transfer treatment with SPK-8011 in individuals with hemophilia A.

cryoprecipitate
antihemophilic factor
Royal Prince Alfred Hosptial
 (7.5 away) Contact site
  • 790 views
  • 05 Nov, 2020
  • +10 other locations
Clinical Investigation of GT UrologIcal LLC's Artificial Urinary Sphincter (RELIEF II)

The purpose of this investigation is to demonstrate the safety and efficacy of the GTU artificial urinary sphincter device in restoring continence in males who have confirmed urinary stress incontinence for a minimum of 12 months with primary etiology being radical prostatectomy or transurethral resection of the prostate (TURP).

St George Hospital
 (7.3 away) Contact site
  • 234 views
  • 07 Nov, 2020
  • +5 other locations
A Study to Establish the Feasibility of Biolen for the Local Delivery of Bicalutamide in Patients With Prostate Cancer

Biolen, a novel implant, is intended to deliver an anti-androgen locally to the prostate gland for the management of prostate disease, while minimizing systemic exposure and its associated side-effects. The objectives of the study are to assess whether the Biolen is safe.

antiandrogen therapy
bicalutamide
antiandrogens
cancer
prostatectomy
Australian Clinical Trials
 (5.1 away) Contact site
  • 50 views
  • 12 Aug, 2020
  • +3 other locations