North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 512 clinical trials
Efficacy and Safety of Pembrolizumab (MK-3475) With Lenvatinib (E7080/MK-7902) vs. Docetaxel in Participants With Metastatic Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease (PD) After Platinum Doublet Chemotherapy and Immunotherapy (MK-7902-008/E7080-G000-316/LEAP-008)

This study will evaluate the efficacy and safety of pembrolizumab (MK-3475) with lenvatinib (E7080/MK-7902) vs. docetaxel in participants with metastatic non-small cell lung cancer (NSCLC) and progressive disease (PD) after platinum doublet chemotherapy and treatment with one prior anti-PD-1/PD-L1 monoclonal antibody (mAb). The primary hypotheses of this study are that …

mk-3475
pd-l1
biomarker analysis
pembrolizumab
measurable disease
Westmead Hospital ( Site 0005)
 (7.7 away) Contact site
  • 122 views
  • 03 Dec, 2020
  • +134 other locations
Efficacy and Safety of Nemolizumab in Subjects With Moderate-to-Severe Atopic Dermatitis

Safety and efficacy of nemolizumab in subjects with moderate-to-severe atopic dermatitis

Galderma Investigational Site
 (7.7 away) Contact site
  • 95 views
  • 04 Dec, 2020
  • +236 other locations
Study of Efficacy Safety Tolerability Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody CFZ533 in Kidney Transplant Recipients

The purpose of this study is to investigate the safety, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of three CFZ533 dose regimens in kidney transplant recipients. This study will allow assessment of the ability of CFZ533 to replace Calcineurin inhibitors (CNIs) in terms of anti-rejection efficacy, while providing better renal function …

vaccination
calcineurin inhibitor
tacrolimus
monoclonal antibodies
immunization schedules
Novartis Investigative Site
 (7.3 away) Contact site
  • 31 views
  • 21 Oct, 2020
  • +85 other locations
Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion

The purpose of this study is to evaluate the efficacy and safety of brolucizumab in treatment of patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO).

macular edema
visual impairment
edema
venous obstruction
aflibercept
Novartis Investigative Site
 (6.6 away) Contact site
  • 28 views
  • 21 Sep, 2020
  • +117 other locations
A Study of ZN-c5 in Participants With Breast Cancer

This is a Phase 1 open-label, multicenter study to evaluate biomarkers for ZN-c5 in subjects with breast cancer

breast adenocarcinoma
estradiol
Site 9
 (1.3 away) Contact site
  • 37 views
  • 05 Nov, 2020
  • +16 other locations
RCT Cefiderocol vs BAT for Treatment of Gram Negative BSI

The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of care.

Western Sydney Local Health District (Westmead Hospital)
 (7.3 away) Contact site
  • 88 views
  • 02 Dec, 2019
  • +11 other locations
A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations

The purpose of this study is to evaluate the efficacy of erdafitinib in terms of overall response rate (ORR) in participants with advanced solid tumors with fibroblast growth factor receptor (FGFR) mutations and gene fusions.

cancer
solid tumour
measurable disease
growth factor
Chris O'Brien Lifehouse
 (7.3 away) Contact site
  • 33 views
  • 11 Nov, 2020
  • +253 other locations
A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)

The reason for the study is to find out if an experimental combination of an oral medication called osimertinib (TAGRISSO) when used in combination with chemotherapy is more effective than giving osimertinib alone for the treatment of locally advanced or metastatic non-small cell lung cancer. Some lung cancers are due …

stage iv non-small cell lung cancer
egfr t790m
growth factor
pemetrexed
carboplatin
Research Site
 (7.3 away) Contact site
  • 811 views
  • 28 Oct, 2020
  • +148 other locations
Study of GSK3359609 and Pembrolizumab in Programmed Death Receptor 1-ligand 1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

The purpose of study is to evaluate if the addition of GSK3359609 to pembrolizumab as first-line treatment improves the efficacy of pembrolizumab in participants with recurrent or metastatic (R/M) head and neck squamous cell carcinoma/cancer (HNSCC). This is a randomized, double-blind, adaptive Phase II/III study comparing a combination of GSK3359609 …

primary tumor
metastatic head and neck squamous cell carcinoma
human papillomavirus
oropharyngeal
pembrolizumab
GSK Investigational Site
 (4.8 away) Contact site
  • 6 views
  • 03 Dec, 2020
  • +168 other locations
Vedolizumab in the Prophylaxis of Intestinal Acute Graft Versus Host Disease (aGVHD) in Participants Undergoing Allogeneic Hematopoietic Stem Cell (Allo-HSCT) Transplantation

The purpose of this study is to evaluate the efficacy of vedolizumab when added to background aGvHD prophylaxis regimen compared to placebo and background aGvHD prophylaxis regimen on intestinal aGvHD-free survival by Day +180 in participants who receive allo-HSCT as treatment for a hematologic malignancy or myeloproliferative disorder.

Saint Vincent's Hospital Sydney
 (8.2 away) Contact site
  • 42 views
  • 28 Oct, 2020
  • +112 other locations