North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 512 clinical trials
Study to Assess Safety Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Participants With Locally Advanced or Metastatic Solid Tumors

The primary objective of this study is to determine the safety and tolerability of pamiparib, the maximum tolerated dose (MTD) or maximum administered dose (MAD) for pamiparib combined with TMZ, to select the recommended Phase 2 dose (RP2D) and schedule of pamiparib in combination with TMZ, and to determine the …

Chris O'Brien Lifehouse
 (7.5 away) Contact site
  • 28 views
  • 21 Sep, 2020
  • +20 other locations
Safety Pharmacokinetics (PK) and Efficacy of MK-1308 in Combination With Pembrolizumab (MK-3475) in Advanced Solid Tumors (MK-1308-001)

This study will assess the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of escalating doses of MK-1308 when used in combination with pembrolizumab in participants with advanced solid tumors.

Melanoma Institute Australia ( Site 0017)
 (5.0 away) Contact site
  • 742 views
  • 28 Oct, 2020
  • +45 other locations
Safety and Efficacy Study of Viaskin Peanut in Peanut-allergic Young Children 1-3 Years of Age

The study aims to assess the safety and efficacy of Viaskin Peanut to induce desensitization to peanut in peanut-allergic children 1 to 3 years of age after a 12-month treatment by EPicutaneous ImmunoTherapy (EPIT).

a 12
The Children's Hospital at Westmead
 (7.7 away) Contact site
  • 246 views
  • 01 Nov, 2020
  • +50 other locations
Plasma-Lyte 148 versUs Saline Study

The aim of PLUS is to conduct a multi-centre, blinded, randomised, controlled trial (RCT) to determine whether fluid resuscitation and therapy with a "balanced" crystalloid solution (Plasma-Lyte 148) decreases 90-day mortality in critically ill patients requiring fluid resuscitation when compared with the same treatment using 0.9% sodium chloride (saline)

Concord Repatriation General Hospital
 (3.5 away) Contact site
  • 0 views
  • 04 Oct, 2020
  • +52 other locations
Study of REGN2810 in Patients With Advanced Cutaneous Squamous Cell Carcinoma

For Groups 1 to 4, the primary objective of this study is to estimate the clinical benefit of cemiplimab monotherapy for patients with: metastatic (nodal or distant) cutaneous squamous cell carcinoma (CSCC), or unresectable locally advanced CSCC. For Group 6, the primary objective is to provide additional efficacy and safety …

Royal North Shore Hospital
 (4.8 away) Contact site
  • 0 views
  • 17 Nov, 2020
  • +100 other locations
A Trial to Evaluate the Efficacy and Safety of Tafasitamab With Bendamustine (BEN) Versus Rituximab (RTX) With BEN in Adult Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)

The purpose of the study is to compare the safety and efficacy of Tafasitamab with BEN versus RTX with BEN in adult patients with relapsed of refractory DLBCL.

diffuse large b-cell lymphoma refractory
gilbert's syndrome
rituximab
measurable disease
bendamustine
MorphoSys Research Site
 (4.8 away) Contact site
  • 0 views
  • 22 Mar, 2020
  • +152 other locations
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)

This is an open-label, randomized, multi-center, comparator Phase II trial looking at the addition of Bevacizumab to Vinblastine in chemotherapy nave pediatric patients with progressive Low Grade Glioma aged 6 months to less than18 years of age at the time of initiation of therapy. Participants will be randomized to Arm …

vinblastine
corticosteroids
platelet count
glomerular filtration rate
BRAF
Children's Hospital at Westmead
 (7.7 away) Contact site
  • 0 views
  • 16 Mar, 2020
  • +22 other locations
A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)

This is a prospective, multicenter, open-label, randomized, controlled, parallel group, group-sequential, event-driven Phase 3 study to evaluate efficacy, safety and pharmacokinetics (PK) of macitentan in children.

heart disease
macitentan
connective tissue disease
hypertension
Children's Hospital at Westmead
 (7.7 away) Contact site
  • 172 views
  • 03 Dec, 2020
  • +104 other locations
A Study of Bendamustine and Rituximab Alone Versus in Combination With Acalabrutinib in Subjects With Previously Untreated Mantle Cell Lymphoma

This study is evaluating the efficacy of acalabrutinib in combination with bendamustine and rituximab (BR) compared with placebo plus BR in subjects with previously untreated mantle cell lymphoma.

acalabrutinib
bendamustine
cyclin d1
rituximab
Research Site
 (4.8 away) Contact site
  • 1270 views
  • 30 Jul, 2020
  • +212 other locations
DS-8201a in Pre-treated HER2 Breast Cancer That Cannot be Surgically Removed or Has Spread [DESTINY-Breast02]

This study will compare DS 8201a to standard treatment. Participants must have HER2 breast cancer that has been treated before. Their cancer: cannot be removed by an operation has spread to other parts of the body

immunostimulant
HER2
capecitabine
her2/neu-positive breast cancer
trastuzumab
Macquarie University Hospital
 (1.3 away) Contact site
  • 132 views
  • 07 Oct, 2020
  • +69 other locations