North Ryde, Australia Clinical Trials

A listing of North Ryde, Australia clinical trials actively recruiting patients volunteers.

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Found 512 clinical trials
Interleukin 6 Blockade Modifying Antibody-Mediated Graft Injury and Estimated Glomerular Filtration Rate (eGFR) Decline

This trial investigates whether clazakizumab (an anti-interleukin (IL)-6 monoclonal antibody (mAb)) may be beneficial for the treatment of CABMR in recipients of a kidney transplant by inhibiting the production of Donor Specific Antibodies (DSA) and re-shaping T cell alloimmune responses.

Royal Prince Alfred Hospital
 (7.3 away) Contact site
  • 1 views
  • 17 Nov, 2020
  • +55 other locations
Spinal Deformity Intraoperative Monitoring.

A multicenter, international prospectively collected patient cohort undergoing high-risk spinal cord level surgery or spinal osteotomy procedures will be enrolled to establish the incidence of intraoperative alerts in high-risk spinal cord cases, and explore factors associated with mitigating injury. Baseline, intraoperative, and postoperative characteristics, including demographics, radiological features, lower extremity …

alerts
spondylolisthesis
spinal cord
radiculopathy
Royal North Shore Hospital
 (4.8 away) Contact site
  • 16 views
  • 02 Mar, 2020
  • +31 other locations
Long-term Safety Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

The purpose of this study is to collect long-term safety, tolerability, effectiveness and health outcomes data in eligible subjects who have participated in a Novartis ofatumumab clinical MS study. Vaccination sub-study The purpose of this research sub-study is to find out the effects of ofatumumab on the development of antibody …

ofatumumab
pneumococcal conjugate vaccine
tetanus
Novartis Investigative Site
 (4.8 away) Contact site
  • 234 views
  • 16 Nov, 2020
  • +260 other locations
Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE)

The primary objectives of the study by study part are: Part A: To determine the treatment effect of dupilumab compared with placebo in adult and adolescent patients with EoE after 24 weeks of treatment as assessed by histological and clinical measures and to inform/confirm the final sample size determination for …

dysphagia
endoscopic biopsy
Regeneron Study Site
 (7.3 away) Contact site
  • 300 views
  • 11 Nov, 2020
  • +82 other locations
A Phase III Study of Efficacy and Safety of Ligelizumab in the Treatment of CSU in Adolescents and Adults Inadequately Controlled With H1-antihistamines.

The purpose of this study is to establish efficacy and safety of ligelizumab in adolescent and adult subjects with CSU who remain symptomatic despite standard of care treatment by demonstrating better efficacy over omalizumab. The study population will consist of approximately 1050 male and female subjects aged 12 years who …

antihistamines
omalizumab
urticaria
ligelizumab
a 12
Novartis Investigative Site
 (8.2 away) Contact site
  • 614 views
  • 08 Oct, 2020
  • +195 other locations
A Medical Research Study Designed to Determine if Venglustat Can be a Future Treatment for ADPKD Patients

Primary Objective: To determine the effect of venglustat on the rate of total kidney volume (TKV) growth (Stage and estimated glomerular filtration rate (eGFR) decline in patients at risk of rapidly progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD) (Stage 2). Secondary Objectives: To determine the effect of venglustat on the …

treatment regimen
chronic kidney disease
ophthalmological examination
glomerular filtration rate
urine osmolality
Investigational Site Number 0360001
 (7.9 away) Contact site
  • 82 views
  • 04 Dec, 2020
  • +126 other locations
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require …

Concord Repatriation General Hospital
 (4.8 away) Contact site
  • 41 views
  • 05 Nov, 2020
  • +97 other locations
Thin Wire Versus Thick Wire Snare for Cold Snare Polypectomy of Diminutive Polyps

Cold snare polypectomy (CSP) is now common practice and has proven to be a safe and effective technique for removal of diminutive polyps. Both thick and thin wire snares are now commonly used for CSP. However, because of their physical characteristics, thick wire snares might leave a higher percentage of …

polypectomy
cancer
adenoma
endoscopy
Auburn Hosptial
 (6.4 away) Contact site
  • 50 views
  • 08 Jul, 2019
  • 1 location
High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

This is a randomized study of the European SIOP Neuroblastoma Group (SIOPEN) in high-risk neuroblastoma (stages 2, 3, 4 and 4s MYCN-amplified neuroblastoma, stage 4 MYCN non amplified > 12 months at diagnosis). The protocol consists of a rapid, dose intensive induction chemotherapy, peripheral blood stem cell harvest, attempted complete …

melphalan
metastatic neuroblastoma
high-risk neuroblastoma
etoposide
isotretinoin
Sydney Children's Hospital
 (7.3 away) Contact site
  • 288 views
  • 28 Oct, 2020
  • +125 other locations
A Randomized Trial of Pembrolizumab & Radiotherapy Versus Radiotherapy in High-Risk Soft Tissue Sarcoma of the Extremity

This is an open-label, multi-institutional phase II randomized study comparing neoadjuvant radiotherapy followed by surgical resection to neoadjuvant pembrolizumab with concurrent radiotherapy, followed by surgical resection and adjuvant pembrolizumab. The total duration of pembrolizumab will be one year in the experimental arm.

Chris O'Brien Hospital
 (7.5 away) Contact site
  • 56 views
  • 27 Jan, 2020
  • +16 other locations