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  • Yoga Nidra for Insomnia and Posttraumatic Stress Symptoms

    Participants will be randomly assigned to 1 of three groups: two remote yoga nidra interventions will be compared to a waitlist control group. The yoga nidra groups will be as follows: a high-dose condition in which participants will be instructed to engage in yoga nidra practice by listening to ~30-minute recordings every day for 8 weeks, and a low-dose condition in which participants will be instructed to engage in yoga nidra practice by listening to ~10-minute recordings 6 days per week and a ~30-minute recording one day per week for 8 weeks. The yoga nidra recordings are comprised of Integrative Restoration (iRest) yoga nidra scripts. Participants will be given the opportunity to listen to their provided recordings as often as they would like during the intervention. Frequency of practice sessions will be tracked on the website and recorded by participants in their daily surveys. In Week 10, participants in the waitlist control group will be randomly assigned to either low-dose or high-dose yoga nidra and given access to the recordings over the 8 weeks following the second PSG. Daily PTSD symptoms and sleep will be recorded for two weeks prior to the intervention (baseline weeks) and throughout the intervention. At-home polysomnography will be completed immediately prior to the intervention (Week 2) and immediately following the intervention (Week 10), and questionnaires will be completed during the in-lab electrode application and removal sessions for the at-home polysomnography. During the in-lab sessions, resting state electroencephalography (EEG), heart rate variability (HRV), and skin conductance levels will also be recorded. Follow-up questionnaires will be administered to all participants 8 weeks after the second sleep study (Week 18) to assess primary treatment outcomes and mindfulness in waitlist participants after the intervention and maintenance of primary treatment outcomes and mindfulness following the intervention in yoga nidra high- and low-dose participants.

    Phase

    N/A

    Span

    39 weeks

    Sponsor

    University College, London

    London

    Recruiting

  • A Simple Breath Test to Detect Liver Cancer and Monitor Liver Conditions

    Phase

    N/A

    Span

    107 weeks

    Sponsor

    Imperial College London

    London

    Recruiting

    Healthy Volunteers

  • Impact of Chronic Pulmonary Aspergillosis (CPA) on Health Status and Well-being

    Phase

    N/A

    Span

    74 weeks

    Sponsor

    Imperial College London

    London

    Recruiting

  • Optical Monitoring of Placental Oxygenation and Metabolism

    Phase

    N/A

    Span

    135 weeks

    Sponsor

    University College, London

    London

    Recruiting

  • A Health App Using Recipes and Education Components to Facilitate Sustainable and Healthier Diets.

    Overall aim: This pilot trial aims to understand the feasibility and acceptability of the syd app. The main focus is around the plant-based recipes and information pages delivered through the chat functionality. Specific objectives: The primary objective is to understand the feasibility and acceptability of setting up and running a trial with the syd app, focusing on the reach, adoption, implementation, and maintenance. The secondary objectives are to explore the indicative efficacy of the app in facilitating more sustainable and healthier diets, measured by a change in meat and legume intake, to what extent the recipes and information pages contribute to this effect, and whether there is a relationship between the self-perceived capabilities, opportunities and motivations to consume a sustainable and healthier diet. Intervention: The overall aim of syd is to enhance general wellbeing across nine domains, through completing activities and forming micro habits. The app has five main pages (Home, Daily Plan, Journal, Profile, and Chat). Users can input a goal, browse the 'activity pages', enter them into their daily plan, and complete them. When interacting with the app by completing activities, conversing in the chat, journaling or through other methods, the app calculates their 'life quality index' across all domains and presents this to users in the profile page. As the app focuses on multiple health behaviours rather than dietary change specifically, only some of the features are relevant to diet, mainly the 'activity pages' that contain food-related information and recipes. The information pages contain general information on certain aspects of diets for health and sustainability, quick tips in achieving dietary goals, and more detailed information on "What", "Why" and "How" one can adopt healthy dietary principles. The recipes are available for breakfast, lunch and dinner, and vary in their composition of healthy and sustainable foods. The chat function uses a large language model to converse and recommend content to users based on their engagement in the app overall, as well as the prompts users input into the chat. Sample size: The target sample size will be 99 (33 per arm), which will account for the possibility of 40% dropout in the first two weeks, which is typical for smartphone apps, and would still suffice the rule of thumb for 25 per group to be included in a pilot study to yield a small standardised effect size. Outcomes: Outcomes (and data) that will be collected and include 1) programme reach (population characteristics), 2) adoption of the app (participation and retention rates), 3) acceptability of the intervention (engagement with and usefulness of the app features), 4) implementation of delivering the intervention (compliance), 5) maintenance of the intervention (participant and organizational sustainability), and 6) efficacy of the intervention (indications of change in behavioural determinants and behaviours).

    Phase

    N/A

    Span

    19 weeks

    Sponsor

    London School of Hygiene and Tropical Medicine

    London

    Recruiting

    Healthy Volunteers

  • Wearable Devices for Patient Monitoring in Long QT Syndrome

    Phase

    N/A

    Span

    75 weeks

    Sponsor

    Queen Mary University of London

    London

    Recruiting

  • Anonymous Data Sharing for Small Bowel

    The investigators wish to share with collaborative partners selected fully anonymized MRI datasets and associated relevant clinical data (such as blood tests results, endoscopic findings, histology) acquired as part of routine clinical practice at UCH since 2005. The collaborative partners are: 1. The Centre for Medical Image Computing (CMIC) at UCL 2. A European consortium (including UCL as partner and UCLH as subcontractor) which has been awarded an FP7 European grant: University of Delph, Amsterdam medical centre, Eldgenössische Technische Hochschule Zürich, Switzerland, Zuse Institut Berlin, Germany, Biotronics3D Limited UK and Vodera Limited UK. The investigators wish to share a total of 75 datasets with the FP7 consortium and 300 with CMIC. Process for the sharing of anonymized datasets acquired as part of clinical practice. Many patients undergoing small bowel MRI at UCH often also undergo additional tests as part of their usual clinical care which are recognized as good standards of reference against which the investigators can validate our MRI findings. Notable examples are blood tests (eg CRP), and endoscopy and biopsy. Furthermore, many patients have normal examinations and these datasets are also very useful in software development to define a standard of normality. Suitable datasets will be found as follows: 1. Search of the PACS database to identify all small bowel examinations performed at UCH 2. Use clinical sources freely available to hospital clinical staff via the CDR web system at UCH to triage these patients into relevant clinical groups notably those who have normal small bowel examinations, and those with abnormal studies who have a relevant clinical standard of reference performed within 6 weeks (CRP level, endoscopy, biopsy) 3. Select a sample of relevant datasets for use in software development. The total number to be data shared with the FP7 consortium listed above will not exceed 75. The total number of datasets to be data shared with UCL (CMIC) will not exceed 300. The larger number shared with CMIC reflects their need for a large database of normal examinations to develop motility software.

    Phase

    N/A

    Span

    854 weeks

    Sponsor

    University College, London

    London

    Recruiting

    Healthy Volunteers

  • FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United Kingdom

    FECD is the most prevalent repeat expansion disease in humans. Clinical anticipation and intergenerational expansion of disease-associated repeats are features of other repeat expansion diseases, but this area has not been comprehensively addressed in FECD. Due to its insidious onset and slow disease progression, early diagnosis of FECD in pre-symptomatic patients is challenging. To gain insights into the variable penetrance of FECD and to identify early signs of the disease in genetically predisposed but asymptomatic individuals (i.e., a pre-symptomatic cohort), we aim to recruit biological relatives of FECD patients receiving care at study sites, as well as individuals with early-stage disease. By combining genotyping and clinical phenotyping, we seek to elucidate the underlying factors influencing disease manifestation. Our deep phenotyping approach encompasses an array of advanced imaging techniques such as visual acuity assessment, contrast sensitivity evaluation, slit-lamp photography, specular microscopy, Scheimpflug tomography, and anterior segment optical coherence tomography. These cutting-edge modalities enable the detection of subclinical corneal edema by revealing subtle changes in corneal shape, volume, and reflectivity at a high resolution. The imaging data obtained from participants will undergo meticulous quantitative analysis, allowing for the classification of anterior segment features and extraction of image-derived phenotypes. To capture the dynamic nature of FECD, eligible participants will be invited for follow-up examinations, facilitating a longitudinal assessment of disease progression.

    Phase

    N/A

    Span

    157 weeks

    Sponsor

    University College, London

    London

    Recruiting

  • A Trial of "APL-9796'' in Adults With Pulmonary Hypertension

    Phase

    2

    Span

    130 weeks

    Sponsor

    Apollo Therapeutics Ltd

    London

    Recruiting

  • Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs

    Growing evidence demonstrates the therapeutic potential of psychedelic substances, particularly psilocybin, in addressing mental health challenges and enhancing psychological well-being. While psychedelic experiences can catalyse profound positive changes, they can also be psychologically challenging and potentially destabilising, underscoring the need for thorough preparation. Studies consistently show that an individual's psychological state prior to psychedelic administration significantly influences both the acute experience and its lasting benefits. However, structured preparation protocols designed to optimise this pre-psychedelic state remain understudied despite their crucial role in therapeutic outcomes. Digital health interventions offer a promising solution for delivering standardised preparation protocols at scale. Meditation-based approaches warrant particular investigation, as they systematically cultivate both immediate psychological states and enduring traits (e.g. non-judgemental acceptance) beneficial for psychedelic experiences. Through regular practice, meditation promotes trait-like metacognitive awareness, emotional regulation, and tolerance of uncertainty - qualities particularly valuable for navigating altered states of consciousness. These benefits are supported by neuroscientific evidence showing that meditation and psychedelics influence similar brain networks and mechanisms. While traditional meditation training often requires substantial time investment and in-person instruction, digital platforms can provide efficient structured guidance without the need for face-to-face support from a trained instructor, while maintaining essential elements of practice. This combination of accessibility and evidence-based benefits makes digital meditation platforms particularly well-suited for preparing individuals for psychedelic experiences. This randomised controlled feasibility trial evaluates the Digital Intervention for Psychedelic Preparation (DIPP), a 21-day self-guided program. Forty healthy volunteers will be randomised 1:1 to either a meditation-based intervention or music-based control condition. Both groups will engage with identical program structures, differing only in their daily practice (meditation versus music listening). Following preparation, all participants will undergo a supervised 25 mg psilocybin session at University College London, with follow-up assessments conducted in person at 2 weeks and online at 3, 6, and 9 months post-intervention. The primary outcomes address two key aspects of feasibility: operational feasibility and intervention adherence. Operational feasibility evaluates study-wide metrics, including recruitment efficiency (target ≥1 participant per week) and participant retention (target ≥70% completion through the 2-week post-dose follow-up). Intervention adherence focuses on participant engagement with the DIPP activities (meditation or music listening), assessed through completion rates for daily sessions, mood check-ins, journal entries, and weekly tasks, with a target of ≥70% of participants achieving an average completion rate of 70% or higher. Secondary outcomes, reported descriptively for both conditions, include implementation measures such as subjective feasibility (SFIS), acceptability (TFA), and usability (SUS/MARS) ratings. Efficacy measures assess changes in psychedelic preparedness (PPS) from baseline to post-DIPP intervention, the qualities of the acute psychedelic experience (11-Dimensional Altered States of Consciousness Scale [11D-ASC] and Challenging Experience Questionnaire [CEQ]) following dosing, and changes in mental wellbeing (Warwick-Edinburgh Mental Wellbeing Scale [WEMWBS]) from baseline through the 2-week post-dose follow-up. As such, this study will investigate the feasibility of implementing a digital preparation protocol within a research setting, while gathering preliminary data on engagement, acceptability, and potential efficacy. The findings will inform refinements to the DIPP platform and protocol, supporting the development of accessible, standardised preparation methods for psychedelic research and therapy as the field continues to expand into diverse clinical and community-based settings.

    Phase

    1

    Span

    96 weeks

    Sponsor

    University College, London

    London

    Recruiting

    Healthy Volunteers

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