Essendon, Australia Clinical Trials

A listing of Essendon, Australia clinical trials actively recruiting patients volunteers.

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Found 235 clinical trials
Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease. The participant will either get semaglutide (active medicine) or placebo ("dummy" medicine). Which treatment the participants get is decided by chance. …

cardiovascular disease
body mass index
overweight or obesity
Novo Nordisk Investigational Site
 (6.7 away) Contact site
  • 7712 views
  • 16 Jun, 2021
  • +1164 other locations
Efficacy and Safety Study of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in ESA Na ve Subjects Who Require Red Blood Cell Transfusions

The study will be conducted in compliance with the International Council for Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements. This is an interventional active-controlled, open-label, randomized Phase 3 study to compare the efficacy and safety of luspatercept (ACE-536) …

bone marrow procedure
cancer
anemia
blood transfusion
erythropoietin
The Alfred Hospital
 (6.7 away) Contact site
  • 289 views
  • 13 May, 2021
  • +258 other locations
A Maintenance Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis

The purpose of this study is to evaluate the efficacy and safety of mirikizumab as maintenance therapy in participants who completed prior 12-week induction study AMAN (NCT03518086).

endoscopy
mirikizumab
Royal Melbourne Hospital
 (4.2 away) Contact site
  • 386 views
  • 15 Jun, 2021
  • +903 other locations
PeriOperative ISchemic Evaluation-3 Trial

This study is a multicentre, international, randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance strategy.

major surgery
hypertension
heart failure
coronary artery disease
diabetes
Royal Melbourne Hospital
 (3.4 away) Contact site
  • 897 views
  • 27 Apr, 2021
  • +173 other locations
Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B With or Without Inhibitory Antibodies to Factor VIII or IX

Primary Objective: To characterize the long-term safety and tolerability of fitusiran Secondary Objectives: To characterize the long-term efficacy of fitusiran as assessed by the frequency of: Bleeding episodes Spontaneous bleeding episodes Target joint bleeding episodes To characterize the effects of fitusiran on health-related quality of life (HRQOL) measures in participants …

severe haemophilia a
hemarthrosis
fitusiran
antihemophilic factor
Investigational Site Number '0360003
 (8.5 away) Contact site
  • 180 views
  • 12 Mar, 2021
  • +65 other locations
Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment

A global study to assess the efficacy and safety of durvalumab in combination with bevacizumab or durvalumab alone in patients with hepatocellular carcinoma who are at high risk of recurrence.

durvalumab
bevacizumab
Research Site
 (5.4 away) Contact site
  • 75 views
  • 16 Jun, 2021
  • +242 other locations
A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis

A double-blind placebo controlled randomized Phase 3 study to determine if 80 or 100 mg of MGL-3196 as compared with placebo resolves NASH on liver biopsy and prevents progression to cirrhosis and/or advanced liver disease

mri-pdff
liver disease
fibrosis
hepatic fibrosis
fibroscan
The Royal Melbourne Hospital
 (2.9 away) Contact site
  • 167 views
  • 12 Mar, 2021
  • +219 other locations
Tisagenlecleucel in Adult Patients With Aggressive B-cell Non-Hodgkin Lymphoma

This is a randomized, open label, multicenter phase III trial comparing the efficacy, safety, and tolerability of tisagenlecleucel to Standard Of Care in adult patients with aggressive B-cell Non-Hodgkin Lymphoma after failure of rituximab and anthracycline containing frontline immunochemotherapy.

anthracyclines
fludarabine
rituximab
high dose chemotherapy
carbon monoxide
Novartis Investigative Site
 (5.4 away) Contact site
  • 48 views
  • 16 Jun, 2021
  • +73 other locations
Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)

Few studies are specifically designed to address health concerns relevant during pregnancy. The consequence is a lack of evidence on best clinical practice. This includes mothers and their babies when pregnancy is complicated by an abnormally fast heart rate up to 300 beats per minute due to supraventricular tachyarrhythmia (SVA) …

The Royal Women's Hospital
 (5.2 away) Contact site
  • 317 views
  • 25 Jan, 2021
  • +42 other locations
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Participants With Metastatic Prostate Cancer

The purpose of this study is to evaluate the effectiveness of niraparib in combination with abiraterone acetate plus prednisone (AAP) compared to AAP plus placebo.

Peter MacCallum Cancer Centre
 (5.4 away) Contact site
  • 498 views
  • 26 Jan, 2021
  • +480 other locations