CenterWatch
  • Search Clinical Trials
  • Clinical Trial Listings
  • Volunteer
  • Learn About Clinical Trials

Adelaide, South Australia, Australia

< 2 Miles
Filters

Type

Distance
Age
0
0
Gender
Trial Phase
Sponsor
  • Sperm Selection for Infertility Treatment (SSA)

    Phase

    N/A

    Span

    231 weeks

    Sponsor

    Universidad Nacional de Córdoba

    Recruiting

    Healthy Volunteers

  • Responsive Web-based Roadmap (InT-mAp) in Infertility Treatment

    Phase

    N/A

    Span

    38 weeks

    Sponsor

    Maltepe University

    Recruiting

    Healthy Volunteers

  • FRIEND: Fibroids and Unexplained Infertility Treatment with Epigallocatechin Gallate; a Natural CompounD in Green Tea

    The objective of this study is to conduct a randomized double-blinded clinical trial to determine the effect of low caffeine green tea extract on fibroids and subsequent pregnancy in women seeking fertility treatment. The investigators hypothesize that EGCG in low caffeine green tea extract will reduce the fibroid size, improve the quality of endometrium, and increase the likelihood of pregnancy. To test this hypothesis, the investigators propose a randomized placebo-controlled clinical trial to evaluate live birth outcomes for women with unexplained infertility who have uterine fibroids. Participants will be randomized to either oral low caffeine green tea extract (1650mg/day) vs. placebo along ovarian stimulation with clomiphene citrate and timed intrauterine insemination for up to 4 cycles. Endpoints Primary Endpoint: - Our primary endpoint is cumulative live birth rate. Secondary Endpoints: - The conception rate. - The miscarriage rate. - The change of fibroid volume, symptom severity score, and health-related quality-of-life score, from baseline to completion of treatment, and endometrial receptivity biomarkers. - Time to pregnancy This will be a randomized, multi-center, prospective, and double-blind clinical trial of low caffeine green tea extract versus placebo. Fifty (50) participants will be randomized via computer-generated randomization schedule to receive either: 1. low caffeine green tea extract (1650mg in 6 capsules) taken orally on a daily basis along with Clomiphene citrate-intrauterine insemination (CC-IUI) cycle, up to 4 cycles if no pregnancy is achieved. Participant will stop green tea if she becomes pregnant. or 2. matched (smell, taste, color, texture) placebo capsules taken orally on a daily basis along with CC-IUI cycle, up to 4 cycles if no pregnancy is achieved. Participant will stop placebo if she becomes pregnant. The randomization scheme will be on a 3:1 basis in favor of green tea extract, thus 37 participants will be assigned to the first arm (green tea extract) and 13 participants to the second arm (placebo). Clomiphene citrate will be taken for 5 days on Day 3 +/- 2 days of the participant's cycle.

    Phase

    3

    Span

    195 weeks

    Sponsor

    Yale University

    Recruiting

1-3 of 3
CenterWatch

5000 Centregreen Way, Suite 200
Cary, NC, 27513, USA

Phone: 703.538.7600
Toll Free: 888.838.5578

  • Disclaimer
  • Privacy Policy
  • Term of Use
  • Do Not Sell My Personal Information