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Manic Disorders Clinical Trials

A listing of Manic Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (13) clinical trials

BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study

We propose to test the hypothesis that bezafibrate, a pan-PPAR agonist, may be effective and safe for bipolar depression with the following specific aims: Aim #1. Proof-of-Concept Safety and Tolerability Aim: To assess the safety and tolerability of bezafibrate added to anti-manic medication for bipolar depression, especially with regard to ...

Phase

Efficacy Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar Depression

This is a randomized, multiple dose, placebo-controlled, double-blind, multicentre study of Esketamine DPI, inhalation powder delivered via dry powder inhaler (DPI) in participants with TRBD. There are 3 study phases: Screening phase, a two weeks double-blind treatment phase and a 6-week follow-up phase. Participants are to be randomized in 1:1:1:1 ...

Phase

Saxenda in Obese or Overweight Patients With Stable Bipolar Disorder (Investigator Initiated)

BACKGROUND AND SIGNIFICANCE: Obesity is common among persons with severe mental illness (SMI), especially those with bipolar disorder (BP) (1-5). It is estimated that 45-55% of people with SMI are obese, making obesity 1.5-2 times more common among those with SMI than among the general population. Indeed, in a recent ...

Phase

Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics

Bipolar disorder (BD) is the Axis I psychiatric condition most strongly associated with substance use disorder (SUD); diagnostic co-occurrence is particularly high between BD and alcohol use disorder (AUD). Individuals with co-occurring SUD and BD (SUD+BD) have substantially worse clinical outcomes than those with either BD or SUD alone. Nonetheless, ...

Phase

A Probiotic Intervention to Prevent Relapse Following Hospitalization for Mania

Primary Aim 1. To determine if adjunctive probiotic administration can reduce relapse for participants first hospitalized for mania. Hypothesis: Participants receiving adjunctive probiotic microorganisms vs. adjunctive placebo will have a lower rate of relapse as defined by a re-hospitalization (e.g., admission to an inpatient unit) during the 24 week study ...

Phase

Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder

This study is a 7-day randomized, double-blind proof-of-concept pilot study of nitrous oxide vs. midazolam in 40 adults (20-60 years) with bipolar disorder (BD) (type I or II). Ongoing pharmacological and psychosocial treatments may continue, provided that they have not been initiated or significantly modified in the preceding 2 weeks. ...

Phase

Vortioxetine add-on Treatment Improves the Symptoms in Patients With Bipolar Depression

In this study, the investigators are going to examine the efficacy of vortioxetine augmentation in bipolar disorder patients with depressive symptoms. The study design is a double-blinded 6-week prospective study. It would be useful for clinicians because it will provide new evidence for the effect of vortioxetine in bipolar disorder ...

Phase

tDCS as an add-on Treatment for Resistant Major Depression in Uni- or Bipolar Patients

The aim is to investigate the effect of transcranial Direct Current Stimulation (tDCS) applied at the anodal left CDLPF of patients with resistant depression compared to patients treated with conventional therapy. The tDCS is used in add-on drug treatment in resistant depression stabilized for 4 weeks (antidepressant as SSRIs (Selective ...

Phase

Effects of Erythropoietin for Cognitive Side-effects of ECT

The trial will include patients with a diagnosis of major depression (MDD) unipolar disorder (UD) or bipolar disorder (BD) with a current moderate to severe depressive episode symptoms (a score of >17 on the Hamilton Depression Rating Scale 17-items (HRDS-17) scheduled for ECT treatment. Patients will be recruited from Psychiatric ...

Phase

Effects of Erythropoietin on Cognition and Neural Activity in Bipolar Disorder

This trial will include healthy first-degree relatives (sub-study 1) and bipolar disorder (BD) patients in partial or full remission (defined as a score of 14 on the Hamilton Depression Rating Scale 17-items and the Young Mania Rating Scale (sub-study 2) with objectively-verified cognitive dysfunction. Participants will be recruited from Psychiatric ...

Phase