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Manic Disorders Clinical Trials

A listing of Manic Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (159) clinical trials

Mechanism of Action of Electroconvulsive Therapy

This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar and bipolar depression receiving ECT. Patients will be scanned before and after a full course of ECT and clinical measures for depression severity and memory will be obtained at the same times.The project has ...

Phase N/A

A Study of Pregnant and Postpartum Women With and Without Mood Disorders

Postpartum Depression (PPD) is a serious syndrome which resembles a major depressive episode and occurs in 10-20% of all mothers in the year following delivery. In addition, 20 - 30 % of women with Bipolar Disorder will experience postpartum psychosis (mania) and at least 20 % will experience a postpartum ...

Phase N/A

Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipolar Depression

The study will evaluate the efficacy and safety of ITI-007 adjunctive to lithium or valproate in a randomized, double-blind, parallel-group, placebo-controlled, multi-center study in patients diagnosed with Bipolar I or Bipolar II disorder having a major depressive episode.


Efficacy Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar Depression

This is a randomized, multiple dose, placebo-controlled, double-blind, multicentre study of Esketamine DPI, inhalation powder delivered via dry powder inhaler (DPI) in participants with TRBD. There are 3 study phases: Screening phase, a two weeks double-blind treatment phase and a 6-week follow-up phase. Participants are to be randomized in 1:1:1:1 ...


Optimal Electrical Stimulus During Electroconvulsive Therapy

Purpose and aims The purpose of the study is to determine the electrical current stimulus for electroconvulsive therapy (ECT) that produces the optimal balance between antidepressant effect and memory disturbance. Specifically, this study aims to compare 0.5 ms and 1.0 ms pulse width stimuli. Primary objective: To test the hypothesis ...


Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder

The primary goals of this proof of concept study are to determine the effectiveness, safety and tolerability of FMT in adults with BD depression. Objective 1: To evaluate the effectiveness of the combination of a currently accepted approved therapy for BD depression + FMT in individuals with BD depression. This ...


Metformin for Overweight & OBese ChILdren and Adolescents With BDS Treated With SGAs

The investigators propose to recruit 1800 overweight/obese youth with Bipolar Spectrum Disorder (BSD) who are prescribed second generation anti psychotics (SGAs) from at least 24 public and private mental health practices in the Greater Cincinnati and New York City regions, (approximately 900 each from ~12 Cincinnati region and ~12 Long ...


Ketamine Versus Electroconvulsive Therapy in Depression

Worldwide, depression carries a significant burden. Although there are effective treatments for depression, many patients do not achieve remission, and any significant response usually occurs after a few weeks. The common approach for a rapid intervention in cases of severe depressive symptoms has been electroconvulsive therapy (ECT). There are drawbacks ...


Imaging 5HT7 Antagonist Effects in Bipolar Disorder

OBJECTIVE Primary To determine the effect of 5HT7 antagonism on cognition related brain activations and cognitive performance in people with bipolar disorder. Secondary To examine the effect of 5HT7 antagonism on emotional processing related brain activations in people with bipolar disorder. To examine the effect of 5HT7 antagonism on behavioral ...

Phase N/A

Wake Therapy in the Treatment of Depression

Both refractory depression and bipolar depression are difficult to treat. A night of complete sleep deprivation has been shown to result in marked improvement in 60% of depressed patients, although maintenance of therapeutic effects have not been sustained with wake therapy alone. This pilot study will assess the effectiveness of ...

Phase N/A