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Depression (Major/Severe) Clinical Trials

A listing of Depression (Major/Severe) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (57) clinical trials

The purpose of this study is to evaluate the efficacy, safety, and tolerability of levomilnacipran ER relative to placebo in adolescent outpatients (12-17 years) with Major Depressive Disorder (MDD). In addition, the study is designed to obtain pharmacokinetics (PK) data to guide dose selection for future pediatric studies of levomilnacipran.

Phase

Dr. Charles Conway is conducting a research study looking at adaptive enhanced transcranial direct current stimulation (tDCS) as adjunctive therapy for major depression. This study lasts 6 weeks. There will be up to 24 study visits that will last 30 minutes to 3 hours each. Participants will undergo 20 sessions ...

Phase N/A

This study will evaluate the efficacy, safety and tolerability of rapastinel 450 milligrams (mg) intravenous (IV) once weekly or once every 2 weeks versus placebo as an adjunctive treatment to ongoing anti-depressive therapy (ADT) in the prevention of relapse in participants with Major Depressive Disorder (MDD).

Phase

This study will assess the safety and efficacy of an investigational medication in patients with Major Depressive Disorder who have had a partial response to their antidepressant treatment. Each patient will receive a weekly intravenous dose of the investigational medication in addition to the current dose of their antidepressant.

Phase N/A

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MUTLICENTER STUDY OF RAPASTINEL AS ADJUNCTIVE THERAPY IN MAJOR DEPRESSIVE DISORDER

Phase

A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MUTLICENTER STUDY OF RAPASTINEL AS ADJUNCTIVE THERAPY IN MAJOR DEPRESSIVE DISORDER

Phase

The purpose of this study is to evaluate the efficacy of sirukumab as adjunctive treatment to antidepressant therapy, where sirukumab is measured over a 12 week study period for treatment of depression symptoms.

Phase

The purpose of the study aims to determine whether different concentrations of nitrous oxide (N2O) have different antidepressant effects for adults with treatment-resistant major depression. There are up to 14 study visits ranging from 1 to 4 hours each. There will be vital sign collection, and questionnaires throughout the study. ...

Phase N/A

California Neuroscience Research is conducting a research study to evaluate an investigational medication in persons with treatment resistant Major Depressive Disorder. Study Description A Randomized, Double-blind, Active- controlled Trial to Assess the Efficacy and Safety of Administered Orally to Subjects with Treatment Resistant Major Depressive Disorder.

Phase N/A

A Research Study is being conducted to evaluate an investigational product to be used for the treatment of Major Depressive Disorder (or MDD) in women. Qualified participants receive study-related care, and exams at no charge, in addition to compensation for time and effort.

Phase N/A