Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 856 clinical trials
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Study of the Association Between Tumor Microenvironment Macrophages and Treatment Response in Squamous Cell Carcinoma of the Anal Canal

chemotherapy for locally advanced tumors (T2 or more corresponding to a size of 2 cm or more, or N+): mitomycin C and 5-FU (or capecitabine). While the 5-year disease control rates are excellent in localized

chemotherapy regimen
human papillomavirus
squamous cell carcinoma
mitomycin
lung cancer
  • 0 views
  • 29 Aug, 2021
  • 1 location
None
PRecision Oncology CUhk pRogrammE (PRO-CURE)

The main aim of this project is to establish an innovative model of a comprehensive precision oncology platform to help individualizing drug therapy for patients with advanced cancers at The

  • 0 views
  • 16 May, 2021
  • 1 location
None
Study of Circulating Tumor DNA (ctDNA) Kinetics in Immuno-oncology (IO-KIN)

This study aims to study the kinetics of ctDNA levels after the first dose of immune checkpoint inhibitor in patients with recurrent or metastatic head and neck cancer. This is an important study to understand the optimal timing for ctDNA quantitation for future studies in immunotherapy, though further validation would …

neck cancer
metastatic head and neck cancer
head and neck cancer
nivolumab
cavities
  • 0 views
  • 07 May, 2021
  • 1 location
None
Monitoring of Circulating Tumor DNA and Its Aberrant Methylation in the Surveillance of Surgical Lung Cancer Patients (MEDAL MEthylation Based Dynamic Analysis for Lung Cancer).

Conduct a prospective study to confirm the value of circulating tumor DNA and its aberrant methylation in longitudinal monitoring of surgical lung cancer patients.

lung cancer
lung carcinoma
cancer
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Crizotinib in ALK Rearranged Non-small-cell Lung Cancer

This is a multicenter, observational, retrospective cohort study aimed at assessing the efficacy and safety of crizotinib in ALK positive NSCLC treated in real life setting.

crizotinib
lung cancer
metastasis
stage iv non-small cell lung cancer
lung carcinoma
  • 0 views
  • 24 Jan, 2021
  • 21 locations
None
Study on Predictive Biomarkers of Neoadjuvant Chemoradiotherapy for Rectal Cancer

Backgrounds: A multicenter randomized phase III trial (NCT02605265) proved that adding irinotecan guided by UGT1A1 to capecitabine-based neoadjuvant chemoradiotherapy significantly increases complete tumor response. The treatment toxicities were increased but tolerable. Purposes: This study aims to identify the predictive biomarkers (from patients' tumor biopsy samples and peripheral blood samples before …

chemotherapy regimen
rectal cancer
cancer treatment
adenocarcinoma
cancer
  • 1 views
  • 23 Jan, 2021
  • 1 location
None
Identification of Prognostic Biomarkers for Progression of Invasive Squamous Cell Carcinoma

The study will utilize both retrospective and prospective data collection from patients that already had a bronchoscopy and lung resection or will have a bronchoscopy and lung resection for squamous cell carcinoma. The investigators plan to prospectively collect 5 bronchoscopic biopsies, 10ml blood and one tumor and adjacent normal samples …

squamous cell carcinoma
cancer
bronchoscopy
squamous cell carcinoma of lung
pulmonary resection
  • 1 views
  • 27 Sep, 2021
  • 1 location
None
Detecting Chemosensitivity and Predicting Treatmemt Efficacy With CTCs in mNPC

The prospective observational clinical study will recruit 50 metastatic nasopharyngeal carcinoma (mNPC) patients, detecting patient's chemosensitivity with the circulating tumor cells (CTCs) from peripheral blood and prdicting patient's treatment efficacy with CTCs dynamic change.

chemotherapy regimen
docetaxel
carcinoma
mnpc
iv infusion
  • 0 views
  • 20 Aug, 2021
  • 1 location
None
Systematic Evaluation of Human Explant Model Systems Engineering

therapy is of particular importance for patients, both with regard to the development of resistance and the side effect profile. This applies in particular to immunotherapies and their use in advanced

  • 0 views
  • 28 Jan, 2021
  • 1 location
None
Ultrasound Spectroscopy as Indicators of Radiation Treatment Response in Prostate Rectum and Head & Neck Cancers

to apoptotic, necrotic and mitotic cell death. The objectives of this study are to evaluate the use of ultrasound imaging and spectroscopy as a predictive marker of advanced tumour response to

measurable disease
renal function
head and neck carcinoma
carcinoma
neutrophil count
  • 0 views
  • 26 Jan, 2021
  • 1 location