Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 804 clinical trials
First-in-Human Study of ICT01 in Patients With Advanced Cancer

Part 1 will be a dose escalation study of IV ICT01 (a monoclonal antibody targeting BTN3A) as monotherapy in patients with advanced solid or hematologic tumors, followed by a cohort examining the combination of ICT01 plus pembrolizumab (Keytruda). Part 2 will be a cohort expansion into 2-3 solid tumor indications …

leukemia
measurable disease
follicular lymphoma
solid tumour
hematologic malignancy
  • 1 views
  • 04 May, 2021
  • 6 locations
Study of DCC-3014 in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor

This is a multicenter, open-label Phase 1/2 study of DCC-3014 in patients with malignant solid tumors and tenosynovial giant cell tumor (TGCT). There will be 2 distinct parts in this study: Dose Escalation (Phase 1) and Expansion (Phase 2). Phase 1 will enroll both malignant solid tumor and TGCT patients. …

solid tumor
measurable disease
solid neoplasm
  • 104 views
  • 31 Dec, 2021
  • 24 locations
Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations

This BVD-523-ABC study builds on the safety and clinical activity experience of previous studies that have evaluated ulixertinib as a novel targeted cancer treatment in cohorts of patients with specific genetic alterations and tumor histologies that result in aberrant MAPK pathway signaling. Early clinical data have demonstrated anti-tumor activity with …

  • 0 views
  • 04 Jan, 2022
  • 24 locations
Enhanced Supportive Care for Advanced Cancer Patients: Evaluation of Standardized Care Pathway

The purpose of this study is to evaluate the efficacy of the standardized care pathway which provides enhanced supportive care for patients with advanced cancer. A pilot study (single arm

  • 0 views
  • 01 Aug, 2021
  • 1 location
International Study to Evaluate Two Programs of Support for Patients With Advanced Cancer and Their Families

FOCUS+ and an eHealth intervention called iFOCUS) aimed at improving the emotional function and self-efficacy of patients with advanced cancer and their family caregiver. Both interventions are compared

  • 0 views
  • 31 Dec, 2021
  • 12 locations
Lay Coach-Led Early Palliative Care for Underserved Advanced Cancer Caregivers: The Project ENABLE Cornerstone RCT

Many of the 2.8 million family caregivers (FCGs) of persons with advanced cancer are underserved, particularly African-Americans and rural-dwellers in the Southern U.S.. Most have poor access

Accepts healthy volunteers
  • 0 views
  • 14 Dec, 2021
  • 1 location
Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers

CK-301 (cosibelimab) is a fully human monoclonal antibody of IgG1 subtype that directly binds to Programmed Death-Ligand 1 (PD-L1) and blocks its interactions with the Programmed Death-1 (PD-1) and B7.1 receptors. The primary objectives of this study are to assess the safety, tolerability and efficacy of CK-301 when administered intravenously …

kidney function test
lung carcinoma
metastasis
metastatic transitional cell carcinoma
transitional cell carcinoma
  • 1986 views
  • 19 Jan, 2022
  • 30 locations
Safety and Efficacy Study of SAR442720 in Combination With Pembrolizumab in Advanced Malignancies

Primary Objective: Part 1: To characterize the safety and tolerability of SAR442720 in combination with pembrolizumab in patients with advanced solid tumors including NSCLC who progressed on anti-PD-1/PD L1 containing therapy and advanced colorectal cancer (CRC) after progression to all standard of care (SOC) therapy. To define the MTD and …

measurable disease
KRAS
solid neoplasm
cancer
pembrolizumab
  • 0 views
  • 20 Jan, 2022
  • 24 locations
Safety and Efficacy Study of SAR442720 in Combination With Pembrolizumab in Advanced Malignancies

Primary Objective: Part 1: To characterize the safety and tolerability of SAR442720 in combination with pembrolizumab in patients with advanced solid tumors including NSCLC who progressed on anti-PD-1/PD L1 containing therapy and advanced colorectal cancer (CRC) after progression to all standard of care (SOC) therapy. To define the MTD and …

BRAF
measurable disease
KRAS
cancer
  • 0 views
  • 22 Jan, 2022
  • 14 locations
Safety and Efficacy of MAK683 in Adult Patients With Advanced Malignancies

(PK) profile of MAK683 in patients with advanced malignancies such as Diffuse Large B cell Lymphoma (DLBCL), nasopharyngeal carcinoma (NPC) or other advanced solid tumors for whom no further effective

measurable disease
hodgkin's disease
cancer
b-cell lymphoma
  • 133 views
  • 27 Jan, 2022
  • 14 locations