Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 804 clinical trials
Study to Evaluate the Safety and Efficacy of Treatment With NLM-001 and Standard Chemotherapy Plus Zalifrelimab in Patients With Advanced Pancreatic Cancer

In order to improve the survival rates and decrease progression of pancreatic advanced cancer, this study aims to evaluate the first line treatment approved for this disease (gemcitabine plus

  • 19 Jan, 2022
  • 4 locations
A First in Human Study of BAY2701439 to Look at Safety, How the Body Absorbs, Distributes and Excretes the Drug, and How Well the Drug Works in Participants With Advanced Cancer Expressing the HER2 Protein

In this study, researchers want to learn about the safety of drug BAY2701439 and how well the drug works in patients with advanced cancer that has the protein HER2 (Human Epidermal growth factor

  • 06 Jan, 2022
  • 1 location
Open-label Dose Escalation Phase 1b Trial of a New Micellar Docetaxel Compound in Patients With mCRPC

bone-damaging effects. There is an unmet medical need to develop steroid-free taxane regimens for patients with advanced cancer to avoid the need for steroid administration pre and post infusion

  • 07 Jan, 2022
  • 3 locations
  • 09 Jan, 2022
  • 8 locations
Safety and Efficacy of KY1044 and Atezolizumab in Advanced Cancer

selected advanced malignancies, who are ineligible for or there are no available therapies known to confer a clinical benefit for their disease, or they have exhausted all such available options in each

breast cancer
measurable disease
lung cancer
monoclonal antibodies
  • 13 Dec, 2021
  • 10 locations
Molecular Detection of Advanced Neoplasia in Pancreatic Cysts

Researchers are trying to find out whether new tests ("biomarkers") of blood, stool, pancreas cyst fluid, or pancreas juice can be used to diagnose malignant or pre-malignant changes in pancreas cysts.

  • 15 Jan, 2022
  • 1 location
A Study of ASP1570 in Adults With Advanced Solid Tumors

Part 1 without getting major medical problems. Some groups of people will have specific advanced tumors. These include tumors from metastatic melanoma or non-small cell lung cancer (NSCLC for short

  • 21 Jan, 2022
  • 3 locations
A Safety Study of SEA-TGT (SGN-TGT) in Advanced Cancer

This trial will look at a drug called SEA-TGT (also known as SGN-TGT) to find out whether it is safe for patients with solid tumors and lymphomas. It will study SEA-TGT to find out what its side effects are. A side effect is anything the drug does besides treating cancer. …

peripheral t-cell lymphoma
diffuse large b-cell lymphoma
combination chemotherapy
  • 20 Dec, 2021
  • 27 locations
Sasanlimab (PF-06801591, PD-1 Inhibitor) in Participants With Advanced Malignancies

with advanced malignancies. This study consists of 2 parts: Phase 1b part (dose escalation and dose expansion) in patients with advanced malignancies in Asia and a global Phase 2 part in

proto-oncogene tyrosine-protein kinase ros
measurable disease
pd-1 inhibitor
monoclonal antibodies
  • 24 Dec, 2021
  • 51 locations
A Study of Oral Tazemetostat in Subjects With Moderate and Severe Hepatic Impairment With Advanced Malignancies

This is a phase 1, 2-part, global, multicenter, open-label, PK, safety and tolerability study of oral tazemetostat in subjects with either advanced solid tumors, or hematological malignancies and normal hepatic function or moderate, or severe hepatic impairment.

measurable disease
serum pregnancy test
renal function
  • 18 Dec, 2021
  • 11 locations