Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 856 clinical trials
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The Recombinant Humanized Anti-TIGIT Monoclonal Antibody (JS006) Monotherapy and in Combination With Toripalimab in Patients With Advanced Tumor

with advanced tumors who have failed standard therapies or who have no standard therapy. It is planned to enroll 69-176 patients into the study.

  • 0 views
  • 06 Oct, 2021
  • 1 location
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A Study of Bispecific Antibody QLS31901 in Patients With Advanced or Metastatic Malignancies

This is a Phase 1, open label, non-randomised, dose-escalation single agent study with expansion cohorts for dose confirmation/safety and preliminary efficacy of QLS31901 in advanced or metastatic malignancies

  • 0 views
  • 30 Sep, 2021
  • 1 location
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An Explorative Study of Afatinib in the Treatment of Advanced Cancer Carrying an EGFR a HER2 or a HER3 Mutation

Objective(s):To investigate the efficacy and safety of afatinib in EGFR, HER 2 and HER3 mutated cancers, regardless of cancer type, excluding EGFR mutated non-small cell lung cancer. Methodology:Open label, genomic driven trial (basket trial) No. of patients total entered:Optimal Simon two stage design for the three genetic driven cohorts: 10 …

  • 1 views
  • 22 Jan, 2021
  • 5 locations
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Study of REGN5093-M114 (METxMET Antibody-Drug Conjugate) in Adult Patients With Mesenchymal Epithelial Transition Factor (MET) Overexpressing Advanced Cancer

The primary objective of the dose escalation (phase 1) part of the study is: To assess the safety, tolerability and pharmacokinetics (PK) of the antibody drug conjugate (ADC) REGN5093-M114 in order to determine a maximum tolerated dose (MTD) and/or define the recommended phase 2 dose (RP2D) of REGN5093-M114 in patients …

  • 0 views
  • 20 Oct, 2021
  • 1 location
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CRAFT: The NCT-PMO-1602 Phase II Trial

to investigate the efficacy of targeted-therapy plus immune checkpoint inhibition in patients with advanced tumors exhibiting one of the following genetic alterations detected within the NCT/DKTK

  • 0 views
  • 18 Nov, 2021
  • 4 locations
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A Study to Test Different Doses of BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors)

This study is open to adults with advanced cancer (solid tumors). People for whom previous treatment was not successful can take part in this study. The purpose of this study is to find

carcinoma
adenocarcinoma
primary cancer
bone marrow procedure
advanced cancer
  • 0 views
  • 26 Nov, 2021
  • 5 locations
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A Study of SBT6050 Alone and in Combination With PD-1 Inhibitors in Subjects With Advanced HER2 Expressing Solid Tumors

A first-in-human (FIH) study using SBT6050 and SBT6050 in combination with PD-1 inhibitors in HER2 expressing or amplified advanced malignancies

  • 0 views
  • 07 Oct, 2021
  • 10 locations
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A Study to Evaluate the Tolerance and Pharmacokinetics of TQB2858 Injection in Subjects With Terminal Malignant Tumors

This study is a phase I study to evaluate the safety and tolerability of TQB2858 injection in patients with advanced malignancy.

  • 0 views
  • 14 Jun, 2021
  • 1 location
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Intervention Toward Truth-Telling and Advanced Directives in the Patient With Advanced or Metastatic Disease

Family usually had a lot of burden to tell the truth to patients. The purpose of this study is to assess the effect of education materials and family conference for advanced cancer

metastasis
cancer
advanced cancer
  • 9 views
  • 07 Nov, 2020
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Study to Evaluate the Safety and Efficacy of Treatment With NLM-001 and Standard Chemotherapy Plus Zalifrelimab in Patients With Advanced Pancreatic Cancer

In order to improve the survival rates and decrease progression of pancreatic advanced cancer, this study aims to evaluate the first line treatment approved for this disease (gemcitabine plus

  • 0 views
  • 30 Oct, 2021
  • 4 locations