Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 100 clinical trials
Intratumoral Injection of LTX-315 in Combination With Pembrolizumab in Percutaneously Accessible Advanced Solid Tumors (ATLAS-IT-05)

ATLAS-IT-05 is an open-label, single-arm study in patients with superficial advanced solid tumors accessible for injection (cutaneous, subcutaneous, lymph node, or intramuscular tumors) and who have either exhausted treatment options or are not eligible for, suitable for, or willing to undergo such treatments.

  • 0 views
  • 12 Sep, 2021
  • 1 location
Phase I Trial of PCLX-001 in B-cell Non-Hodgkin Lymphoma and Advanced Solid Malignancies

This is a phase I dose-escalation study of oral PCLX-001, conducted in a multicenter, non-randomized, open-label, non-controlled design. The study is comprised of two parts: Part A (single-agent dose escalation) and Part B (single-agent expansion cohorts).

beta human chorionic gonadotropin
large b-cell lymphoma
platelet count
measurable disease
neutrophil count
  • 0 views
  • 19 Sep, 2021
  • 1 location
Study of RP-6306 in Advanced Solid Tumors

The primary purpose of this study is to assess the safety and tolerability of RP-6306 in patients with eligible advanced solid tumors, determine the maximum tolerated dose (MTD) and assess preliminary anti-tumor activity.

  • 0 views
  • 19 Sep, 2021
Lurbinectedin With Berzosertib an ATR Kinase Inhibitor in Small Cell Cancers and High-Grade Neuroendocrine Cancers

Background Small cell lung cancer (SCLC) and high-grade neuroendocrine cancers (HGNEC) are aggressive neuroendocrine cancers. At first, SCLC and HGNEC respond to chemotherapy. But then they relapse quickly and become resistant to treatment. Researchers want to see if a combination of drugs can help. Objective To see if the combination …

lurbinectedin
cancer chemotherapy
measurable disease
kinase inhibitor
neutrophil count
  • 0 views
  • 12 Sep, 2021
  • 1 location
A Study of SY 5609 a Selective CDK7 Inhibitor in Advanced Solid Tumors

This is a dose escalation study and will be the first to administer SY-5609 alone to humans with select advanced solid tumors and in combination with Fulvestrant to patients with HR positive, HER2-negative breast cancer.

estrogen
solid tumour
hormone therapy
fulvestrant
her2/neu-negative breast cancer
  • 0 views
  • 19 Sep, 2021
  • 7 locations
Phase 1 Study of BAY1905254 - An Early Clinical Research Study to Evaluate a New Drug Called Bapotulimab (BAY1905254) in the Expansion Cohort in Combination With Pembolizumab in Head and Neck Cancer That Has Returned or is Discovered to be Metastatic and is Expressing PDL1.

This study is being done to learn more about a new drug called Bapotulimab given in combination with Pembrolizumab. The purpose of this study is to learn if this new combination of drugs is safe for the participants, how it affects the body and to try to find the best …

cancer
pembrolizumab
antineoplastic
renal function
  • 46 views
  • 18 Sep, 2021
  • 12 locations
Olaparib in Treating Patients With Advanced Glioma Cholangiocarcinoma or Solid Tumors With IDH1 or IDH2 Mutations

This phase II trial studies how well olaparib works in treating patients with glioma, cholangiocarcinoma, or solid tumors with IDH1 or IDH2 mutations that have spread to other places in the body (metastatic) and usually cannot be cured or controlled with treatment (refractory). Olaparib may stop the growth of tumor …

solid tumour
serum pregnancy test
platelet count
solid tumor
luteinizing hormone
  • 110 views
  • 17 Sep, 2021
  • 25 locations
A Study of KF-0210 in Advanced Solid Tumors Patients

The purpose of this Phase I, Multi-Center, Open-Label Study is to evaluate the safety, tolerability, Pharmacokinetics, Pharmacodynamics and anti-tumor activity of KF-0210 in participants with advanced solid tumors. The study will be conducted in two parts: phase Ia, and phase Ib.

atezolizumab
measurable disease
  • 1 views
  • 11 Sep, 2021
  • 1 location
A Study of Penpulimab (AK105) in the First-line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma

This study is a randomized, double-blind, multi-center phase III clinical study to compare the efficacy and safety of penpulimab combined with chemotherapy and placebo combined with chemotherapy in the first-line treatment of recurrent or metastatic nasopharyngeal carcinoma.

carcinoma
chemotherapy regimen
immunomodulator
nasopharyngeal carcinoma
metastatic nasopharyngeal carcinoma
  • 0 views
  • 07 Sep, 2021
  • 29 locations
Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

This phase II trial studies how well adavosertib works in treating patients with SETD2-deficient solid tumors that have spread to other places in the body (advanced/metastatic). Adavosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

carcinoma
solid tumour
tumor cells
kinase inhibitor
neutrophil count
  • 37 views
  • 17 Sep, 2021
  • 19 locations