Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 100 clinical trials
TSR-042 as Maintenance Therapy for Patients With High-risk Locally Advanced Cervical Cancer After Chemo-radiation (ATOMICC)

Patients with locally advanced cervical cancer (LACC) despite definitive chemo-radiotherapy, has a poor progression-free survival (PFS) and overall survival (OS). The hypothesis is that the use of TSR-042, checkpoint inhibitor, as consolidation therapy following concurrent chemo-radiation would increase PFS in these patients. The incorporation of immunotherapy after chemo-radiation is one …

adenocarcinoma
ct scan
direct bilirubin
durvalumab
squamous cell carcinoma
  • 34 views
  • 16 Sep, 2021
  • 32 locations
A Study of an Intratumoral Oncolytic Virus in Patients With Advanced Metastatic Solid Tumors

The purpose of this study is to assess the safety and tolerability of ASP9801 and to determine the recommended phase 2 dose (RP2D). The study will also evaluate antitumor activity, objective response rate, pharmacokinetics and virus shedding of ASP9801.

solid tumor
measurable disease
solid neoplasm
  • 18 views
  • 19 Sep, 2021
  • 20 locations
A Study of JNJ-69086420 an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer

The purpose of this study is to determine the recommended Phase 2 dose(s) (RP2D[s]) of JNJ-69086420 in Part 1 (Dose Escalation) and to determine safety and and preliminary signs of clinical activity at the RP2D(s) in Part 2 (Dose Expansion).

adenocarcinoma
chemotherapy regimen
administration intravenous
cancer
  • 0 views
  • 17 Sep, 2021
  • 7 locations
A Study to Find the Best Dose of BI 1387446 Alone or in Combination With Ezabenlimab (BI 754091) in Patients With Different Types of Advanced or Metastatic Cancer (Solid Tumors)

This is a study in adults with advanced cancer (solid tumours) in whom previous treatment was not successful. The study tests 2 medicines called BI 1387446 and BI 754091. Both medicines may help

metastatic malignant solid tumor
solid neoplasm
solid tumor
primary cancer
bone marrow procedure
  • 0 views
  • 17 Sep, 2021
  • 8 locations
Combination Nilotinib and Paclitaxel in Adults With Relapsed Solid Tumors

what doses of the drugs can be given safely to people. Eligibility Adults at least 18 years old with advanced cancer that has progressed after

major surgery
neutrophil count
paclitaxel
liver metastasis
mitomycin
  • 0 views
  • 12 Sep, 2021
  • 1 location
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

and older who have advanced cancer that has gotten worse after standard treatment, or for which no effective therapy exists Design Participants will be screened

bone metastases
solid neoplasm
neutrophil count
liver metastasis
tumor growth
  • 128 views
  • 12 Sep, 2021
  • 1 location
Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT

non-small cell lung cancers. It is investigational to use these drugs in combination with each other in various types of advanced cancers. The study doctor can describe how the study drugs are

serum total bilirubin
lung cancer
neutrophil count
valvular heart disease
liver metastases
  • 57 views
  • 07 Sep, 2021
  • 1 location
Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel

who have a rare, advanced cancer that has progressed after receiving standard treatment, or for which no effective therapy exists. Design Participants will be

adenocarcinoma
neutrophil count
paclitaxel
primary cancer
bisphosphonate
  • 0 views
  • 12 Sep, 2021
  • 1 location
A Study of MPT-0118 in Subjects With Advanced or Metastatic Refractory Solid Tumors

This is a Phase 1/1b open-label, dose-escalation, and cohort expansion study with BID (tablet) oral dose of MPT-0118 in subjects with advanced or metastatic refractory solid tumors. The study will be conducted in 3 parts: Part A: MPT-0118 dose-escalation Part B: MPT-0118 dose-escalation in combination with pembrolizumab Part C: Cohort …

solid tumor
measurable disease
  • 0 views
  • 19 Sep, 2021
  • 5 locations
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced Metastatic or Unresectable Cancer

This phase Ib trial studies the side effects of nivolumab and to see how well it works in treating patients with autoimmune disorders and cancer that has spread to other places in the body or cannot removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's …

ct scan
lung cancer
interleukin-2
gastric cancer
neutrophil count
  • 619 views
  • 19 Sep, 2021
  • 30 locations