Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 122 clinical trials
A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies

of AB308 in combination with zimberelimab (AB122) in participants with advanced malignancies.

  • 0 views
  • 26 Jul, 2021
  • 11 locations
Effect of Laser Acupuncture on Constipation in Patients With Advanced Cancer

Constipation is one of the most common complications in patients with advanced cancer. The aim of this protocol designed as a double-blind randomized controlled trial is to investigate

cancer
laxative
other laxatives
  • 0 views
  • 26 Jul, 2021
  • 1 location
Study to Evaluate the Safety and Tolerability of RXC004 in Advanced Malignancies

The purpose of this study is to determine the safety and tolerability of RXC004 as monotherapy and in combination with Nivolumab in patients with advanced malignancies. In order to define the

conventional treatment
cancer
primary cancer
  • 13 views
  • 01 Aug, 2021
  • 5 locations
CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers

with select advanced cancers. CPI-006 will be evaluated as a single agent, in combination with ciforadenant (an oral adenosine 2A receptor antagonist), in combination with pembrolizumab (an anti-PD1

sarcoma
measurable disease
colorectal neoplasm
pembrolizumab
triple negative breast cancer
  • 1241 views
  • 01 Aug, 2021
  • 27 locations
TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

This is a phase 1/1b open label, multicenter dose escalation and dose expansion study to investigate the safety, tolerability and anti-tumor activity of TPST-1120, a small molecule selective antagonist of PPAR (peroxisome proliferator activated receptor alpha) as monotherapy and in combination with a systemic anticancer agent, nivolumab, an anti-PD1 antibody, …

sarcoma
measurable disease
head and neck carcinoma
progressive disease
bladder cancer
  • 86 views
  • 25 Jul, 2021
  • 13 locations
A Study to Evaluate the Safety and Tolerability of AB154 in Participants With Advanced Malignancies

This is a Phase 1, multicenter, open-label, dose-escalation study to evaluate the safety, tolerability, PK, PD, and clinical activity of domvanalimab (AB154) as monotherapy and in combination with zimberelimab (AB122) in participants with advanced solid malignancies.

cancer chemotherapy
immunosuppressant
prednisone
mammogram
growth factor
  • 160 views
  • 28 Jul, 2021
  • 21 locations
Coping Together: Couple-based Interventions for Cancer

The objective of the proposed study is to evaluate the Couple Communication Skills Training (CCST) intervention in 250 patients with advanced cancer and their spouses/intimate partners. Couples

  • 0 views
  • 22 Jul, 2021
  • 1 location
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV

This phase I trial investigates the side effects of cabozantinib and nivolumab in treating patients with cancer that has spread to other places in the body (advanced) and who are undergoing treatment for human immunodeficiency virus (HIV). Cabozantinib may stop the growth of tumor cells by blocking some of the …

antiretroviral
cancer
antiretroviral therapy
immunodeficiency
HIV Vaccine
  • 0 views
  • 31 Jul, 2021
  • 2 locations
Study in Patients With Advanced Cancers Associated With Expression of DLL3 Who Have Failed Standard Available Therapy

An open-label, Phase 1/2 study of HPN328 as monotherapy to assess the safety, tolerability and PK in patients with advanced cancers associated with expression of DLL3.

cancer chemotherapy
platelet count
neutrophil count
platinum-based chemotherapy
delta-like protein 3
  • 0 views
  • 24 Jul, 2021
  • 7 locations
Study of CTX-471 in Patients Post PD-1/PD-L1 Inhibitors in Metastatic or Locally Advanced Malignancies

This is a Phase 1, open-label, first-in-human study of CTX-471 monotherapy in patients with metastatic or locally advanced malignancies that have progressed while receiving an approved PD-1 or

renal function
metastasis
screening procedures
platelet count
pd-l1
  • 26 views
  • 01 Aug, 2021
  • 6 locations