Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 122 clinical trials
Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies

This study is a Phase Ib, multi-center, open-label study of TNO155 in combination with spartalizumab or ribociclib with a dose escalation part followed by a dose expansion part in adult subjects with advanced solid tumors. These two treatment arms will enroll subjects in parallel to characterize the safety, tolerability, PK, …

solid tumors
cancer
tno155
cancer chemotherapy
ki-ras
  • 5 views
  • 01 Aug, 2021
  • 8 locations
A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations

The purpose of this study is to evaluate the efficacy of erdafitinib in terms of overall response rate (ORR) in participants with advanced solid tumors with fibroblast growth factor receptor (FGFR) mutations and gene fusions.

measurable disease
solid tumour
cancer
growth factor
  • 33 views
  • 26 Jul, 2021
  • 266 locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

cancer treatment
mammogram
HIV Infection
ipatasertib
taselisib
  • 6087 views
  • 01 Aug, 2021
  • 1021 locations
Study to Evaluate CCS1477 in Advanced Tumours

A Phase 1/2a study to assess the safety, tolerability, PK and biological activity of CCS1477 in patients with metastatic castration resistant prostate cancer (mCRPC) or advanced solid tumours.

androgen
bone scan
enzalutamide
bone lesions
progressive disease
  • 34 views
  • 18 Jul, 2021
  • 9 locations
A Trial of ZL-1201 in Subjects With Advanced Cancer

First in Human, Phase I Trial of Anti-CD47 Antibody ZL-1201 in Subjects with Advanced Cancer

  • 0 views
  • 01 Aug, 2021
  • 5 locations
Oral STAT3 Inhibitor TTI-101 in Patients With Advanced Cancers

Many patients have cancers that have increased activity of a protein called STAT3 that contributes critically to the development and growth of their cancer. Despite our knowledge of STAT3's importance to cancer, scientists and doctors have not developed a drug that targets it and that patients can take to treat …

measurable disease
cancer
kidney function test
neutrophil count
solid neoplasm
  • 167 views
  • 01 Aug, 2021
  • 1 location
9-ING-41 in Patients With Advanced Cancers

GSK-3 is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3 inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.

solid tumors
MRI
lipase
mammogram
liver metastasis
  • 542 views
  • 31 Jul, 2021
  • 16 locations
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer

This study will examine the safety of giving the experimental drug, resiniferatoxin (RTX), to treat severe pain in patients with advanced cancer. RTX is a chemical extracted from a cactus-like

vasectomy
weakness
cancer
administration of blood products
neurological examinations
  • 326 views
  • 01 Aug, 2021
  • 1 location
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer

This study is an open-label, Phase 1/2, multicenter study to evaluate the safety, tolerability, PK, and PD profiles of a novel Fc-engineered IgG1 anti-CTLA-4 human monoclonal antibody (AGEN1181) monotherapy and in combination with a human monoclonal IgG4 antibody (AGEN2034), and to assess the maximum tolerated dose (MTD) in subjects with …

measurable disease
anticoagulant therapy
squamous cell carcinoma
carcinoma
bladder cancer
  • 3 views
  • 25 Jul, 2021
  • 8 locations
Study of CPI-200 in Patients With Advanced Tumors

This is a prospective, open-label, single arm, non-randomized study of CPI-200 in patients with advanced tumors. CPI-200 is administered via intravenous infusion using an accelerated titration

renal function
metastasis
  • 0 views
  • 01 Aug, 2021
  • 1 location