Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 112 clinical trials
Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well larotrectinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with NTRK fusions that have spread to other places in the body and have come back or do not respond to treatment. Larotrectinib may stop the growth of …

glomerular filtration rate
anti-cancer agents
cancer
rxdx-101
iobenguane
  • 351 views
  • 28 Jul, 2021
  • 84 locations
Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well vemurafenib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with BRAF V600 mutations that have spread to other places in the body (advanced) and have come back (recurrent) or do not respond to treatment (refractory). Vemurafenib may …

anti-cancer agents
cancer
iobenguane
cancer chemotherapy
encorafenib
  • 236 views
  • 28 Jul, 2021
  • 76 locations
Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well erdafitinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have spread to other places in the body and have come back or do not respond to treatment with FGFR mutations. Erdafitinib may stop the growth of …

anti-cancer agents
cancer
iobenguane
solid tumor
measurable disease
  • 261 views
  • 28 Jul, 2021
  • 82 locations
Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well olaparib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with defects in deoxyribonucleic acid (DNA) damage repair genes that have spread to other places in the body (advanced) and have come back (relapsed) or do not respond …

anti-cancer agents
cancer
iobenguane
solid tumor
talazoparib
  • 199 views
  • 28 Jul, 2021
  • 75 locations
Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back (recurrent) or do not respond to treatment (refractory) and have spread to other places in the body (advanced). …

glomerular filtration rate
anti-cancer agents
ROS1
cancer
colony stimulating factor
  • 68 views
  • 28 Jul, 2021
  • 77 locations
3D Prediction of Patient-Specific Response

for assessing tissue response to therapy in patients with advanced cancers, including ovarian cancer, high-grade gliomas, and high-grade rare tumors.

cancer of the ovary
cancer
cancer chemotherapy
cytotoxic chemotherapy
  • 205 views
  • 19 Jul, 2021
  • 9 locations
Cancer Risk in Carriers of the Gene for Xeroderma Pigmentosum

This study will determine if family members of patients with xeroderma pigmentosum (XP) have various abnormalities, including: skin abnormalities; nervous system abnormalities, such as hearing problems; skin, eye, or internal cancers, or other changes. XP is a rare inherited disease that involves an inability to repair damage to cell DNA …

skin lesion
x-rays
cancer
skin cancer
  • 5 views
  • 28 Jul, 2021
  • 1 location
International Registry for Men With Advanced Prostate Cancer (IRONMAN)

Our intent is to establish the International Registry to Improve Outcomes in Men with Advanced Prostate Cancer (IRONMAN) as a prospective, international cohort of minimum 5,000 men with advanced

castration-resistant prostate cancer
  • 677 views
  • 16 Jul, 2021
  • 200 locations
Project: Every Child for Younger Patients With Cancer

This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.

cancer
desmoid tumors
bone marrow procedure
nephroblastoma
carcinoma
  • 366 views
  • 28 Jul, 2021
  • 124 locations
Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

Background Recent advances in cancer research have led to new therapies to treat the disease. It is important to continue these advances and discover new ones. To do that, researchers need tissue samples from solid tumors. This study will collect such samples from people already scheduled to have a procedure …

solid tumor
white blood cell count
solid tumour
cancer
  • 18 views
  • 26 Jul, 2021
  • 1 location