Advanced Malignancies Clinical Trials

A listing of Advanced Malignancies medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 13 clinical trials
A Clinical Study Preliminary Efficacy of LM-061 Tablet in Subjects With Advanced Tumours

This is a phase I/II, open-label, dose escalation and dose extension study to evaluate the safety, tolerability, PK, and preliminary efficacy of LM-061 in subjects with advanced tumors.

  • 0 views
  • 07 Jun, 2021
  • 1 location
A Study to Evaluate the Tolerance and Pharmacokinetics of TQB2858 Injection in Subjects With Terminal Malignant Tumors

This study is a phase I study to evaluate the safety and tolerability of TQB2858 injection in patients with advanced malignancy.

  • 0 views
  • 14 Jun, 2021
  • 1 location
Safety and Oversight of the Individually Tailored Treatment Approach: A Novel Pilot Study

This study is looking at outcomes in people with advanced cancers who have exhausted standard treatment options and are accessing off indication or unregistered drugs or combinations of drugs

treatment regimen
platelet count
primary cancer
bone marrow procedure
trametinib
  • 0 views
  • 18 Jun, 2021
  • 1 location
Metabolic Therapy Program In Conjunction With Standard Treatment For Glioblastoma Multiforme

metabolic therapy program (MTP) utilizing fasting and ketogenic diets is feasible and safe in people with advanced cancer, and may provide a therapeutic benefit. We aim to determine whether using an MTP

cancer
dexamethasone
  • 0 views
  • 10 Jun, 2021
  • 1 location
The Efficacy and Safety of TACE Lenvatinib and Camrelizumab in the Treatment of BCLC Stage B/C Hepatocellular Carcinoma: a Single-arm Single-center Open-label Study

This study is a single-center, single-arm, open-label prospective clinical trial. By recording the disease-free progression (PFS), overall survival (OS) and tumor treatment response of the included patients, it is planned to evaluate TACE, lenvatinib and carrelizumab in the treatment of BCLC B/C hepatocytes Survival benefits of cancer patients; at the …

TACE
metastasis
platelet count
cancer
liver metastasis
  • 0 views
  • 09 Jun, 2021
  • 1 location
ARX517 in Subjects With Advanced Solid Tumor

A Phase 1, Multicenter, Open-label, Dose-escalation, and Dose expansion Study to Evaluate the Safety, Pharmacokinetics, and Anti-tumor Activity of ARX517 in Subjects with Advanced Solid Tumor Who Failed Prior Standard Therapies

  • 0 views
  • 16 Jun, 2021
  • 1 location
APG-115 in Combination With PD-1 Inhibitor in Patients With Advanced Liposarcoma or Advanced Solid Tumors

Part 1 is a phase Ib standard "3 + 3" design, will be employed to determine the MTD of APG-115 by assessing the DLT of APG-115 in combination with PD-1 inhibitor(toripalimab) in advanced solid tumors. Part 2 is a Simon two-stage phase II study design. At RP2D of APG-115 in …

liposarcoma
growth factor
measurable disease
  • 0 views
  • 18 Jun, 2021
  • 1 location
Lurbinectedin With Berzosertib an ATR Kinase Inhibitor in Small Cell Cancers and High-Grade Neuroendocrine Cancers

Background Small cell lung cancer (SCLC) and high-grade neuroendocrine cancers (HGNEC) are aggressive neuroendocrine cancers. At first, SCLC and HGNEC respond to chemotherapy. But then they relapse quickly and become resistant to treatment. Researchers want to see if a combination of drugs can help. Objective To see if the combination …

cancer chemotherapy
kinase inhibitor
lurbinectedin
ATR
measurable disease
  • 0 views
  • 10 Jun, 2021
  • 1 location
A Study of BTX-A51 in People With Advanced Solid Tumor or Non-Hodgkin Lymphoma

This is a multicenter, open label, nonrandomized, sequential dose escalation/cohort expansion, multiple dose study designed to evaluate the safety, toxicity, and PK as well as preliminary efficacy of BTX-A51 in subjects with advanced solid tumors and NHL. The study will be done in two phases, described below. Phase 1a (Dose …

solid tumor
  • 0 views
  • 18 Jun, 2021
  • 2 locations
Safety of Combining Irinotecan With 5-FU Leucovorin/Folinic Acid Oxaliplatin and Docetaxel Chemotherapies

The purpose of the proposed study is to establish the safety of combining irinotecan chemotherapy with 5-FU, leucovorin/folinic acid, oxaliplatin, and docetaxel (abbreviated as the I-FLOAT study of gFOLFOXIRITAX) chemotherapies (leucovorin/folinic acid is a vitamin to make 5-FU work well).

adenocarcinoma
metastasis
oxaliplatin
liver metastasis
primary tumor
  • 0 views
  • 17 Jun, 2021
  • 1 location