Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders Clinical Trials

A listing of Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 12 clinical trials
A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum Disorder

The objective of this study is to evaluate the safety and efficacy of eculizumab in pediatric participants (aged 2 to < 18 years) with relapsing neuromyelitis optica spectrum disorder (NMOSD).

immunosuppressive therapy
human chorionic gonadotropin
aquaporin 4
immunosuppressive agents
  • 05 May, 2022
  • 17 locations
In Vitro Study of the Biological and Immunological Activity of Imotopes® Candidates on Blood Cells of Patients With Stabilized NMO

This is a fundamental, prospective, multi-centres, interventional non-comparative study without the administration of a study product to patients. A phase 0 study is particularly well adapted to early exploration of potential targeted treatments - i.e. treatments whose efficacy can only be hoped for in patients presenting specific biological characteristics in …

aquaporin 4
  • 18 Apr, 2022
  • 2 locations
A Phase III Study of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Neuromyelitis Optica Spectrum Disorders

The purpose of this study is to initially observe the safety and effectivity of RC18 in Participants with Neuromyelitis Optica Spectrum Disorders.

aquaporin 4
  • 21 Mar, 2022
  • 1 location
Optic Neuritis Differential Diagnosis Study (ONDDS)

Background: Optic neuritis is a frequent cause of vision loss encountered by ophthalmologists in the Caribbean. The diagnosis is made on clinical grounds. Optic neuritis can occur either in an isolated manner or, most often, as the first symptom of multiple sclerosis (MS) or neuromyelitisoptica (NMO). These 2 demyelinating disorders …

demyelinating disorder
vision loss
demyelinating disorders
optic neuritis
bilateral optic neuritis
  • 10 Mar, 2022
  • 1 location
Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Idiopathic Inflammatory Diseases of the Nervous System (CARTinNS)

Antibody-mediated idiopathic inflammatory diseases of the nervous system (also known as autoimmune diseases of the nervous system) are autoimmune diseases in which autoimmune cells and immune molecules attack the nervous system as the main pathogenic mechanism. In the immune response, pathogenic antibodies acting on autoantigens of the nervous system are …

neutrophil count
absolute neutrophil count
cell counts
  • 08 Jul, 2022
  • 1 location
Autologous Peripheral Blood Stem Cell Transplant for Neurologic Autoimmune Diseases

This phase II trial studies the side effects and how well carmustine, etoposide, cytarabine and melphalan together with antithymocyte globulin before a peripheral blood stem cell transplant works in treating patients with autoimmune neurologic disease that did not respond to previous therapy. In autoimmune neurological diseases, the patient's own immune …

antithymocyte globulin
cerebellar degeneration
encephalitis autoimmune
  • 11 Jul, 2022
  • 3 locations
Clinical and Imaging Patterns of Neuroinflammation Diseases in China (CLUE)

CLUE is a prospective study to determine structural and functional changes of brain and spinal cord, as well as the inflammatory environment in patients with neuroinflammatory and demyelination disease. Subjects will receive new magnetic resonance (MR) technics including double inversion recovery (DIR) imaging diffusion kurtosis imaging (DKI), quantitative susceptibility mapping …

Accepts healthy volunteers
immunomodulation therapy
steroid therapy
  • 04 Oct, 2022
  • 1 location
Pediatric NMOSD Observational Study

This study is being done to develop a database of pediatric patients in order to study the cause, early detection and best treatment for neuromyelitis optica spectrum disorder (NMOSD) in pediatric patients.

early detection
  • 01 Feb, 2022
  • 1 location
The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders

This study seeks to determine the biologic causes of inflammation in patients with Transverse Myelitis (TM) Neuromyelitis Optica Spectrum Disorder (NMOSD) and related conditions. While patients will be treated according to decisions with their treating physician, this study will collect data and samples from patients prospectively to gain a better …

Accepts healthy volunteers
transverse myelitis
neuromyelitis optica
  • 23 May, 2022
  • 1 location
PEDIATRIC SONICS: Pediatric Study of Neuropsychology and Imaging in CNS Demyelinating Syndromes. (SONICS)

Central Nervous System (CNS) demyelinating conditions include multiple sclerosis (MS), Acute Disseminated Encephalomyelitis (ADEM), Neuromyelitis Optica Spectrum Disorder (NMOSD), Optic Neuritis (ON) and Transverse Myelitis (TM). The symptoms of these conditions are quite variable from patient to patient, but can include motor, sensory, visual, gait and cognitive changes. Conventional MRI …

Accepts healthy volunteers
multiple sclerosis
  • 04 Oct, 2022
  • 1 location