Hepatic Porphyria Clinical Trials

A listing of Hepatic Porphyria medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 6 clinical trials
Effect of Oral Cimetidine in the Protoporphyrias

Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) result from genetic defects of heme biosynthesis that cause life-long, painful cutaneous sensitivity to light. The objective of this study is to determine the efficacy and safety of oral cimetidine administration for treatment of the protoporphyrias. Efficacy will be based on protoporphyrin levels, …

  • 07 Jul, 2022
  • 1 location
Panhematin for Prevention of Acute Attacks of Porphyria

The purpose of this study is to determine if Panhematin is safe and effective for prevention of acute attacks of porphyria. The study aims to provide high quality evidence for the use on hemin for prevention of acute attacks of porphyria. High quality studies have not been done previously for …

  • 02 Dec, 2021
  • 1 location
ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP) (ELEVATE)

This global patient registry is being conducted to characterize the natural history and real-world clinical management of patients with AHP, and to further characterize the real-world safety and effectiveness of givosiran and other approved AHP therapies.

  • 22 Jul, 2022
  • 21 locations
Longitudinal Study of the Porphyrias

The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the human porphyrias including the natural history, morbidity, pregnancy outcomes, and mortality in people with these disorders.

  • 21 Mar, 2022
  • 11 locations
PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis

The investigators' objective is to compare the risk of mortality and/or treatment failure in children admitted to the PICU with sepsis and managed by PCT guided therapy for stopping of antibiotics ('study' group) with those managed with 'standard practices' based on the evidence based guidelines ('control' group). Children with suspected …

systemic inflammatory response syndrome
inflammatory response
antibiotic therapy
  • 19 Jul, 2021
  • 1 location
Evaluating the Prevalence of Acute Hepatic Porphyria in Postural Tachycardia Syndrome

> The acute hepatic porphyrias(AHP)are among the diseases that present with autonomic cardiovascular(tachycardia)and neurovisceral symptoms (abdominal pain) among others; they present with acute

  • 16 May, 2022
  • 1 location