Dravet Syndrome Clinical Trials

A listing of Dravet Syndrome medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 18 clinical trials
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Expanded Access with Adjunctive Ganaxolone (GNX) Treatment in Children and Young Adults with Cyclin-dependent Kinase-like 5 (CDKL5) deficiency disorder (CDD)

The primary objective is to provide GNX to patients ≥ 2 years with CDD-related seizures who are refractory to, or intolerant of, standard therapy.

  • 0 views
  • 30 Jun, 2021
  • 2 locations
A Phase 2 Prospective Interventional Open-Label Multi-Site Extension Study to Assess the Long-Term Safety and Tolerability of TAK-935 (OV935) as Adjunctive Therapy in Patients With Rare Epilepsy

The main purpose of this study is to investigate the long-term safety and tolerability of TAK-935/OV935 as an adjunctive therapy in patients with rare epilepsies.

  • 107 views
  • 24 Jul, 2021
  • 64 locations
EPX-100 (Clemizole Hydrochloride) as Add-on Therapy to Control Convulsive Seizures in Patients With Dravet Syndrome

The purpose of this study is to compare the efficacy of EPX-100 against placebo as adjunctive therapy in 60 patients with Dravet Syndrome.

antiepileptic
epilepsy
tonic
seizure
tonic clonic convulsion
  • 22 views
  • 22 Sep, 2021
  • 4 locations
An Open-Label Study to Investigate the Safety of Single and Multiple Ascending Doses in Children and Adolescents With Dravet Syndrome

Stoke Therapeutics is evaluating the safety and tolerability of single and multiple ascending doses of STK-001 in patients with Dravet syndrome. Change in seizure frequency, overall clinical

epilepsy
scn1a gene
tonic
fever
ketogenic diet
  • 64 views
  • 10 May, 2021
  • 18 locations
  • 0 views
  • 06 Apr, 2021
  • 28 locations
Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution

This study will monitor for potential chronic liver injury and liver fibrosis, in participants treated with cannabidiol oral solution.

  • 0 views
  • 24 Sep, 2021
  • 17 locations
Efficacy of Epidiolex in Patients With Electrical Status Epilepticus of Sleep (ESES).

This study aims to assess the efficacy of Epidiolex in patients with ESES. ESES is characterized by sleep potentiated spikes with a spike index greater than 85% (conventional definition) and 50% (new definition)1. Several drugs including: steroids, intravenous Gama globulin, Clobazam, other benzodiazepines, Valproic acid, and other anti-epileptic drugs have …

  • 0 views
  • 23 Jul, 2021
  • 1 location
Phenylbutyrate for STXBP1 Encephalopathy and SLC6A1 Neurodevelopmental Disorder

STXBP1 Encephalopathy is a severe disease that can cause seizures and developmental delays in infants and children. It occurs when one copy of the STXBP1 gene has a mutation that causes the gene's protein to not work properly. SLC6A1 neurodevelopmental disorder is characterized by developmental delay and often epilepsy. It …

  • 0 views
  • 26 Aug, 2021
  • 2 locations
CBD Oil for Reducing Emotional Impact of COVID-19

The overarching objective of the proposed project is to test the relative clinical efficacy of CBD isolate, full-spectrum CBD oil, and placebo in in reducing COVID-Induced stress, anxiety, depression, anger, and sleep disturbance.

  • 0 views
  • 05 Mar, 2021
  • 1 location
Use of CBD Oil in the Treatment of Posttraumatic Stress Disorder

The overarching objective of the proposed project is to test the clinical efficacy of CBD in the treatment of post-traumatic stress disorder using a rigorous double-blind randomized clinical trial methodology. Participants (n=150) meeting full DSM-5 criteria for post-traumatic stress disorder (PTSD) will be randomized to one of 3 treatment arms: …

psychiatric disorder
psychotherapy
  • 523 views
  • 12 Aug, 2021
  • 1 location