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Liver Disease Clinical Trials

A listing of Liver Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (22) clinical trials

PLX3397 Plus Sirolimus in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors

Malignant peripheral nerve sheath tumors (MPNSTs) represent up to 10% of adult soft tissue sarcomas. Due to its rarity, few MPNST-specific prospective trials exist, and treatments are largely based on extrapolation from results from other sarcoma subtypes. Since the molecular pathways driving pathogenesis within sarcoma subtypes are distinct, these treatment ...

Phase

Study of Pembrolizumab and Radiotherapy in Liver Cancer

This is a phase 2 study whose purpose is to assess the efficacy of the combination of pembrolizumab and stereotactic body radiotherapy (SBRT) in patients with advanced hepatocellular carcinoma (HCC) who have experienced disease progression after treatment with sorafenib.

Phase

Nottingham Community Liver Biomarkers Cohort

Objectives To establish a community based cohort with risk factors for liver disease and stratification for liver disease severity using non-invasive biomarkers. To establish the incidence of liver and cardiovascular morbidity and mortality in a community cohort. To explore the quantitative and qualitative indicators to potential alterations in patient lifestyle ...

Phase N/A

Tumour and HEalthy Tissues DOse-response and Radiosensitivity Assay

For that purpose, this project is composed of 3 stages: A Calibration stage that will allow to evaluate the correlation between the clinical tumor response parameters (i.e. TV/AP features) and the radiobiological parameters issued from the A/MS bioassays in order to develop a mathematic model defining the UTCR parameter A ...

Phase N/A

Immune Cell Dysfunction in Severe Alcoholic Hepatitis

Through bio-sampling this study investigates the relationship between the frequency and function of the cells of a patients immune system and how these change and impact on the outcome of alcoholic hepatitis. The investigators will examine the role of different cells of the immune system and how they may determine ...

Phase N/A

SMS-based Lifestyle Intervention for Patients With Liver Cirrhosis With Previous Hepathic Encephalopathy

Physical exercise and other interventions focused on lifestyle factors have not only the potential to increase physical functioning and capacity, but also to affect fundamental aspects of disease, increase quality of life, and may even increase survival in patients with liver cirrhosis. Instruction and advice about a healthy lifestyle and ...

Phase N/A

Liver Fibrosis in Sickle Cell Disease

Liver biopsy is the gold standard to examine the liver for iron deposits and histology. However, liver biopsy is invasive and involves a risk of bleeding and pain. Biopsy may also miss significant pathology if the small biopsy specimen is taken from an uninvolved part of the liver. Non-invasive techniques ...

Phase N/A

Identification of New Serum Diagnostic Markers of Hepatocellular Carcinoma

Liver cancer is a deadly cancer that is typically hard to diagnose and treat. The currently used blood marker for the clinical diagnosis of liver cancer is alpha-feto protein (AFP), which misses 40-60% of patients with liver cancer because it lacks sufficient specificity and sensitivity. The purpose of this study ...

Phase N/A

Genetic and Telomere Characteristics of High of Grade Soft Tissue Sarcomas

Aims The investigators plan a 2 year pilot observational study to: Identify and quantify circulating cell-fee DNA (cfDNA) in cases of Soft Tissue Sarcoma (STS) Investigate Telomere Maintenance Mechanisms (TMM) in STSs. Use TMM associated genetic mutations to identify and quantify tumour-derived cfDNA in STSs at time of tumour resection ...

Phase N/A

Patients are needed to participate in a clinical research study for the treatment of Liver Disease Chronic, Hepatitis B Virus

Intervention: Serological markers of HBV will be assessed prospectively in consecutive non-cirrhotic liver disease or cirrhotic patients. Seronegative patients willing to participate will sign a written informed consent and will receive four doses of 20 g Fendrix at 0,1, 2 and 6 months. Antibodies against HBV superficial antigen (anti-HBs) will ...

Phase N/A