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Opioid Use Disorder Clinical Trials

A listing of Opioid Use Disorder medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (89) clinical trials

PRimary Care Opioid Use Disorders Treatment (PROUD) Trial

Effective treatment for opioid use disorders (OUDs) requires medications. Two medications for treating OUDsbuprenorphine and injectable naltrexonecan be prescribed in primary care (PC). However, despite the current opioid epidemic and expert recommendations that OUDs should be treated in PC, most PC clinics do not offer treatment for OUDs. This reflects ...

Phase N/A

Tapering of Long-term Opioid Therapy in Chronic Pain Population. RCT With 12 Months Follow up

Chronic non-cancer pain is a major problem in society and a common cause to seek health care. The suffering is complex as it, besides pain, often includes psychological symptoms and may decrease the ability to participate in work life. Pharmacological treatments have limited possibilities to ease suffering. Opioids used in ...

Phase N/A

Developing rTMS Treatment Strategies for Pain in Opiate Dependence

Chronic use of opiates is a rapidly escalating crisis in the United States, with over 4.3 million Americans dependent on opiate analgesic, an escalating rate of opiate overdose deaths, and a resurgence of intravenous heroin use leading to total societal cost exceeding $55 billion. The struggle to break the addiction ...

Phase N/A

The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence

Methadone maintenance therapy (MMT) has shown clear efficacy for relieving opioid withdrawal symptoms and reducing the morbidity and mortality of opioid dependence. A notable phenomenon associated with MMT is increased food intake, enhanced sweet preferences, and weight gain. The underlying neural mechanisms for opioid-related overconsumption are not well understood but ...

Phase N/A

Improving Office Based Treatment of Opioid Use Disorder With Technology

The misuse and abuse of opioids is a serious public health problem. SAMHSA estimates that more than 12 million Americans misuse prescription opioids for nonmedical purposes annually. The costs of this problem are substantial, both to individuals and society: total costs of prescription opioid misuse, abuse, and overdose to the ...

Phase N/A

Buspirone for Opioid Tapering

Buspirone (Buspar) has shown initial efficacy in reducing symptoms of opioid withdrawal in animal studies and in human patients undergoing a methadone taper. Buspirone may have pharmacologic activity in specific neurotransmitter systems that preclinical evidence suggests may be implicated in the manifestation of opioid withdrawal symptoms. Administration of buspirone during ...

Phase

Minimal Opioid Use After Total Hip Replacement (THR)

Total hip arthroplasty can be associated with significant postoperative pain. Side effects of pain management may impair participation in physical therapy and slow readiness for discharge from the hospital. In a previous study done by the investigators' group, epidural patient controlled analgesia (EPCA) with a hydromorphone containing solution appeared to ...

Phase

Opioid Free Anesthesia in Bariatric Surgery

Since optimal analgesia for the obese patients undergoing bariatric surgeries has always been challenging, and knowing the comorbidities and physiological changes in this population, use of opioid-sparing agents during anesthesia has attracted substantial research.the use of opioids in the perioperative period in obese patients is associated with an increased risk ...

Phase N/A

Houston Emergency Opioid Engagement System

The purpose of this study is understand how many opioid emergencies are in Houston, to develop an opioid system of care in Houston, and to evaluate if patients who receive both medication assisted treatment (MAT) in the hospital and follow up by emergency medical services (EMS) post-discharge will enroll and ...

Phase

Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients

The two participating institutions, WCMC (Weill Cornell Medical College) and IFH (Institute for Family Health), intend to redesign the e-prescribing interface to create a minor "nudge" to encourage prescribers to prescribe the minimum dose set by the 2016 CDC guideline for opioid-naive patients in 2018. The change to the e-prescribing ...

Phase N/A