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Opioid Use Disorder Clinical Trials

A listing of Opioid Use Disorder medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (74) clinical trials

A Strategy to Improve Success of Treatment Discontinuation in Buprenorphine Responders

This study is an open--label randomized outpatient trial to evaluate feasibility and efficacy of rapid buprenorphine (BUP) discontinuation followed by brief course of treatment with long--acting naltrexone (XR--NTX) and to compare it to the standard method of gradual BUP taper.Individuals with opioid use disorder (OUD) (N=60) who have successfully completed …


Opioid Use Disorder in the Emergency Department: CTN 0069

The study uses a Hybrid Type 3 Effectiveness-Implementation framework and a modified stepped wedge design. The study will be conducted at four EDs with a high prevalence of patients with untreated opioid use disorder (OUD). The four sites will receive the same sequence of evaluations and interventions: the baseline evaluation …

Phase N/A

Rapid Initiation of Drug Treatment Engagement

Study Objectives Aim 1: To evaluate the impact of the mobile, transitional MAT intervention on its ability to engage participants in targeted, existing MAT treatment slots at 1- and 6-month post-enrollment. Aim 2: To evaluate the impact of the mobile intervention on subsequent drug use and overdoses at 6-month post-enrollment. …


SafetyNet Program for Opioid Use Disorder (OUD)

Scientific premise for proposed project. Buprenorphine/naloxone-based (BUP) treatment for opioid use disorder (OUD). It is known that medication-assisted therapy (MAT) of opioid use disorder (OUD) with buprenorphine/naloxone (BUP) is associated with decreased risk of opioid overdose, improved engagement in treatment at 30 days, and less self-reported opioid use compared with …

Phase N/A

Emergency Department-Initiated Buprenorphine Validation Network Trial

The study will be comprised of four components as outlined below: Site implementation component: In this component, the investigators will use previously developed implementation facilitation strategies and resources to train ED providers and staff at approximately 30 diverse EDs in treatment initiation with SL-BUP and XR-BUP and develop ED buprenorphine …


Remote Observed Dosing of Suboxone to Improve Clinical Practice

This is a 15-week, outpatient study of remote observed dosing to improve suboxone compliance in opiate dependent subjects.The main purpose of this study is to see if watching patients take their medication will improve treatment of opiate dependence by prompting patients to take all prescribed doses of Suboxone. Suboxone is …


Cannabidiol Use to Reduce Cravings in Individuals With Opioid Use Disorder on Buprenorphine

Studies have indicated that medication treatment for opioid use disorder (OUD) with buprenorphine, methadone, or extended-release naltrexone reduces the risk for overdose by 70%. However, treatment dropout rates remain unacceptably high, with approximately 50% of patients discontinuing treatment 6 months after initiation. There is a substantial body of research indicating …


Outcomes Mandate National Integration With Cannabis as Medicine

Medical cannabis has been legal in parts of the USA since 1996, with the stated intention of reducing pain (both acute and chronic) as well as for treatment of multiple other conditions. The original implementation of medical cannabis in the USA was implemented in California as a compassionate measure to …


Mindfulness-Based Relapse Prevention for Opioid Use Disorders

A randomized controlled trial will examine mindfulness-based relapse prevention (MBRP) program outcomes for 240 individuals who have completed treatment for opioid use disorders. MBRP is a group aftercare program that integrates mindfulness skills training with cognitive-behavioral relapse prevention strategies. Primary outcomes will include frequency of opioid use, craving, withdrawal, and …

Phase N/A

A Study to Assess the Safety Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants

Participants will be screened for up to 28 days prior to first investigational product administration. Eligible participants will be admitted to the clinical unit on day -1 and will be residential for a single period of 17 days/16 nights. Participants will be discharged from the clinical unit on day 16 …