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Opioid Use Disorder Clinical Trials

A listing of Opioid Use Disorder medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (7) clinical trials

A Study to Assess the Safety Tolerability and Pharmacokinetics of Multiple Doses of ASP8062 With a Single Dose of Morphine in Recreational Opioid Using Participants

Participants will be screened for up to 28 days prior to first investigational product administration. Eligible participants will be admitted to the clinical unit on day -1 and will be residential for a single period of 17 days/16 nights. Participants will be discharged from the clinical unit on day 16 …

Phase

A Study to Assess the Effect of a Single Dose of ASP8062 on the Multiple Dose Safety Tolerability and Pharmacokinetics of Buprenorphine/Naloxone in Participants With Opioid Use Disorder

Participants will be screened for up to 28 days prior to first investigational product (IP) administration. Eligible participants will be admitted to the clinical unit on day -1 and will be residential for a single period of 27 days/26 nights. Participants will be discharged from the clinical unit after completion …

Phase

The Effect of Chronic Pain on Delay Discounting in Methadone Patients

This is an outpatient Phase 1 clinical trial investigating the effect of naloxone precipitated withdrawal on delay discounting. Eligible participants will undergo two experimental sessions presented in random order. One session will involve the measurement of delay discounting 30 minutes after double-blind intramuscular (IM) administration of placebo (normal saline) and …

Phase

INDV-2000 First in Human

This study will be a single ascending dose (SAD) study conducted to identify the maximum tolerated dose (MTD). After completion of the SAD portion of the study and acceptable safety evaluation, a food-interaction, single-dose study under fed and fasted conditions will be conducted.

Phase

Acute Pain Management in Patients on Opioid Replacement Therapy

Eligible participants will have 8 sessions where they will receive two IM injections.The dose of ketamine will be manipulated (0 mg/kg to 0.4 mg/kg) across sessions. The dose of hydromorphone will either be 0 mg or 8 mg. Therefore, participants will be exposed to ascending doses of ketamine with and …

Phase

Oxytocin Stress Craving Opioid Use Disorder

The goal of this research is to evaluate whether oxytocin, a hormone with anti-stress properties, dampens the effects of stress and opioid-associated cues on opioid craving and thus may be an effective adjunctive treatment for OUD. The central hypothesis of this research is that oxytocin will reduce stress-induced opioid craving …

Phase

Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid Abstinence

If participants meet all the criteria, their involvement in the study (Phases 1 and 2 described below) will last for 10-13 weeks. Participants will be asked to stay at the research site for a minimum of 2 nights on 4 separate weeks and will have 22 office visits During that …

Phase