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Opioid Use Disorder Clinical Trials

A listing of Opioid Use Disorder medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (110) clinical trials

Facilitating Rapid Naltrexone Initiation

This study combines a nonopioid detoxification; a naltrexone titration schedule that allows for pushing the dose rapidly while monitoring closely to ensure tolerability; and infusions integrated into the treatment in such a way as to potentially ameliorate spontaneous and precipitated withdrawal. The first part of the treatment trial involves receiving ...


Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid Abstinence

If participants meet all the criteria, their involvement in the study (Phases 1 and 2 described below) will last for 10-13 weeks. Participants will be asked to stay at the research site for a minimum of 2 nights on 4 separate weeks and will have 22 office visits During that ...


Opioid Dependence Treatment Therapies in Pregnancy

Objective The goal of this proposal is to conduct a pilot study to establish the feasibility and acceptability of a randomized comparative effectiveness clinical trial comparing office-based buprenorphine vs. federally licensed methadone programs for the treatment of opioid dependent pregnant women. Specific Aims: Aim 1: Evaluate the feasibility of conducting ...

Phase N/A

PRimary Care Opioid Use Disorders Treatment (PROUD) Trial

Effective treatment for opioid use disorders (OUDs) requires medications. Two medications for treating OUDsbuprenorphine and injectable naltrexonecan be prescribed in primary care (PC). However, despite the current opioid epidemic and expert recommendations that OUDs should be treated in PC, most PC clinics do not offer treatment for OUDs. This reflects ...

Phase N/A

Tapering of Long-term Opioid Therapy in Chronic Pain Population. RCT With 12 Months Follow up

Chronic non-cancer pain is a major problem in society and a common cause to seek health care. The suffering is complex as it, besides pain, often includes psychological symptoms and may decrease the ability to participate in work life. Pharmacological treatments have limited possibilities to ease suffering. Opioids used in ...

Phase N/A

Opioid Free Anesthesia in Bariatric Surgery

Since optimal analgesia for the obese patients undergoing bariatric surgeries has always been challenging, and knowing the comorbidities and physiological changes in this population, use of opioid-sparing agents during anesthesia has attracted substantial research.the use of opioids in the perioperative period in obese patients is associated with an increased risk ...

Phase N/A

Houston Emergency Opioid Engagement System

The purpose of this study is understand how many opioid emergencies are in Houston, to develop an opioid system of care in Houston, and to evaluate if patients who receive both medication assisted treatment (MAT) in the hospital and follow up by emergency medical services (EMS) post-discharge will enroll and ...


Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients

The two participating institutions, WCMC (Weill Cornell Medical College) and IFH (Institute for Family Health), intend to redesign the e-prescribing interface to create a minor "nudge" to encourage prescribers to prescribe the minimum dose set by the 2016 CDC guideline for opioid-naive patients in 2018. The change to the e-prescribing ...

Phase N/A

Feasibility and Validation of a Standard Phenotyping Assessment Battery

There is profound heterogeneity of subjects in clinical studies of addictions, with patients being diagnosed by the primary substance of use. As a result, utilizing current DSM addictions classification leads to problems with signal detection and hamper the progress of the development of new drugs and treatments for substance use ...

Phase N/A

MAT for Opioid Use Disorders

Medication Assisted Treatment (MAT) of Veterans with Opioid Use Disorder (OUD) decreases mortality and improves treatment follow-up. However, outside of large and/or urban VA medical centers, there are shortages of providers with experience treating OUD and a license to prescribe buprenorphine. This has resulted in decreased access to MAT (buprenorphine/naloxone ...

Phase N/A