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Alcohol Use Disorder Clinical Trials

A listing of Alcohol Use Disorder medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (300) clinical trials

Severe Alcohol-use Disorder: a tDCS and Response Inhibition Training Intervention

Treating Alcohol dependence remains notoriously difficult despite use of several medications, psychotherapeutic and psychosocial interventions. Alcohol dependence is thought to reflect an abnormal interplay between two neural systems: an overly active impulsive one driven by immediate rewards prospects and a weak reflective one, tuned on long-term prospects. The investigators proposes ...

Phase N/A

Randomized Clinical Trial Evaluating BP1.3656 Versus Placebo For Alcohol Use Disorder Treatment

Proof of concept study evaluating in alcohol use disorder, the ability of psychosocial support in combination with BP1.3656 to reduce alcohol consumption. The study will be a multicenter, randomized, double-blind, placebo-controlled phase II trial with parallel groups to evaluate the effectiveness and the safety of BP1.3656.

Phase

Learning and Relapse Risk in Alcohol Dependence (FP2)

This Project will examine 130 detoxified alcohol-dependent patients and 40 age- and gender matched controls. All subjects will be treated with Zooming Joystick Task (ZJT) training to alter a habitual alcohol cue approach bias. The primary aim of this project is to assess which behavioural and neuroimaging alterations (fMRI) associated ...

Phase N/A

Bilateral Prefrontal Modulation in Crack-cocaine Addiction

Before (baseline) and after tDCS or sham-tDCS treatment, subjects will be examined: clinically, regarding craving (obsessive compulsive scale), depressive (Hamilton depression rating scale) and anxiety (Hamilton anxiety rating scale) symptoms and quality of life of the World Health Organization (WHOQOL-BREF); cognitively, regarding frontal (Frontal assessment battery), mental state (mini-mental status ...

Phase

Fecal Microbial Transplant for Alcohol Misuse in Cirrhosis

Randomized, single-blind, placebo-controlled safety, tolerability study with exploratory endpoints and pathophysiological evaluation of the FMT Two groups of outpatients with cirrhosis will be randomized using random sequence generator into no-treatment and FMT groups. Once patients are randomized 1:1 into group 1 (FMT) and group 2 (Placebo), both will be followed ...

Phase

Double Blind Placebo Control Opipramol-Baclofen Treatment for Addiction

The aim of this study is examining the combination of two FDA approved drugs, Opipramol and baclofen, which may increase rehabilitation from psychoactive substances. Previous studies have indicated a connection of sigma-1 receptor to cocaine abuse and raised the possibility that these receptors as mediators of drug craving . However ...

Phase N/A

Computer Adaptation of Screening Brief MET Intervention to Reduce Teen Drinking

The study aims are to: Assess cMET feasibility and acceptability and estimate its effect size on underage drinking. Hypothesis: Among 14- to 20-yr-old primary care patients, those receiving cMET will have lower rates of any alcohol use, days of alcohol use, drinks per drinking day, and days of heavy episodic ...

Phase N/A

Topiramate Augmenting Strategies for the Treatment of Alcohol Use Disorder

This is a pilot study designed to evaluate the safety, tolerability of Topiramate (TPM) + N-Acetyl Cysteine (NAC) in combination versus Topiramate (TPM) + placebo in 16 subjects enrolled in a 12 week, randomized, double-blind, outpatient trial. Each subject will receive randomly one of the drug combinations for 12 weeks ...

Phase N/A

Combating Craving With Contingency Management: Neuroplasticity and Methamphetamine Abuse in South Africa

Methamphetamine addiction (MA) is a global health problem with high prevalence and great social and health costs in the United States and in the Republic of South Africa, and there is a strong need for development and implementation of effective MA treatment approaches. This study will correlate MA-abstinence outcomes from ...

Phase N/A

HCV Group Evaluation and Treatment Uptake (HCV GET-UP) Intervention

The goal of this proposal is to improve HCV (hepatitis C virus) treatment uptake among current and former injection drug users (IDUs) by testing an innovative, primary care based HCV Group Evaluation and Treatment UPtake (HCV GET-UP) intervention. IDUs make up the majority of the 4 million Americans chronically infected ...

Phase N/A