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Alcohol Dependence Clinical Trials

A listing of Alcohol Dependence medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (260) clinical trials

Substance Misuse To Psychosis for Ketamine (SToP-K)

Evidence suggests that repeated or chronic ketamine use, as compared to acute ketamine users, posed a higher clinical risk of developing psychotic disorders, potentially related to the underlying chronic N-methyl-D-aspartate receptor (NMDAR) dysfunction, and a higher risk of suffering from schizophrenia particularly in those genetically susceptible, or genetically predisposed ketamine ...

Phase N/A

Longitudinal Assessment of Functional Connectivity in Treatment Engaged Cocaine Users

Chronic cocaine use is among the most difficult substance-use disorders to treat. High relapse rates are likely due to a combination of factors that involve limbic and executive circuits in the brain, including vulnerability to salient cues and loss of cognitive control . This may be due to elevated functional ...

Phase N/A

Enhancing Adolescent Substance Abuse Treatment

Adolescents with substance use disorders (SUD) are at high risk for significant deleterious outcomes. Although several evidence-based practices for adolescent SUD exist, they yield only small to medium effects that rapidly diminish (30-70% 6-month relapse rates). A promising approach for determining how to enhance treatment is experimental mediation research. In ...

Phase N/A

Brexpiprazole Study

STUDY OBJECTIVES The primary objectives of the study include: examine the effect of brexpiprazole treatment on the number of days of substance use in the past week as measured by the Timeline Follow-Back (TLFB) assessment; examine the effect of brexpiprazole treatment on substance craving using 100-mm visual analogue scale (VAS). ...


Feasibility of Providing Computerized CBT in the Black Church

The investigator will conduct a pilot study evaluating the feasibility and acceptability of providing a computer-based program (CBT4CBT), used for the treatment of substance use disorders, in a church setting. Forty Black adults with a current DSM-5 alcohol or substance use disorder will utilize the 'CBT for CBT' program over ...

Phase N/A

Improving Linkage to Health and Other Services for Veterans Leaving Incarceration

Veterans leaving incarceration (henceforth, "reentry Veterans") are among the most underserved by the VA and thus are an increasingly high priority population. The Bureau of Justice Statistics estimates that 140,000 Veterans are incarcerated in the U.S. at a given time, approximately 80% of whom are eligible for VA benefits. Many ...

Phase N/A

French Validation of the Dual Diagnosis Screening Interview (F_DDSI)

Type of study: Cross-sectional exploratory, non-interventional Research category : research involving the human person, category III Number of centers: 2 French centers in Auvergne region Study Performance The methodology includes 3 phases : Phase 1: translations / back-translation / expert consensus, comes in four stages. The translation of the Spanish ...

Phase N/A

Interventions to Improve the HIV PrEP Cascade Among Methamphetamine Users

Despite increasing knowledge about and use of PrEP nationally, HIV continues to have disproportionate impact among cisgender men and transgender persons who have sex with men and transgender persons (MSM/TG), with methamphetamine (meth)-users being at particularly high risk. Despite apparent high levels of PrEP knowledge and exceptional insurance and medication ...

Phase N/A

Adapting Alcohol Behavioral Couple Therapy for Service Members in Post-Deployment

The study staff will screen potential participants over the phone, and arrange Baseline (BL) research interviews for appropriate couples. The couple will meet with the program interviewer for approximately 2 hours. After the BL interview, couples will be scheduled to attend therapy sessions. Couples will complete brief within treatment self-report ...

Phase N/A

Personal Values and Mandated Students

High volume drinking and related adverse consequences pose significant health concerns at US colleges and universities; drinking behavior often leads to students being sanctioned for violations of campus alcohol policy. Given the widespread use of mandated alcohol interventions for these students, optimizing their initial effects and their duration could substantially ...

Phase N/A