Sjogren Larsson Syndrome

Sjögren-Larsson Syndrome is a rare genetic disorder characterized by the triad of ichthyosis, intellectual disability, and spasticity. It is caused by mutations in the ALDH3A2 gene, which encodes for an enzyme involved in the breakdown of long-chain fatty alcohols. There is currently no cure for Sjögren-Larsson Syndrome, and treatment is mainly supportive.