Familial Hypercholesterolemia Clinical Trials

A listing of Familial Hypercholesterolemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 50 clinical trials
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CASCADE FH Registry: Cascade Screening for Awareness and Detection of Familial Hypercholesterolemia

CASCADE FH Registry: Cascade Screening for Awareness and Detection of Familial Hypercholesterolemia

  • 23 Nov, 2020
  • 1 location
Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH)

This is a single arm, open label, multi centre phase III study to evaluate the efficacy and long term safety of lomitapide in paediatric patients with HoFH receiving stable LLT (including LA, when applicable) comprising of the following phases: Screening Period (starting at Week 12, i.e. ≤12 weeks prior to …

  • 26 Apr, 2022
  • 11 locations
Phase 2 Study to Evaluate the Safety and Efficacy of ARO-ANG3 in Subjects With Homozygous Familial Hypercholesterolemia (HOFH) (Gateway)

Participants with documented homozygous familial hypercholesterolemia (HoFH) who have provided informed consent will receive 2 open-label doses of ARO-ANG3 and be evaluated for safety and

  • 18 Oct, 2022
  • 7 locations
A Phase I/Ib, Open-label, Multi-center Study of DFF332 as a Single Agent and in Combination With Everolimus or IO Agents in Patients With Advanced/Relapsed ccRCC and Other Malignancies With HIF2α Stabilizing Mutations

This is first in human study of DFF332, a small molecule that targets a protein called HIF2α. By acting on HIF2α, DFF332 may be able to stop the growth of certain types of cancer. DFF332 will be tested at different doses as single agent and in combination with Everolimus (RAD001, …

clear cell renal cell carcinoma
mtor inhibitor
  • 24 Oct, 2022
  • 10 locations
Evaluation of Asdzáán Be'eená Teen Pregnancy and Substance Use Prevention Program for Native American Youth and Their Caregiver

The objective of this research study is to evaluate a culturally grounded program among American Indian (AI) female adolescents and their female caregivers. Specifically, investigators aim to evaluate the impact of "Asdzaan Be'eena'" or Female Pathways in English (henceforth referred to as AB) on risk and protective factors for early …

Accepts healthy volunteers
  • 17 Oct, 2022
  • 2 locations
Cascade Genetic Testing of Familial Hypercholesterolemia (CATCH)

Familial hypercholesterolemia (FH) is a frequent genetic disorder (1/200) associated with an increased risk of early-onset myocardial infarction. To improve detection and treatment of patient

genetic disorder
cardiovascular disease
genetic analysis
myocardial infarction
  • 03 Jun, 2022
  • 1 location
A Study to Evaluate the Efficacy and Safety of JS002 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH).

heterozygous familial hypercholesterolemia (HeFH). Objective To evaluate the efficacy and safety of JS002 150 mg (Q2W) and 450 mg (Q4W) subcutaneous injection (SC).

  • 29 Apr, 2022
  • 1 location
Effect of Diet Induced Ketosis on LDL Turnover Rates

have had extreme elevations of LDL that mimic familial hypercholesterolemia. These marked elevations of LDLc are unique to a ketogenic diet and far exceed the typical mild elevations seen in those

Accepts healthy volunteers
  • 17 Nov, 2021
  • 1 location
Effect of MIST on Esophageal Sensitivity in Patients With rGERD (MIST)

Effect of acute psychosocial stress on esophageal sensitivity in patients with refractory gastro-esophageal reflux disease and healthy volunteers.

  • 13 Jul, 2022
  • 1 location
  • 24 Oct, 2022
  • 80 locations