Liver Failure Clinical Trials

A listing of Liver Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 209 clinical trials
Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF

This study analyses the effect of intravenous branched chain amino acids (BCAA) on overt HE in patients with ACLF. The investigators plan to study the efficacy of combining intravenous BCAA with lactulose versus lactulose alone in the medical management of overt HE in patients with ACLF and its impact on …

amino acids
branched chain amino acids
encephalopathy
lactulose
  • 1 views
  • 23 Jan, 2021
  • 1 location
Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis

This proposal translates a hypothesis driven basic research into clinical setting to determine the potential of using autologous CD133+ cells to reverse fibrosis and improve clinical outcome for patients with end stage cirrhosis. This has significant impact on the management of cirrhosis.

cellular therapy
cd133
meld score
neupogen
fibrosis
  • 18 views
  • 02 Feb, 2021
  • 1 location
Pulmonary Rehabilitation in End-Stage Liver Disease

The purpose of this study is to assess the impact of exercise on sarcopenia and frailty. The exercise that will be performed in this study will include either pulmonary rehabilitation or a formal home based video strengthening program

liver transplant
  • 17 views
  • 26 Jan, 2021
  • 1 location
Comparison of Hypothermic Versus Normothermic Ex-vivo Preservation.

Study groups: The study is a multicenter (Pisa and Milan), prospective, randomized study comparing D-HOPE (HMP) vs NMP in DCD and ECD-DBD (extended criteria brain-dead donors). Once a DCD or a DBD with extended criteria (ECD-DBD) meets the inclusion criteria, they are randomized as follow: 20 liver grafts from DCD …

  • 0 views
  • 19 Feb, 2021
  • 2 locations
Study to Determine an Appropriate Starting Dose of Sacituzumab Govitecan-hziy in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

The primary objectives of this study are to identify the safe starting dose of sacituzumab govitecan-hziy, assess the number of participants with antibodies against sacituzumab govitecan-hziy, and evaluate the pharmacokinetics (PK) of sacituzumab govitecan-hziy, free SN-38, SN-38 glucuronide (SN-38G), total SN-38, in participants with solid tumor and moderate hepatic impairment.

absolute neutrophil count
encephalopathy
body mass index
moderate hepatic insufficiency
hepatic impairment
  • 0 views
  • 12 Sep, 2021
  • 4 locations
Mitochondrial Function in Patients With Severe Liver Disease

The researchers will recruit patients with liver disease at Parkland Hospital. Patients will fast overnight, and the next morning will receive an oral mixture of [U-13C3]glycerol (25 mg/kg) plus unlabeled glycerol (25 mg/kg). The total dose of glycerol will be 50 mg/kg in 100 milliliters of water. The taste is …

liver disease
  • 8 views
  • 08 Sep, 2021
  • 1 location
Lactoferrin in Treatment of Fe Deficient Anemia In Cirrhosis

Iron deficiency and altered homeostasis due to inflammation and decreased iron utilization are main factors involved in anemia in liver disease. Lactoferrin is a first line defence protein for protection against microbial infections and subsequent development of systemic disease as seen with systemic inflammatory response syndrome (SIRS) and sepsis. Lactoferrin …

malnutrition
haem
liver disease
chronic disease
iron supplement
  • 1 views
  • 24 Jan, 2021
  • 1 location
Use of EL-FIT App to Promote Physical Activity

Transplant-eligible patients with cirrhosis and ESLD, age 40-70, MELD >/= 10 referred to transplant physical therapy will be invited to participate. The investigators will exclude those who lack a smartphone or the understanding of its functionality, lack home wireless internet, or have recurrent/persistent overt hepatic encephalopathy. Following signing of informed …

encephalopathy
cirrhosis
  • 0 views
  • 26 Jan, 2021
  • 1 location
Rifamycin in Minimal Hepatic Encephalopathy

This is a randomized double-blind placebo-controlled trial of MHE in patients with cirrhosis using rifamycin SV-MMX 600mg BID vs placebo for 30 days with PK, safety, microbiota, brain function and brain MRI endpoints.

varices
ast/alt ratio
biopsy of liver
varicose veins
cirrhosis
  • 5 views
  • 28 Jan, 2021
  • 1 location
The Influence of Post-transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy

Through a multicenter randomized controlled trial of TIPS to prevent post-hepatitis B cirrhosis of esophagogastric varices, the incidence of hepatic encephalopathy, the rate of stent patency, the incidence of rebleeding and survival in the left and right branches of the portal vein were compared.

varices
hepatitis
endoscopy
esophageal varices
varicose veins
  • 2 views
  • 23 Jan, 2021