Liver Failure Clinical Trials

A listing of Liver Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 192 clinical trials
Deprescribing Proton Pump Inhibitors to Reduce Post-TIPS Hepatic Encephalopathy

A total of 40 patients taking proton pump inhibitors (PPIs) who undergo transjugular intrahepatic portosystemic shunt (TIPS) creation as part of routine clinical care will be randomized in 1:1 fashion to either continue or discontinue their PPIs to determine whether these commonly used gastric acid suppressing agents increase risk of …

encephalopathy
psychometric testing
portosystemic shunt
  • 0 views
  • 22 Mar, 2022
  • 1 location
Study to Assess Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis (RED-C-3131)

Study RNLC3131 is a Phase 3, randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of rifaximin SSD-40mg IR for the delay of the first episode of overt hepatic encephalopathy (OHE) decompensation in advanced liver cirrhosis, defined by the presence of medically controlled ascites.

ascites
cirrhosis
conn
liver disease
screening procedures
  • 0 views
  • 28 Apr, 2022
Safety and Clinical Activity of QEL-001 in A2-mismatch Liver Transplant Patients (LIBERATE)

The purpose of this study is to evaluate the safety and tolerability of QEL-001 in the prevention of allograft rejection following immunosuppression withdrawal in liver transplantation. QEL-001 is a product made from a liver transplant recipient's own immune cells, which are genetically modified and designed to help the transplant recipient's …

liver transplant
  • 0 views
  • 24 Mar, 2022
  • 1 location
A Study of Soticlestat in Adults With Liver Failure Compared to Those With Normal Liver Function

The main aim is to check the effect of a single dose of soticlestat in adults with moderate or severe liver failure compared to healthy adults with normal liver function. Participants

Accepts healthy volunteers
  • 0 views
  • 09 Mar, 2022
  • 3 locations
The Influence of Post-transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy

Through a multicenter randomized controlled trial of TIPS to prevent post-hepatitis B cirrhosis of esophagogastric varices, the incidence of hepatic encephalopathy, the rate of stent patency, the incidence of rebleeding and survival in the left and right branches of the portal vein were compared.

hepatitis
endoscopy
cirrhosis
esophageal varices
prothrombin
  • 2 views
  • 15 Feb, 2022
Rifamycin in Minimal Hepatic Encephalopathy

This is a randomized double-blind placebo-controlled trial of MHE in patients with cirrhosis using rifamycin SV-MMX 600mg BID vs placebo for 30 days with PK, safety, microbiota, brain function and brain MRI endpoints.

minimal hepatic encephalopathy
ast/alt ratio
brain mri
biopsy of liver
cirrhosis
  • 5 views
  • 22 Mar, 2022
  • 1 location
Normothermic Liver Preservation Trial

This trial is to assess the safety and efficacy of normothermic machine perfusion (NMP) as an organ preservation method prior to transplantation using the OrganOx metra device.

falling
liver transplant
cold
metra
organ preservation
  • 22 views
  • 24 Feb, 2022
  • 1 location
FMT in Cirrhosis and Hepatic Encephalopathy

Patients with end stage of liver disease or cirrhosis can develop confusion due to high ammonia and inflammation. This confusion is brought upon by changes in the bacteria in the bowels and may not respond to current standard of care treatments. Repeated episodes of confusion can make it difficult for …

ast/alt ratio
biopsy of liver
portal gastropathy
hypertension
varicose veins
  • 41 views
  • 05 Apr, 2022
  • 1 location
Tocotrienol Against the Progression of End Stage Liver Disease

The purpose of this Phase 2 trial is to validate the outcome observed in a previous trial that oral Tocotrienol (TCT) attenuates the rise in MELD score over time in patients with end stage liver disease / cirrhosis. The study is double blind and participants will be randomized to take …

tocotrienol
cirrhosis
nash
liver disease
fatty liver
  • 232 views
  • 21 Mar, 2022
  • 1 location
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation

To study the effects on endothelial condition and short-term outcome in different strategies of plasma transfusion during liver transplantation in patients with end-stage liver disease.

liver transplant
Accepts healthy volunteers
liver disease
cirrhosis
  • 2 views
  • 25 Feb, 2022
  • 1 location