Liver Failure Clinical Trials

A listing of Liver Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 192 clinical trials
Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;(PEGHE Trial)

Hepatic Encephaopathy is a common complication occurring in patients with Liver cirrhosis. Patients usually develop mild confusion, sleep disturbance or obtundation. It occurs due to accumulation of excess ammonia in the brain, as the liver is unable to metabolize the ammonia. The common gold standard treatment recommended for patients with …

encephalopathy
lactulose
cirrhosis
liver disease
bloating
  • 119 views
  • 18 Jul, 2021
  • 1 location
Efficacy and Safety of AXA1665 in Cirrhotic Subjects With Prior Overt Hepatic Encephalopathy (EMMPOWER)

This is a global study to compare the effects of AXA1665, an orally active mixture of amino acids, compared to placebo, on cognitive and physical function, as well as the safety and tolerability of AXA1665.

encephalopathy
screening procedures
cirrhosis
  • 0 views
  • 23 Mar, 2022
  • 21 locations
Intravenous Branched Chain Amino Acids for Hepatic Encephalopathy in ACLF (BCAA-ACLF)

This study analyses the effect of intravenous branched chain amino acids (BCAA) on overt HE in patients with ACLF. The investigators plan to study the efficacy of combining intravenous BCAA with lactulose versus lactulose alone in the medical management of overt HE in patients with ACLF and its impact on …

encephalopathy
branched chain amino acids
lactulose
amino acids
  • 7 views
  • 24 Feb, 2022
  • 1 location
TReatment for ImmUne Mediated PathopHysiology (TRIUMPH)

TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) is a multi-center, three arm, randomized, controlled trial of immunosuppressive therapy for children with acute liver failure. The study

encephalopathy
liver injury
mediators
corticosteroids
  • 0 views
  • 14 Apr, 2022
  • 4 locations
Pulmonary Rehabilitation in End-Stage Liver Disease

The purpose of this study is to assess the impact of exercise on sarcopenia and frailty. The exercise that will be performed in this study will include either pulmonary rehabilitation or a formal home based video strengthening program

liver disease
liver transplant
  • 17 views
  • 26 Feb, 2022
  • 1 location
Autologous Endothelial Progenitor Cell Therapy for Reversal of Liver Cirrhosis

This proposal translates a hypothesis driven basic research into clinical setting to determine the potential of using autologous CD133+ cells to reverse fibrosis and improve clinical outcome for patients with end stage cirrhosis. This has significant impact on the management of cirrhosis.

g-csf
neupogen
cellular therapy
cirrhosis
meld score
  • 27 views
  • 25 Feb, 2022
  • 1 location
Comparison of Hypothermic Versus Normothermic Ex-vivo Preservation. (DCDNet)

Study groups: The study is a multicenter (Pisa and Milan), prospective, randomized study comparing D-HOPE (HMP) vs NMP in DCD and ECD-DBD (extended criteria brain-dead donors). Once a DCD or a DBD with extended criteria (ECD-DBD) meets the inclusion criteria, they are randomized as follow: 20 liver grafts from DCD …

anesthesia
liver disease
  • 0 views
  • 16 Mar, 2022
  • 1 location
Study to Determine an Appropriate Starting Dose of Sacituzumab Govitecan-hziy in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

The primary objectives of this study are to identify the safe starting dose of sacituzumab govitecan-hziy, assess the number of participants with antibodies against sacituzumab govitecan-hziy, and evaluate the pharmacokinetics (PK) of sacituzumab govitecan-hziy, free SN-38, SN-38 glucuronide (SN-38G), total SN-38, in participants with solid tumor and moderate hepatic impairment.

body mass index
encephalopathy
absolute neutrophil count
moderate hepatic insufficiency
hepatic impairment
  • 0 views
  • 28 Apr, 2022
  • 6 locations
Allogenic Hepatocyte Transplantation Into Periduodenal Lymph Nodes

This Phase 2a clinical trial is a dose escalation study of the safety, tolerability, and efficacy of hepatocyte transplantation into lymph nodes via endoscopic ultrasound among subjects with end-stage liver disease who are ineligible for standard liver transplantation.

body mass index
encephalopathy
cirrhosis
hepatitis
liver disease
  • 0 views
  • 12 Mar, 2022
  • 1 location
Lactoferrin in Treatment of Fe Deficient Anemia In Cirrhosis

Iron deficiency and altered homeostasis due to inflammation and decreased iron utilization are main factors involved in anemia in liver disease. Lactoferrin is a first line defence protein for protection against microbial infections and subsequent development of systemic disease as seen with systemic inflammatory response syndrome (SIRS) and sepsis. Lactoferrin …

iron supplement
haem
malnutrition
cancer
Accepts healthy volunteers
  • 22 views
  • 03 Mar, 2022
  • 1 location