Liver Failure Clinical Trials

A listing of Liver Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 209 clinical trials
Mesenchymal Stem Cells Treatment for Decompensated Liver Cirrhosis

Decompensated liver cirrhosis is a life-threatening chronic liver disease with high mortality. Liver transplantation is the only option that can improve the survival of these patients; however, this procedure is associated with several limitations, such as the severe shortage of donor livers, long waiting lists, multiple complications, and high cost. …

  • 23 Jan, 2021
  • 1 location
Interferon and Ribavirin Treatment in Patients With Hemoglobinopathies

Worldwide, several studies report that 4.4% to 85.4% of thalassemia patients were positive for anti hepatitis C antibodies. Recently, three different studies reported the efficacy and the safety of combination therapy with pegylated interferon and ribavirin in thalassemic patients. This study is carried ahead to assess the impact of combination …

hepatitis b
  • 07 Nov, 2020
  • 1 location
The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia

Aim: To evaluate if additional cord blood transfusion could accelerate the hematopoietic reconstitution in severe aplastic anemia(SAA) patients receiving immunosuppressive therapy (IST). Study design: open-labed, prospective, multicenter, randomized control study Number of subjects: 60 each group Treatment IST group: ATG (Thymoglobuline, Genzyme) 3.5mg/kg/d5d plus oral cyclosporine A (CSA) Cord blood …

paroxysmal nocturnal hemoglobinuria
aplastic anemia
cyclosporine oral product
  • 24 Jan, 2021
  • 1 location
Adding a Second Drug for Febrile Children Treated With Acetaminophen

Fever is one of the most common symptoms in pediatrics and one of the most common reasons for visits in pediatricians' office and pediatric emergency departments. Many parents consider fever to be the most terrifying symptom. Acetaminophen and ibuprofen are both effective and safe treatments for febrile children. In order …

  • 07 Nov, 2020
  • 1 location
A Pilot Study Examining Diet in Primary Sclerosing Cholangitis

This research study is exploring the effects of dietary intervention in PSC. Study participants will be randomly assigned to either the Specific Carbohydrate Diet (SCD) or a vegan/low-sulfur diet for 8 weeks; the entire study will last approximately 14 weeks. Participants will work with BWH Registered Dieticians and receive dietary …

  • 27 Jan, 2021
  • 1 location
Apixaban for Intrahepatic Non Cirrhotic Portal Hypertension

Intrahepatic non-cirrhotic portal hypertension (INCPH) is a rare disease mostly affecting adults in their forties, characterized by portal hypertension related to alterations of intrahepatic microcirculation in the absence of cirrhosis.The only therapeutic options currently available for patients with INCPH include prophylaxis for variceal bleeding using betablockers and/or endoscopic band ligation …

  • 04 Mar, 2021
  • 1 location
The Effect of Sitagliptin on Hypertension Arterial Stiffness Oxidative Stress and Inflammation

Recently a new category of antihyperglycemic therapy aiming to modulate the incretin system has emerged. These drugs induce insulin secretion without inducing hypoglycemia. The effect of the incretin modulators drugs on hypertension, arterial stiffness, inflammation and oxidative stress parameters have not been fully investigated yet.GLP-1 analogue has been suggested to …

hemoglobin a1c
dipeptidyl peptidase-4 inhibitor
glucagon-like peptide 1
  • 07 Nov, 2020
  • 1 location
Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment

Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute deterioration in the setting of chronic liver disease associated with high short-term mortality. Currently

hepatic failure
acute on chronic liver failure
liver disease
  • 03 Feb, 2021
  • 15 locations
Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD)

This is a comparative effectiveness study of two pragmatic models aiming to introduce palliative care for end stage liver disease patients. The 2 comparators are: Model 1: Consultative Palliative Care (i.e. direct access to Palliative Care provider), Model 2: Trained Hepatologist- led PC intervention (i.e. a hepatologist will receive formal …

functional assessment
liver disease
  • 01 Feb, 2021
  • 19 locations
May the Risk of PHLF be Predicted With Preoperative Liver Gadoxetate MRI

Post hepatectomy liver failure (PHLF) is one of the most severe complications after liver re-section. Preoperative evaluation of liver function is complicated and imprecise. The volume and

  • 26 Jan, 2021
  • 7 locations