Liver Failure Clinical Trials

A listing of Liver Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 211 clinical trials
Screening for Liver Cancer With CT vs. Ultrasound in Patients With Advanced Liver Disease

The purpose of this study is to determine whether ultrasound or CT scanning is more effective at detecting early liver cancer in patients with advanced liver disease.

hepatic fibrosis
cancer
fibrosis
biopsy of liver
liver disease
  • 27 views
  • 08 Nov, 2020
  • 1 location
The Role of Bacterial Overgrowth and Delayed Intestinal Transit in Hepatic Encephalopathy

The study will be conducted in two phases. Phase A will evaluate the contribution of bacterial overgrowth and colonic inertia to development of Hepatic Encephalopathy (HE)in 50 ambulatory subjects with HE and hepatitis C cirrhosis. This phase will include a Screening and Evaluation Visit. Phase B will evaluate the effect …

cirrhosis
hepatitis
psychometric testing
rifaximin
encephalopathy
  • 118 views
  • 07 Nov, 2020
  • 1 location
Long-term Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based Treatment

Primary Objective: To evaluate the long-term outcomes including liver related morbidity, mortality and hepatocellular carcinoma (HCC) development as compared to those of historical control with interferon(IFN)-based treatment. Secondary Objective: To access liver fibrosis progression/regression in CHC patients after sofosbuvir-based treatment. To investigate the long-term outcomes of extrahepatic manifestations of the …

carcinoma
fibrosis
hepatocellular carcinoma
hepatitis
interferon
  • 40 views
  • 23 Jan, 2021
  • 18 locations
Invasive Fungal Infections in Severe Alcohol-associated Hepatitis

Chronic alcohol consumption is associated with intestinal bacterial dysbiosis, yet little is known about the role of intestinal fungi, or mycobiota in liver disease. Although the intestinal microbiome contains bacteria, fungi, and viruses, research in the field of liver disease has almost exclusively focused on the interaction between the host …

  • 1 views
  • 24 Jan, 2021
  • 1 location
Cholate Clearance in Fontans

HepQuant is an assay to measure liver function in other forms of liver disease such as hepatitis C. It measures the ability of the liver to process an naturally occurring substance called cholate and has been shown to predict clinical outcomes in some patient populations. The Fontan survivor is a …

  • 1 views
  • 17 Apr, 2021
  • 1 location
AGRA Before and After Liver Transplantation

The immune system is impaired in liver cirrhotic patients, which is associated with a high risk for bacterial infections and worse outcome. A novel biomarker, acellular growth retardation ability (AGRA), can predict the development of severe infections in patients with liver cirrhosis and therefore identify patients at risk. It is …

cirrhosis
liver transplant
  • 11 views
  • 13 Feb, 2021
  • 1 location
sCD163 in PBC Patients - Assessment of Disease Severity and Prognosis

Primary biliary cholangitis (PBC) is an autoimmune chronic liver disease, characterised by destruction of the small intrahepatic bile ducts. sCD163 is a macrophage activation marker shedded into plasma by macrophages in the liver. sMR is a soluble mannose receptor. The investigators want to investigate whether sCD163 and sMR correlate with …

cirrhosis
macrophage activation
cholangitis
liver disease
fibroscan
  • 6 views
  • 03 May, 2021
  • 1 location
The Markers and Paracetamol Poisoning Study 2

Paracetamol overdose is one of the most common medical emergencies. Annually in the UK, 100,000 people seek medical attention and 50,000 need hospital admission. Treatment is with the antidote acetylcysteine (NAC), which is effective but takes 21 hours to administer intravenously and frequently produces adverse reactions. Current tools that are …

  • 0 views
  • 10 Sep, 2021
  • 1 location
Carbon Monoxide-based Rebreathing Method and Bioimpedance in Hemodialysis Patients

The study is a case-control study with the primary aim of objectifying the volume status of patients receiving hemodialysis. Volume status will be assessed at dry weight and evaluated by a carbon monoxide rebreathing method, that measures blood volume, and bioimpedance that measures total body water. Case-control subjects will be …

  • 0 views
  • 26 Jan, 2021
  • 2 locations
sCD163 in PBC Patients - Assessment of Treatment Response

Primary biliary cholangitis (PBC) is an autoimmune chronic liver disease, characterised by destruction of the small intrahepatic bile ducts. Ursodeoxycholic acid (UDCA) is the first line treatment for patients with PBC. However, up to 40% of patients respond inadequate to this treatment. sCD163 is a macrophage activation marker shedded into …

cirrhosis
ursodiol
macrophage activation
biopsy of liver
first line treatment
  • 30 views
  • 07 May, 2021
  • 1 location