Genitourinary Cancer Clinical Trials

A listing of Genitourinary Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 183 clinical trials
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

multiple myeloma
solid tumor
alopecia
heart failure
afatinib dimaleate
  • 6097 views
  • 26 Sep, 2021
  • 1028 locations
Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors

This is a first-in-human, Phase 1, open label, multicenter, multiple dose, dose escalation and dose expansion study intended to evaluate the safety, pharmacokinetic, pharmacodynamic, and potential clinical benefit of PF-07209960, an anti-PD-1 targeting IL-15 fusion protein, in participants with selected locally advanced or metastatic solid tumors for whom no standard …

measurable disease
  • 0 views
  • 26 Sep, 2021
  • 17 locations
Maintenance With Selinexor/Placebo After Combination Chemotherapy in Participants With Endometrial Cancer [SIENDO]

This is a prospective, multicenter, double-blind, placebo-controlled, randomized Phase 3 study. The purpose of the study is to obtain evidence of efficacy for maintenance selinexor in participants with advanced or recurrent endometrial cancer. Participants with primary stage IV or recurrent disease who are in partial or complete response after having …

renal function
maintenance therapy
carcinosarcoma
recurrent disease
neutrophil count
  • 47 views
  • 26 Sep, 2021
  • 108 locations
Study of Chemoradiotherapy With or Without Pembrolizumab (MK-3475) For The Treatment of Locally Advanced Cervical Cancer (MK-3475-A18/KEYNOTE-A18/ENGOT-cx11/GOG-3047)

The purpose of this study is to evaluate the efficacy and safety of pembrolizumab plus concurrent chemoradiotherapy compared to placebo plus concurrent chemoradiotherapy in participants with locally advanced cervical cancer. The primary hypotheses are that pembrolizumab plus concurrent chemoradiotherapy is superior to placebo plus concurrent chemoradiotherapy with respect to progression-free …

adenocarcinoma
chemoradiotherapy
cancer
brachytherapy
pembrolizumab
  • 87 views
  • 23 Sep, 2021
  • 166 locations
Phase II Study of Atezolizumab + Bevacizumab in Endometrial Cancer

This is a single arm, Phase II study using the combination of atezolizumab and bevicacizumab in women with advanced, recurrent or persistent endometrial cancer. Safety and futility of this drug combination will be assessed to see what effect this treatment has on this patient population.

adenocarcinoma
bevacizumab
maintenance therapy
endometrial carcinoma
carcinosarcoma
  • 40 views
  • 20 Sep, 2021
  • 3 locations
Combination Pembrolizumab Chemotherapy and Bevacizumab in Patients With Cervical Cancer

The investigators propose to evaluate the efficacy of the combination of standard chemotherapy with bevacizumab with Pembrolizumab in women with recurrent, persistent, or metastatic cervical cancer.

anticoagulant
carboplatin
metastatic cervical cancer
carcinoma
aptt
  • 102 views
  • 23 Sep, 2021
  • 1 location
TSR-042 as Maintenance Therapy for Patients With High-risk Locally Advanced Cervical Cancer After Chemo-radiation (ATOMICC)

Patients with locally advanced cervical cancer (LACC) despite definitive chemo-radiotherapy, has a poor progression-free survival (PFS) and overall survival (OS). The hypothesis is that the use of TSR-042, checkpoint inhibitor, as consolidation therapy following concurrent chemo-radiation would increase PFS in these patients. The incorporation of immunotherapy after chemo-radiation is one …

cervical carcinoma
anticoagulant
anticoagulant therapy
carcinoma
aptt
  • 34 views
  • 16 Sep, 2021
  • 32 locations
Atezolizumab Trial in Endometrial Cancer - AtTEnd

Atezolizumab is an engineered humanised monoclonal immunoglobulin G1 antibody that binds selectively to PD-L1 and prevents its interaction with PD-1 and B7-1. In May 2016 atezolizumab was approved by the FDA for patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following any platinum-containing chemotherapy, …

carboplatin
solid tumour
carcinosarcoma
antineoplastic
carboplatin/paclitaxel
  • 499 views
  • 23 Sep, 2021
  • 132 locations
Adjuvant Sequential & Concurrent CarboTaxol + Radiotherapy for High Risk Endometrial Cancer

The purpose of this trial is to evaluate the safety of sequential and concurrent carboplatin and paclitaxel with adjuvant external beam radiotherapy for locally advanced endometrial cancer. The primary objective is to assess the acute toxicities namely grade 3-4 non hematologic and grade 4 hematologic toxicities associated with the above …

clear cell adenocarcinoma
carboplatin
serous adenocarcinoma
carcinosarcoma
paclitaxel
  • 9 views
  • 15 Sep, 2021
  • 1 location
RaPiDS- A Phase 2 Study of Anti-PD-1 Independently or in Combination With Anti-CTLA-4 in Second-Line Cervical Cancer

This is a randomized, blinded, non-comparative, two-arm Phase 2 clinical trial to assess the efficacy and safety of AGEN2034 administered with placebo (Treatment Arm 1 - monotherapy) or with AGEN1884 (Treatment Arm 2- combination therapy) for treatment of patients with advanced cervical cancer who relapsed or progressed after receiving first-line …

anticoagulant
carboplatin
platelet count
carcinoma
treatment regimen
  • 43 views
  • 26 Sep, 2021
  • 49 locations