Genitourinary Cancer Clinical Trials

A listing of Genitourinary Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 227 clinical trials
Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease

Selected patients suspected of having or with prior biopsy proof of malignant disease will be seen in the Urologic Oncology Branch, NCI. Blood samples may be collected at the time of the initial visit and at periodic intervals during the course of the disease. These samples will be stored in …

  • 21 views
  • 24 Sep, 2021
  • 1 location
Von Hippel-Lindau (VHL): Clinical Manifestations Diagnosis Management and Molecular Bases of Inherited Renal and Other Urologic Malignant Disorders

We will investigate the clinical manifestations and molecular genetic defects of heritable urologic malignant disorders. Families with urologic malignancy with known or suspected genetic basis will be enrolled. Affected individuals or individuals suspected of having a germline urologic malignant disorder will undergo periodic clinical assessment and genetic analyses for the …

clear cell renal cell carcinoma
cyst
cancer
kidney cancer
carcinoma
  • 447 views
  • 12 Sep, 2021
  • 1 location
Collection of Blood Bone Marrow Tumor or Tissue Samples From Patients With Cancer to Study Drug Resistance

This study will examine blood, bone marrow, tumor and tissue samples from patients with cancer to study tumor resistance to chemotherapy (drug treatment). Many patients with cancer improve initially with chemotherapy, but then have a disease relapse, after which their tumor no longer responds to treatment. Other patients tumors are …

cancer
recurrent disease
x-rays
treatment regimen
  • 44 views
  • 21 Sep, 2021
  • 1 location
Lymphadenectomy in Urothelial Carcinoma

Two out of three tumours in the upper urinary tract are located in the renal pelvis. Muscle-invasive urothelial carcinoma is probably more common among tumours in the upper urinary tract compared to tumours in the urinary bladder. Thus, muscle-invasive tumours represent approximately 45 % of renal pelvic tumours compared to …

  • 3 views
  • 26 Sep, 2021
  • 1 location
Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer

This study will investigate the genetic cause of Birt Hogg-Dube (BHD) syndrome and the relationship of this disorder to kidney cancer. BHD is a rare inherited condition characterized by papules, or bumps benign tumors involving hair follicles on the head and neck. People with BHD are at increased risk of …

ct scan
MRI
kidney cancer
medical photography
pneumothorax
  • 10 views
  • 12 Sep, 2021
  • 1 location
A Phase II Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma

This is a Phase II, multicenter, open-label, single arm, 2-stage study of tazemetostat 800 mg BID (twice daily) and 1600 mg QD (once daily). Subjects will be screened for eligibility within 21 days of the planned date of the first dose of tazemetostat and enrolled into one of 8 cohorts: …

cancer chemotherapy
epithelioid sarcoma
small molecule
cancer
monoclonal antibodies
  • 2 views
  • 26 Sep, 2021
  • 25 locations
Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer The PDIGREE Study

This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the …

atezolizumab
interleukin 2
ipilimumab
calcium
liver metastasis
  • 157 views
  • 26 Sep, 2021
  • 689 locations
Spanish Real-World Evidence Cabozantinib

RCC (Renal Cell Carcinoma) is the most common form of kidney cancer, accounting for 2-3% of all adult malignancies and for 90% of all kidney cancers. The incidence of RCC has steadily increased over the past two decades, showing a plateau in recent years. Many patients with RCC remain asymptomatic …

everolimus
kidney cancer
ipilimumab
angiogenesis inhibitor
vegf
  • 0 views
  • 26 Sep, 2021
  • 29 locations
Robotic-assisted vs. Open Partial Nephrectomy

ROBOCOP is an open-label, randomized controlled feasibility trial comparing robotic-assisted and open partial nephrectomy in preparation for a confirmative phase III randomized controlled trial.

nephrectomy
ct scan
kidney cancer
cancer
kidney tumor
  • 0 views
  • 20 Sep, 2021
  • 1 location
Study of ARO-HIF2 in Patients With Advanced Clear Cell Renal Cell Carcinoma

The purpose of this study is to evaluate the safety and efficacy of ARO-HIF2 injection (also referred to as ARO-HIF2) and to determine the recommended Phase 2 dose in the treatment of patients with advanced clear cell renal cell carcinoma (ccRCC).

clear cell renal cell carcinoma
carcinoma
vegf
targeted therapy
measurable disease
  • 25 views
  • 20 Sep, 2021
  • 6 locations