Chordoma Clinical Trials

A listing of Chordoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 9 clinical trials
Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

This phase I/II trial studies how well tiragolumab and atezolizumab works when given to children and adults with SMARCB1 or SMARCA4 deficient tumors that that has either come back (relapsed) or does not respond to therapy (refractory). SMARCB1 or SMARCA4 deficiency means that tumor cells are missing the SMARCB1 and …

epithelioid sarcoma
monoclonal antibodies
small molecule
measurable disease
  • 07 Apr, 2023
  • 15 locations
Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients With Recurrent Select Rare CNS Cancers

Background More than 130 primary tumors of the central nervous system (CNS) have been identified. Most affect less than 1,000 people in the United States each year. Because these tumors are so rare, there are few proven therapies. This study will test whether the immunotherapy drug nivolumab is an effective …

absolute neutrophil count
karnofsky performance status
renal function
  • 24 Oct, 2022
  • 11 locations
Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.

epithelioid sarcoma
absolute neutrophil count
karnofsky performance status
renal function
  • 04 Oct, 2022
  • 7 locations
First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGFβ Fusion Protein BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-Driven Advanced Solid Tumors

The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.

squamous cell carcinoma
chemotherapy regimen
head and neck carcinoma
  • 16 Oct, 2022
  • 9 locations
Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas (REGOSTA)

This is a randomized, double-blinded, 2 arms study concerning patients with bone sarcoma after the first line therapy. In the first arm, patients will be treated with regorafenib for a maximum of 12 months as maintenance therapy after first line therapy, whereas in the second arm, patients will be treated …

ewing's sarcoma
glomerular filtration rate
  • 04 Oct, 2022
  • 5 locations
Natural History and Biospecimen Acquisition Study for Children and Adults With Rare Solid Tumors

>Chondromyxoid fibroma Chordoma Clear cell renal carcinoma Clear Cell Sarcoma Clear cell sarcoma of kidney Conventional chordoma Dedifferentiated

cns tumor
Accepts healthy volunteers
solid tumor
  • 21 Oct, 2022
  • 4 locations
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes

essential for formation and maintenance of the notochord. Some of the other chordoma families that we studied did not have T-gene duplications; the aggregation of chordomas in these families may result from

  • 08 Apr, 2023
  • 1 location
Natural History Study of Children and Adults With Chordoma

Background Chordoma is a rare type of bone cancer. It occurs in the skull base or spine. Researchers want to study people with chordoma in different ways. They

ct scan
  • 27 Oct, 2022
  • 1 location
DMCRN-02-001: Assessing Pediatric Endpoints in DM1 (ASPIRE-DM1)

The overall goal of the study is to establish valid clinical endpoint assessments for children with congenital myotonic dystrophy type 1 and childhood myotonic dystrophy type 1, and develop biomarkers for the condition.

myotonic dystrophy
  • 07 Oct, 2022
  • 1 location