Chordoma Clinical Trials
A listing of Chordoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Found 21 clinical trials
Ion Irradiation of Sacrococcygeal Chordoma
The purpose of this study is to evaluate the safety and feasibility of primary hypofractionated irradiation of sacrococcygeal chordoma with carbon ions or protons using the raster scan technique
- 4 views
- 05 Sep, 2021
- 1 location
Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease (SACRO)
Comparative study on surgery versus definitive radiation therapy in primary localized sacral chordoma
- 71 views
- 25 Feb, 2022
- 12 locations
Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma
This is a multicenter, single arm, phase 2 study designed to evaluate the efficacy and safety of cetuximab for the treatment of advanced (unresectable)/metastatic, chordoma. The target patient
- 0 views
- 18 Jun, 2022
- 1 location
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base
This study is a prospective randomised clinical phase III trial. The primary objective of this study is to evaluate, if the innovative therapy (carbon ion irradiation) in chordomas is superior
- 47 views
- 08 Nov, 2020
A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas (REGOBONE)
INDICATION Metastatic bone sarcomas: conventional high grade osteosarcoma, Ewing sarcoma of bone, intermediate or high-grade chondrosarcomas and chordomas and
- 42 views
- 27 Apr, 2022
- 18 locations
Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant Tumors (ETOILE)
macroscopically uncompleted resected radioresistant tumors. Eligible tumors are axial chordoma (except of base of skull), adenoid cystic carcinoma of head and neck (except of trachea) and sarcomas of any site
- 23 views
- 28 Feb, 2022
- 10 locations
Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. (PalboSarc)
includes chordoma patients only (19 patients). Palbociclib will be administered orally at a dose of 125 mg once a day for 21 consecutive days followed by 7 rest days to comprise a complete cycle of
- 17 views
- 18 Jun, 2022
- 19 locations
Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors
This phase I/II trial studies how well tiragolumab and atezolizumab works when given to children and adults with SMARCB1 or SMARCA4 deficient tumors that that has either come back (relapsed) or does not respond to therapy (refractory). SMARCB1 or SMARCA4 deficiency means that tumor cells are missing the SMARCB1 and …
- 0 views
- 07 Apr, 2023
- 15 locations
TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer
. Stage 2 will enroll either chordoma patients for treatment with TAEK-VAC-HerBy alone, or HER2- positive breast and gastric/gastroesophageal junction cancer patients for combination treatment of TAEK-VAC
- 14 views
- 27 Jun, 2022
- 7 locations
Phase II Trial of the Immune Checkpoint Inhibitor Nivolumab in Patients With Recurrent Select Rare CNS Cancers
Background More than 130 primary tumors of the central nervous system (CNS) have been identified. Most affect less than 1,000 people in the United States each year. Because these tumors are so rare, there are few proven therapies. This study will test whether the immunotherapy drug nivolumab is an effective …
- 120 views
- 24 Oct, 2022
- 11 locations