Chordoma Clinical Trials

A listing of Chordoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 25 clinical trials
Ion Irradiation of Sacrococcygeal Chordoma

The purpose of this study is to evaluate the safety and feasibility of primary hypofractionated irradiation of sacrococcygeal chordoma with carbon ions or protons using the raster scan technique

  • 4 views
  • 05 Sep, 2021
  • 1 location
Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease (SACRO)

Comparative study on surgery versus definitive radiation therapy in primary localized sacral chordoma

proton therapy
antineoplastic
ct scan
  • 71 views
  • 25 Feb, 2022
  • 12 locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

>Desmoid tumors Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09/19/2018) Malignant giant cell tumors Chordoma (closed to accrual 11/29/2018)

extrahepatic cholangiocarcinoma
adenocarcinoma
immunosuppressive agents
human immunodeficiency virus
thyroiditis
  • 6637 views
  • 10 Aug, 2022
  • 752 locations
Pemetrexed for the Treatment of Chordoma

The purpose of this study is to test the safety and tolerability of pemetrexed administered to people with chordoma. Other purposes of this study are to: find out side effects

  • 0 views
  • 27 Jan, 2021
  • 1 location
CDK4/6 Inhibition in Locally Advanced/Metastatic Chordoma

In chordoma cell lines and patient biopsies, the p16 (CDKN2A) tumor suppressor is consistently deleted. Thus, chordomas are an example of a tumor with universal activation of the cyclin

palbociclib
hysterectomy
sorafenib
cancer chemotherapy
lapatinib
  • 39 views
  • 07 Jan, 2022
  • 3 locations
Nivolumab and Relatlimab in Treating Participants With Advanced Chordoma

This phase II trial studies how well nivolumab and relatlimab work in treating participants with chordoma that has spread to other places in the body. Monoclonal antibodies, such as nivolumab

neutrophil count
absolute neutrophil count
gonadotropin
human chorionic gonadotropin
cancer
  • 12 views
  • 15 May, 2022
  • 1 location
Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma

This is a multicenter, single arm, phase 2 study designed to evaluate the efficacy and safety of cetuximab for the treatment of advanced (unresectable)/metastatic, chordoma. The target patient

neutrophil count
absolute neutrophil count
measurable disease
renal function
pet/ct
  • 0 views
  • 18 Jun, 2022
  • 1 location
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base

This study is a prospective randomised clinical phase III trial. The primary objective of this study is to evaluate, if the innovative therapy (carbon ion irradiation) in chordomas is superior

proton therapy
innovative therapy
  • 47 views
  • 08 Nov, 2020
Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. (PalboSarc)

includes chordoma patients only (19 patients). Palbociclib will be administered orally at a dose of 125 mg once a day for 21 consecutive days followed by 7 rest days to comprise a complete cycle of

palbociclib
neutrophil count
absolute neutrophil count
measurable disease
liver metastasis
  • 17 views
  • 18 Jun, 2022
  • 19 locations
Talimogene Laherparepvec, Nivolumab and Trabectedin for Sarcoma (TNT)

This is a Phase 2 study using talimogene laherparepvec, nivolumab, and trabectedin as first, second or third line therapy for advanced sarcoma, including desmoid tumor and chordoma.

trabectedin
measurable disease
metastatic sarcoma
kidney function tests
platelet count
  • 37 views
  • 08 Feb, 2022
  • 1 location