Lymphoproliferative disorders Clinical Trials

A listing of Lymphoproliferative disorders medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 177 clinical trials
Haploidentical Stem Cell Transplant With Prophylactic Natural Killer DLI for Lymphoma Multiple Myeloma and CLL

This study seeks to examine the investigational use of the conditioning regimen (bendamustine, fludarabine, and rituximab) prior to haploidentical peripheral blood allogeneic stem cell transplantation with Post-Transplant Cyclophosphamide. The study will also test the investigational use of CD56-enriched Donor Lymphocyte Infusion to see if this treatment is safe, and whether …

fludarabine
low grade lymphoma
remission
t-cell lymphoma
bone marrow procedure
  • 28 views
  • 22 Sep, 2021
  • 1 location
Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

Background In allogeneic stem cell transplantation (SCT), stem cells are taken from a donor and given to a recipient. Sometimes the recipient s immune system destroys the donor s cells. Or donor immune cells attack the recipient s tissues, called graft-versus-host disease (GVHD). This is less likely when the recipient …

residual disease
fludarabine
remission
sirolimus
hematologic malignancy
  • 23 views
  • 20 Sep, 2021
  • 2 locations
A Trial of the Safety and Immunogenicity of the COVID-19 Vaccine (mRNA-1273) in Participants With Hematologic Malignancies and Various Regimens of Immunosuppression and in Participants With Solid Tumors on PD1/PDL1 Inhibitor Therapy

Background COVID-19 is a viral infection. It has spread rapidly across the globe. It has overwhelmed health systems. Researchers are concerned that it may undo years of progress in the reduction of cancer-specific death. They want to test a vaccine that might protect people with cancer from COVID-19. The COVID-19 …

bilateral oophorectomy
chronic lymphocytic leukemia
solid tumor
neutrophil count
b-cell lymphoma
  • 0 views
  • 12 Sep, 2021
  • 1 location
Venetoclax Ibrutinib Prednisone Obinutuzumab and Revlimid in Combination With Polatuzumab (ViPOR-P) in Relapsed/Refractory B-cell Lymphoma

Background Aggressive B-cell lymphomas can be cured but people with disease that resists treatment or that returns after treatment have poor outcomes with standard therapies. Indolent B-cell lymphomas are generally incurable with standard therapy and treatment is aimed at controlling symptoms and achieving a durable remissions. Researchers want to see …

flow cytometry
colony stimulating factor
gm-csf
bone marrow procedure
neutrophil count
  • 0 views
  • 12 Sep, 2021
  • 1 location
Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

This is a phase I, multi-center, open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics and clinical activity of LP-168 in subjects with relapsed or refractory B-cell malignancies. LP-168 is a small molecule inhibitor.

platelet count
neutrophil count
lymphoma
b-cell small lymphocytic lymphoma
gilbert's syndrome
  • 0 views
  • 21 Sep, 2021
  • 2 locations
Study of AZD5991 Alone or in Combination With Venetoclax in Relapsed or Refractory Haematologic Malignancies.

This study is a multicenter, open-label, nonrandomized, sequential group, dose-escalation study to assess safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of ascending doses of AZD5991 in subjects with relapsed or refractory hematologic malignancies Part 1 of the study is monotherapy dose escalation. Closed November 2020 Part 2 of the study …

richter syndrome
refractory acute myeloid leukemia (aml)
hematologic malignancy
hydroxyurea
white blood cells
  • 111 views
  • 17 Sep, 2021
  • 13 locations
PROactive Evaluation of Function to Avoid CardioToxicity

This study is intended to evaluate the ability of an intramyocardial strain analysis package with cardiac MRI to assist in the early detection and management of cardiotoxicity from therapeutics used to treat cancer.

cancer treatment
cancer
cardiac mri
strain
metastasis
  • 37 views
  • 17 Sep, 2021
  • 4 locations
Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory NHL RT MM T-PLL Acute Leukemia (AML ALL) MDS MDS/MPN and MF

This is a Phase 1, multi-center, open-label study with a dose-escalation phase (Phase 1a) and a cohort expansion phase (Phase 1b), to evaluate the safety, tolerability, and PK profile of LP-118 under a once daily oral dosing schedule in up to 100 subjects.

refractory acute myeloid leukemia (aml)
hematologic malignancy
combination chemotherapy
bone marrow procedure
hydroxyurea
  • 0 views
  • 19 Sep, 2021
  • 2 locations
Testing the Addition of an Anti-cancer Drug Hu5F9-G4 (Magrolimab) to the Usual Chemotherapy Treatment (Mogamulizumab) in T-Cell (a Type of Immune Cell) Lymphoma That Has Returned After Treatment or Does Not Respond to Treatment

This phase Ib/II trial identifies the best dose and possible benefits and/or side effects of magrolimab when given in combination with mogamulizumab in treating patients with stage IB-IV mycosis fungoides or Sezary syndrome types of T-cell lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Magrolimab …

electron beam therapy
mycosis
t-cell lymphoma
sezary syndrome
systemic therapy
  • 2 views
  • 21 Sep, 2021
  • 3 locations
A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies

This is a Phase 1/1b, multicenter, open-label, dose-escalation, and dose-expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and clinical activity of AB308 in combination with zimberelimab (AB122) in participants with advanced malignancies.

  • 0 views
  • 22 Sep, 2021
  • 18 locations