Precancerous condition Clinical Trials

A listing of Precancerous condition medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 82 clinical trials
Pembrolizumab in Treating Participants With Leukoplakia

This phase II pilot trial studies how well pembrolizumab works in treating leukoplakia. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread.

neutrophil count
monoclonal antibodies
monoclonal protein
dysplasia
thromboplastin
  • 1 views
  • 11 Jul, 2022
  • 1 location
Evaluation of the Impact of the Update SMM Criteria on the Natural History of SMM to Establish New Recommendations.

This study is a prospective open label interventional multicenter study evaluating the impact of the update multiple myeloma criteria on the natural history of smoldering myeloma in order to establish new recommendations about follow up and prognostic evaluation of smoldering myeloma.

monoclonal antibodies
monoclonal protein
multiple myeloma
bone marrow plasma cells
amyloidosis
  • 0 views
  • 04 Oct, 2022
  • 38 locations
Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System

The goal of this research is to test a distal scanning capsule and a compact redesigned version of the OFDI imaging system in healthy and BE subjects to assess ease of use, safety and feasibility in preparation for its use in a multicenter clinical trial.

volumetric laser endomicroscopy
  • 65 views
  • 31 Jul, 2021
  • 1 location
A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V

The CUV152 study will evaluate the safety of afamelanotide in XP-C and XP-V patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increases the amount of UV light needed to cause DNA damage of …

  • 0 views
  • 24 May, 2022
  • 2 locations
A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Subcutaneous Implants of Afamelanotide in Patients With Xeroderma Pigmentosum (XP)

The CUV156 study will evaluate the safety of afamelanotide in XP-C patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increases the amount of UV light needed to cause DNA damage of skin cells, …

  • 0 views
  • 14 Oct, 2022
  • 1 location
Advanced Gastrointestinal Endoscopic Imaging

To develop new methods to detect malignant and premalignant conditions of the gastrointestinal tract.

fluorescence imaging
indocyanine green
endoscopy
  • 10 views
  • 24 May, 2022
  • 1 location
High Resolution Virtual Chromoendoscopy Versus Seattle Protocol for the Surveillance of Barrett's Esophagus (CONVERSE)

The investigators hypothesize that careful examination of Barrett's esophagus by high-resolution endoscopy combined with virtual chromoendoscopy could replace the Seattle protocol for Barrett's esophagus monitoring and detection of dysplasic lesions, and thus modify existing recommendations.

endoscopy
adenocarcinoma
dysplasia
chromoendoscopy
  • 0 views
  • 07 Oct, 2022
  • 10 locations
Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection (BEEPER)

The study will compare EMR versus ESD technique (both combined with subsequent ablative therapy) of mucosal resection in Barrett's esophagus with regard to efficacy and risk in a long term setting.

endoscopic mucosal resection
endoscopic resection
barrett's esophagus
  • 8 views
  • 19 Jun, 2022
  • 2 locations
A Controlled, Randomised Multicenter Study Comparing the Effectiveness of EndoRotor (New Treatment Technique) Versus Radiofrequency (Reference Technique) in Treating Barrett's Esophagus Complicated by Dysplasia (ENDOBARRETT)

Barrett Esophagus is a common pathology, with an estimated prevalence of 1.6% at risk of progression to precancerous mucosa (low to high grade dysplasia). The incidence of adenocarcinoma on BE is 0.5% per year. In the event of dysplasia or cancer in situ, it is currently recommended at international and …

cancer
adenocarcinoma
dysplasia
probe
  • 0 views
  • 21 Oct, 2022
  • 4 locations
Sunitinib in Treating Patients With Recurrent or Unresectable Meningioma Intracranial Hemangiopericytoma or Intracranial Hemangioblastoma

RATIONALE: Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying sunitinib to see how well it works in treating patients with recurrent or unresectable meningioma, intracranial hemangiopericytoma, or intracranial hemangioblastoma.

  • 89 views
  • 07 Nov, 2020
  • 2 locations