Precancerous condition Clinical Trials

A listing of Precancerous condition medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 34 clinical trials
Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic gastroesophageal reflux disease.

intestinal metaplasia
dysplasia
adenocarcinoma
esophageal adenocarcinoma
reflux
  • 6 views
  • 22 Oct, 2022
  • 6 locations
A Multicenter Randomized Trial of Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance (The SWAT-BE Study) (SWAT-BE)

The purpose of this research study is to learn about the best approach to sample patients with known or suspected Barrett's esophagus (BE) by comparing the standard Seattle biopsy protocol to sampling using wide area transepithelial sampling (WATS3D). Barrett's esophagus is a common condition that is used to spot patients …

dysplasia
adenocarcinoma
endoscopy
cancer
esophageal adenocarcinoma
  • 0 views
  • 29 Oct, 2022
  • 1 location
Multimodal Imaging for Surveillance of Patients With Oral Potentially Malignant Disorders

This early phase I trial studies how well multimodal imaging works for surveillance in patients with oral potentially malignant disorders. New types of imaging devices may help doctors decide if a lesion in the mouth is pre-cancerous or cancerous.

multimodal imaging
proflavine hemisulfate
cancer
high-resolution microendoscopy
premalignant
  • 24 views
  • 20 Oct, 2022
  • 1 location
Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

This phase I trial tests whether metformin works in reducing the annual transformation (development of invasive cancer) of oral precancerous lesions into cancerous lesions. Metformin is a drug approved for the treatment of diabetes, but studies have shown that it may have some anticancer properties. Giving metformin may help prevent …

dysplasia
precancerous lesions
  • 0 views
  • 07 Oct, 2022
  • 1 location
Pilot, Non-randomized, Open-label Study of Intralesional Nivolumab for High Risk Oral Premalignant Lesions

To characterize the safety and tolerability of nivolumab injected intralesionally in patients with high-risk oral premalignant lesions.

  • 0 views
  • 14 Oct, 2022
  • 1 location
Evaluation of the Impact of the Update SMM Criteria on the Natural History of SMM to Establish New Recommendations.

This study is a prospective open label interventional multicenter study evaluating the impact of the update multiple myeloma criteria on the natural history of smoldering myeloma in order to establish new recommendations about follow up and prognostic evaluation of smoldering myeloma.

multiple myeloma
monoclonal antibodies
monoclonal protein
bone marrow plasma cells
amyloidosis
  • 0 views
  • 04 Oct, 2022
  • 38 locations
A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Subcutaneous Implants of Afamelanotide in Patients With Xeroderma Pigmentosum (XP)

The CUV156 study will evaluate the safety of afamelanotide in XP-C patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increases the amount of UV light needed to cause DNA damage of skin cells, …

  • 0 views
  • 14 Oct, 2022
  • 1 location
High Resolution Virtual Chromoendoscopy Versus Seattle Protocol for the Surveillance of Barrett's Esophagus (CONVERSE)

The investigators hypothesize that careful examination of Barrett's esophagus by high-resolution endoscopy combined with virtual chromoendoscopy could replace the Seattle protocol for Barrett's esophagus monitoring and detection of dysplasic lesions, and thus modify existing recommendations.

dysplasia
chromoendoscopy
adenocarcinoma
endoscopy
  • 0 views
  • 07 Oct, 2022
  • 10 locations
A Controlled, Randomised Multicenter Study Comparing the Effectiveness of EndoRotor (New Treatment Technique) Versus Radiofrequency (Reference Technique) in Treating Barrett's Esophagus Complicated by Dysplasia (ENDOBARRETT)

Barrett Esophagus is a common pathology, with an estimated prevalence of 1.6% at risk of progression to precancerous mucosa (low to high grade dysplasia). The incidence of adenocarcinoma on BE is 0.5% per year. In the event of dysplasia or cancer in situ, it is currently recommended at international and …

dysplasia
adenocarcinoma
probe
cancer
  • 0 views
  • 21 Oct, 2022
  • 4 locations
Nitrous Oxide For Endoscopic Ablation of Refractory Barrett's Esophagus (NO FEAR-BE) (NO FEAR-BE)

A multicenter, prospective, single arm, non randomized clinical trial to evaluate the safety and efficacy of the C2 CryoBalloon Focal Ablation System (CbFAS) for the treatment of persistent dysplasia or intestinal metaplasia (IM) in the tubular esophagus after 3 or more radiofrequency ablations (RFA) for dysplastic BE, or <50% eradication …

intestinal metaplasia
dysplasia
metaplasia
cryotherapy
cancer
  • 36 views
  • 21 Oct, 2022
  • 10 locations