Precancerous condition Clinical Trials

A listing of Precancerous condition medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 85 clinical trials
Immune Checkpoint Inhibitor In High Risk Oral Premalignant Lesions

This trial is designed as a prospective, multi-centre, open-label, single-arm, phase II study. Oral Premalignant Lesions (OPL) may be considered the equilibrium phase of the immunoediting

  • 8 views
  • 27 Jan, 2021
  • 5 locations
Trichloroacetic Acid as a Topical Treatment for Actinic Cheilitis

procedure of choice. TCA is a popular topical treatment for treat fine rhytides, hyperpigmentation, photodamage, and premalignant changes, such as actinic keratoses. Despite this, TCA is not commonly

  • 0 views
  • 22 Aug, 2021
  • 1 location
SUrveillance of PREMalignant Stomach - Individualized Endoscopic Follow-up (SUPREME)

Introduction: Gastric atrophy and intestinal metaplasia are the principal precursors for gastric cancer and, therefore, are considered gastric premalignant conditions. Although current

endoscopy
gastroscopy
  • 0 views
  • 21 Apr, 2022
  • 1 location
Prospective Endoscopic Follow-up of Patients With Submucosal Esophageal Adenocarcinoma (The PREFER Trial)

Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or HR T1aN0M0 EAC).

esophageal adenocarcinoma
endoscopic resection
adenocarcinoma
  • 61 views
  • 29 Jan, 2021
  • 19 locations
Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic gastroesophageal reflux disease.

intestinal metaplasia
dysplasia
endoscopy
gastroesophageal reflux
adenocarcinoma
  • 6 views
  • 22 Oct, 2022
  • 6 locations
A Multicenter Randomized Trial of Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance (The SWAT-BE Study) (SWAT-BE)

The purpose of this research study is to learn about the best approach to sample patients with known or suspected Barrett's esophagus (BE) by comparing the standard Seattle biopsy protocol to sampling using wide area transepithelial sampling (WATS3D). Barrett's esophagus is a common condition that is used to spot patients …

esophageal adenocarcinoma
cancer
endoscopy
dysplasia
abnormal cells
  • 0 views
  • 29 Oct, 2022
  • 1 location
Multimodal Imaging for Surveillance of Patients With Oral Potentially Malignant Disorders

This early phase I trial studies how well multimodal imaging works for surveillance in patients with oral potentially malignant disorders. New types of imaging devices may help doctors decide if a lesion in the mouth is pre-cancerous or cancerous.

multimodal imaging
oral cancer
high-resolution microendoscopy
proflavine hemisulfate
premalignant
  • 24 views
  • 20 Oct, 2022
  • 1 location
Multicentric Randomized Study of H. Pylori Eradication and Pepsinogen Testing for Prevention of Gastric Cancer Mortality (GISTAR)

Currently no ideal preventive modalities are available for reducing gastric-cancer caused mortality in organized population-based application. The primary objective of the study is to determine if H.pylori screening followed by eradication of positive subjects and endoscopic follow-up of those with serological evidence of atrophic gastritis reduces mortality from gastric cancer …

cancer
endoscopy
gastric cancer
Accepts healthy volunteers
gastritis
  • 21 views
  • 23 Feb, 2022
  • 1 location
Ruxolitinib for Premalignant Breast Disease (TBCRC042)

This study is evaluating how ruxolitinib affects premalignant breast cells. One half of the study participants will receive ruxolitinib for approximately 15 days, and the other half will receive

carcinoma in situ
neutrophil count
breast disease
clarithromycin
antifungals
  • 49 views
  • 23 May, 2022
  • 7 locations
Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

This phase I trial tests whether metformin works in reducing the annual transformation (development of invasive cancer) of oral precancerous lesions into cancerous lesions. Metformin is a drug approved for the treatment of diabetes, but studies have shown that it may have some anticancer properties. Giving metformin may help prevent …

dysplasia
precancerous lesions
  • 0 views
  • 07 Oct, 2022
  • 1 location