Retinoblastoma Clinical Trials

A listing of Retinoblastoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 19 clinical trials
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

recurrent intraocular retinoblastoma in at least one eye following completion of first-line therapy.

intraocular retinoblastoma
platelet count
renal function
topotecan
calcium
  • 0 views
  • 04 Oct, 2022
  • 2 locations
Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

The primary objective of this protocol is to evaluate the response rate of bilateral disease participants who have at least one eye with advanced intra-ocular retinoblastoma (stratum B) using

unilateral retinoblastoma
intraocular retinoblastoma
filgrastim
nervous
vincristine
  • 43 views
  • 07 Oct, 2022
  • 1 location
NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening Protocol

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

tazemetostat
pleural effusion
samotolisib
anti-cancer agents
cytotoxic chemotherapy
  • 1032 views
  • 25 Oct, 2022
  • 108 locations
Randomized Phase IB/II Study of Enzalutamide With and Without Ribociclib in Patients With Metastatic Castrate Resistant, Chemotherapy Naïve Prostate Cancer That Retains RB Expression

(metastatic), is chemotherapy naïve, and retains retinoblastoma expression. Testosterone can cause the growth of prostate cancer cells. Hormone therapy using enzalutamide may fight prostate cancer by blocking

bone lesion
androgen ablation
hormone therapy
androgen suppression
potassium
  • 112 views
  • 24 Oct, 2022
  • 4 locations
Safety Run-In and Phase II Trial of M7824 and Topotecan or Temozolomide in Relapsed Small Cell Cancers

damage response network. SCLC is also characterized by high DNA replication stress (RB1 inactivation, MYC and CCNE1 activation). There is only one FDA approved treatment for patients with

progressive disease
brain metastases
lung carcinoma
oat cell carcinoma
lung cancer
  • 100 views
  • 27 Oct, 2022
  • 1 location
A Phase I/II Study of Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma

Background Kaposi Sarcoma (KS) is common in people with human immunodeficiency virus (HIV) but can also occur in people who do not have HIV. KS tumors usually involve the skin, but may also involve lymph nodes, lungs, bone, and gastrointestinal tract. Researchers want to see if a drug that is …

breast cancer
systemic therapy
AIDS
progressive disease
cytotoxic chemotherapy
  • 0 views
  • 25 Oct, 2022
  • 1 location
A Phase I Study of Oral Metronomic Dosing of Oral Cyclophosphamide With Dexamethasone for Metastatic Castration Resistant Prostate Cancer

This phase I trial tests the safety and side effects of cyclophosphamide given together with dexamethasone in treating patients with castration resistant prostate cancer that has spread to other places in the body (metastatic). Chemotherapy drugs, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, …

  • 0 views
  • 28 Oct, 2022
  • 1 location
ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer

This phase II trial investigates how well ZEN-3694, enzalutamide, and pembrolizumab work in treating patients with castration-resistant prostate cancer that has spread to other places in the body (metastatic). ZEN-3694 blocks the expression of the MYC gene to prevent cellular growth in certain types of tumors, including castrate resistant prostate …

  • 0 views
  • 04 Oct, 2022
  • 2 locations
  • 0 views
  • 28 Oct, 2022
  • 8 locations
Open-label Study to Evaluate the Pharmacokinetics, Safety, and Immunogenicity of Ustekinumab in Pediatric Participants (U-POPS)

The purpose of the study is to evaluate pharmacokinetics (PK) of ustekinumab in juvenile psoriatic arthritis (jPsA) and pediatric psoriasis (PsO).

ustekinumab
rheumatism
arthritis
  • 0 views
  • 27 Oct, 2022
  • 5 locations