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Transplant Rejection Clinical Trials

A listing of Transplant Rejection medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (109) clinical trials

Precision Risk Stratification in Kidney Transplant Patients - EU-TRAIN

Allograft rejection is still a major threat to allografts with thousands of allografts failing every year worldwide due to organ rejection, with immediate consequences for the patients in terms of mortality and morbidity. With a prevalence around 20% in the first-year post transplant, rejection also carries high economic impact representing ...

Phase N/A

The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive)

The primary objective is to differentiate the clinical utility of Prospera testing from the use of creatinine testing as measured by the proportion of positive biopsies in post renal allograft patients. Secondary objectives include: To observe the performance of the Prospera assay in detecting AR (repeated validation) To evaluate whether ...

Phase N/A

PLATO - Medication Adherence in Transplant Recipients

Phase I - Control group. The standard of care will be provided to the control group pre- and post-transplant. This does not involve any direct pre-transplant assessment of medication adherence or risk factors for non-adherence. Tacrolimus capsules (standard of care immunosupression medication) will be dispensed in Medication Event Monitoring System ...

Phase N/A

Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister Donor

In spite of the pronounced benefit of kidney transplantation in prolonging survival and improving the quality of life of patients with end stage renal disease, it is still hampered by the risk of graft rejection and the need for lifelong immunosuppression. Researchers have sought to circumvent these challenges through the ...


Using the Speckle Doppler to Quantify Blood Flow in Kidney and Pancreas Grafts

BACKGROUND After reperfusion in solid organ transplantation, the quality of organ reperfusion is often assessed visually and reported as good, moderate, reasonable, patchy or poor. In our centre a Renogram is usually performed which uses radioactive tracer which most kidney transplant recipients would have within 24 hours after transplantation to ...

Phase N/A

Immunosuppressive Drugs and Gut Microbiome: Pharmacokinetic- and Microbiome Diversity Effects

The analyses of feces samples will be performed by utilizing shotgun, next generation sequencing in order to determine the bacterial, fungal sand viral microbiome. Drug concentrations will be analyzed with high performance Liquid chromatography With double mass spectrometry detector (HPLC-MS/MS) technology and both free and total plasma MPA concentrations, total ...


Subclass of Donor-specific Antibody as a Risk Factor of Antibody Mediated Rejection in Renal Transplantation

Antibody-mediated rejection is now recognized as the first cause of long-term kidney transplant loss. This type of rejection is mediated by the presence of graft-specific antibodies, usually directed against HLA (Human Leukocyte Antigens), called DSA (Donor Specific Antibody). It results from the interaction between DSA and HLA present on the ...

Phase N/A

Clinical Trials in Organ Transplantation Extension Study

There are no mandated study visits, rather the study will be conducted using real world data collected as part of usual clinical care according to the standard of care transplant protocols at each site. Specimens and study data will be collected during standard of care visits and study coordinators will ...

Phase N/A

RCT Comparing Immunosuppressive Regimens in Elderly Renal Transplant Recipients

In this study two immunosuppressive regimes will be tested; In both groups basiliximab induction will be applied. Additionally, the standard therapy consisting of prednisolone, mycophenolic acid and tacrolimus once-daily (Envarsus), or the comparator in which mycophenolic acid will be replaced by everolimus combined with strongly reduced levels of tacrolimus once-daily ...