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Acute Pain Clinical Trials

A listing of Acute Pain medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found (81) clinical trials

Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)

TKA is the standard of care for treating patients suffering from end-stage knee arthritis and other disabling knee injuries. Indications have increased to ever younger patients and, combined with the aging US population, nearly 700,000 Americans receive TKAs each year. In spite of surgery, many patients experience persistent pain, stiffness …

Phase

Clinical Utility of Pharmacogenomics of Psychotropic Medications

There is considerable inter-individual variability in therapeutic drug response, required dosage and adverse effects in psychotropic treatment. Few patients experience a remission of their illness when initially treated with any medications.1,2 In those who remain symptomatic, less than half will experience a significant improvement with a change in medication or …

Phase

Comparison of the Effectiveness of Preemptive Paracetamol and Ibuprofen in Acute Postoperative Pain

Laparoscopic cholecystectomy is a type of surgery that causes moderate postoperative pain. Paracetamol and non-steroid anti-inflammatory analgesics plus opioids are the mainstay treatment options of the moderate postoperative pain. These drugs are the most common used analgesics to ameliorate this type of pain and to reduce the consumption of opioids …

Phase

Dosing of Ketorolac in the Emergency Department

Patients from 4 groups will be treated with 3 different doses of ketorolac. The groups are 1. headache 2. abdominal pain 3. musculo-skeletal pain 4. viral syndrome. The doses will be 0, 10, 30mgs of ketorolac to clarify the placebo effect and the optimal dosage as a function of condition.

Phase

Do Cervical Interlaminar Epidural Steroid Injections With Low-dose Lidocaine Cause Transient Objective Upper Extremity Weakness? A Prospective Randomized Controlled Trial

Control Group: Prospective observational cohort study of UE strength in pain clinic patients undergoing trigger point injections and occipital nerve injections to serve as controls to measure variability of strength testing before and 30 min after such an intervention. Experimental Groups: Prospective, randomized, controlled, double blinded trial in patients undergoing …

Phase

Utility of Pharmacogenomic Testing and Postoperative Dental Pain Outcomes

To date, the use of pharmacogenomic methods in medicine has broadened our understanding of the important role of genes and different phenotypes/genotypes that make each individual unique in pain responses, including drug biotransformation, transportation, and drug-related side effects to name a few.Thus, recognizing the genetic profile of each individual prior …

Phase

EXPAREL for Minimally Invasive Supracervical Hysterectomies

Exparel is a local analgesic that utilizes bupivacaine in combination with the proven product delivery platform, DepoFoam. Exparel (bupivacaine liposome injectable suspension) is a liposome injection of bupivacaine, an amide-type local anesthetic, indicated (bupivacaine liposome injectable suspension) for administration into the surgical site to produce postsurgical analgesia. Liposomal drug- containing …

Phase

Evaluate The Pharmacokinetics and Safety Of Oxycodone Oral Solution In Pediatric and Adolescent Subjects

This is a Phase IV study to characterize the pharmacokinetics and to evaluate the safety of Oxycodone Oral Solution administered to pediatric and adolescent subjects for postoperative pain. It is an open label, multicenter study conducted at up to 10 sites. Subjects will be enrolled preoperatively up to 14 days …

Phase

Intra-operative Lidocaine Infusion in Preventing CPSP Post VATs

It is not surprising that complications related to surgical procedures occur. Chronic Post Surgical Pain (CPSP) is considered one of the more common surgical complications, despite all the advances in understanding acute pain and the development of new modalities for pain management 1. Chronic Post Surgical Pain was defined by …

Phase

Randomized Double-blind Placebo Controlled Cross Over Design Topical Morphine for Analgesia in Pediatric Procedures

The use of an opioid such as morphine topical gel 30 minutes before a procedure would be effective in reducing pain in children. It has proven effective analgesic with minimal adverse effects, especially in children older than 6 months, and even its use is authorized in young children.

Phase