Hematologic Neoplasms Clinical Trials

A listing of Hematologic Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 63 clinical trials
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced Metastatic or Unresectable Cancer

This phase Ib trial studies the side effects of nivolumab and to see how well it works in treating patients with autoimmune disorders and cancer that has spread to other places in the body or cannot removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's …

metastasis
autoimmune disease
tumor cells
carcinoma
glomerular filtration rate
  • 620 views
  • 26 Sep, 2021
  • 30 locations
Study of AZD5991 Alone or in Combination With Venetoclax in Relapsed or Refractory Haematologic Malignancies.

doses of AZD5991 in subjects with relapsed or refractory hematologic malignancies Part 1 of the study is monotherapy dose escalation. Closed November 2020 Part 2 of the study is monotherapy expansion

daratumumab
richter syndrome
gilbert's syndrome
multiple myeloma
lymphocytic leukemia
  • 111 views
  • 17 Sep, 2021
  • 13 locations
Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphoma or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back (recurrent) or do not respond to treatment (refractory) and have spread to other places in the body (advanced). …

metastasis
cns metastases
match treatment
colony stimulating factor
tumor cells
  • 68 views
  • 26 Sep, 2021
  • 78 locations
Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

Background Lymphoma is a type of blood cancer. Blood cell transplant can cure some people with lymphoma. Researchers want to see if they can limit the

chemotherapy regimen
anaplastic large cell lymphoma
urine tests
therapeutic agents
colony stimulating factor
  • 3 views
  • 26 Sep, 2021
  • 2 locations
Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

Background In allogeneic stem cell transplantation (SCT), stem cells are taken from a donor and given to a recipient. Sometimes the recipient s immune system destroys the donor s cells. Or donor immune cells attack the recipient s tissues, called graft-versus-host disease (GVHD). This is less likely when the recipient …

chemotherapy regimen
bone lesion
induction chemotherapy
therapeutic agents
acute leukemia
  • 23 views
  • 28 Sep, 2021
  • 2 locations
Haplo-identical Transplantation for Severe Aplastic Anemia Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis

Background Severe aplastic anemia (SAA), and myelodysplastic syndrome (MDS), and paroxysmal nocturnal hemoglobinuria (PNH) cause serious blood problems. Stem cell transplants using bone marrow or blood plus chemotherapy can help. Researchers want to see if using peripheral blood stem cells (PBSCs) rather than bone marrow cells works too. PBSCs are …

  • 16 views
  • 26 Sep, 2021
  • 1 location
Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

Background Less toxic and more effective treatments are needed for cancers caused by viruses. These cancers include Hodgkin and non-Hodgkin lymphoma, hepatocellular carcinoma, head and neck cancer, nasopharyngeal carcinoma, gastric cancer, anal cancer, cervical cancer, vaginal cancer, vulvar cancer, penile cancer, Merkel cell carcinoma, Kaposi sarcoma, and leiomyosarcoma. Researchers want …

vincristine
tumor cells
carcinoma
antiretroviral therapy
lymphoma
  • 0 views
  • 27 Sep, 2021
  • 1 location
Resveratrol and Cardiovascular Health in the Elderly

Background Resveratrol is a compound found in the skin of red grapes. It is being tested to see if it can have positive effects on human health. Lab studies show that it may help lower blood sugar, improve heart and blood vessel health, and prevent cancer. Researchers want to test …

cancer
stress test
  • 291 views
  • 24 Sep, 2021
  • 1 location
Molecular Imaging of Primary Amyloid Cardiomyopathy

Cardiac amyloidosis is a major cause of early treatment-related death and poor overall survival in individuals with systemic light chain amyloidosis. This project will develop a novel approach to visualize cardiac amyloid deposits using advanced imaging methods. The long-term goal of this work is to identify the mechanisms of cardiac …

natriuretic peptide
amyloid deposits
c-11 acetate
multiple myeloma
nesiritide
  • 28 views
  • 27 Sep, 2021
  • 1 location
Trial of EP0057 a Nanoparticle Camptothecin With Olaparib in People With Relapsed/Refractory Small Cell Lung Cancer

Background: EP0057 consists of a sugar molecule cyclodextrin linked to a chemotherapy drug called camptothecin. The combined molecule or "nanoparticle drug conjugate" travels through the blood. Once inside cancer cells, the chemotherapy drug is released from the molecule. Olaparib is a drug that may stop cancer cells from repairing the …

testosterone
metastasis
olaparib
tubal ligation
diphosphonates
  • 192 views
  • 27 Sep, 2021
  • 1 location