Huntington's Disease Clinical Trials

A listing of Huntington's Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found 45 clinical trials
A Dose Range Finding Study With Open-Label Extension to Evaluate the Safety of Oral LMI070/Branaplam in Early Manifest Huntington's Disease (VIBRANT-HD)

This is the first study of branaplam in adults with Huntington's Disease (HD) to determine the correct dose required to lower mutant huntingtin protein (mHTT) levels in the cerebrospinal fluid

  • 2 views
  • 24 Jul, 2022
  • 20 locations
  • 0 views
  • 27 Apr, 2022
  • 30 locations
Clinical Applications of (S)-[18F]FBFP PET/CT in Healthy Volunteers and Patients With Central Nervous System Diseases

This is an open-label whole-body PET/CT (positron emission tomography/computed tomography) study for investigation of radiation dosimetry, plasma pharmacokinetics, biodistribution, safety and diagnostic performance of (S)-[18F]FBFP in healthy volunteers and patients with central nervous system diseases. A single dose of nearly 370 MBq (S)-[18F]FBFP will be intravenously injected into healthy volunteers …

Accepts healthy volunteers
  • 0 views
  • 30 Apr, 2022
  • 1 location
Study of WVE-003 in Patients With Huntington's Disease

This is a Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and PD of WVE-003 in adult patients with early-manifest HD who carry the targeted single nucleotide polymorphism (SNP) - SNP3.

  • 1 views
  • 26 Jul, 2022
  • 22 locations
OCTA in Mild Cognitive Impairment and Alzheimer's Disease

persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD) or other neurodegenerative disease, multiple sclerosis, and Huntington's disease.

multiple sclerosis
cognitive impairment
mild cognitive impairment
disease or disorder
huntington's disease
  • 31 views
  • 25 Jan, 2022
  • 1 location
Safety and Efficacy of AMT-130 in European Adults With Early Manifest Huntington Disease

This is the second study of AMT-130 in patients with early manifest HD and is designed as part of an integrated two-study phase I/II program under a single data safety monitoring board (DSMB) with staggered enrollment based upon continued demonstration of safety of AMT-130 administration.

htt gene
  • 0 views
  • 21 Mar, 2022
  • 1 location
Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease

Examine the effects of deutetrabenazine on functional speech and gait impairment

cognitive assessment
  • 1 views
  • 24 Jan, 2022
  • 1 location
Symptomatic Therapy for Patients With Huntington's Disease

Based on the previous symptomatic treatment of Chinese HD patients, this study intends to further optimize the treatment regimen of Chinese HD patients so as to further improve the prognosis of patients.

treatment regimen
risperidone
  • 0 views
  • 24 Jan, 2022
  • 1 location
Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington Disease

This is the first study of AMT-130 in patients with early manifest HD and is designed to establish safety and proof-of-concept (PoC). CT-AMT-130-01 is a Phase I/II, randomized, multicenter, dose escalation, double-blind, imitation surgery, first-in-human (FIH) study.

htt gene
chorea
  • 161 views
  • 17 Feb, 2022
  • 12 locations
Risperidone for the Treatment of Huntington's Disease Involuntary Movements

The purpose of this study is to assess the safety and benefit of risperidone for the treatment of chorea (involuntary movements) in Huntington's disease. Risperidone is commonly used in clinical

chorea
involuntary movements
risperidone
  • 105 views
  • 24 Jan, 2022
  • 1 location